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Título:
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Daphnanes diterpenes from the latex of Hura crepitans L. And activity against human colorectal cancer cells Caco-2
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Autores:
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Trinel, M. ;
Le Lamer, A.-C. ;
Jullian, V. ;
Jacquemin, D. ;
Graton, J. ;
Cristofoli, V. ;
Crossay, E. ;
Yassine, M. ;
Rolland, C. ;
Vergnolle, N. ;
Mejia, K. ;
Joel Cabanillas, B. ;
Racaud-Sultan, C. ;
Fabre, N.
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Tipo de documento:
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texto impreso
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Editorial:
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Academic Press Inc., 2020-12-14T16:10:20Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Hura crepitans (Euphorbiaceae) is a tree from South America that produces an irritant latex used as a fish poison. A bio-guided fractionation of an ethanolic extract of the latex led to the isolation and structural identification of three known daphnane-type diterpenes (1–3) including huratoxin (1), together with two new analogs (4, 5). Compound 1 was found to exhibit significant and selective cell growth inhibition against the colorectal cancer cell line Caco-2, with morphological modifications suggesting formations mimicking the intestinal crypt architecture. The underlying mechanism of 1 was further investigated, in comparison with 12-O-tetradecanoylphorbol-13-acetate (TPA), revealing two different mechanisms. © 2020 Elsevier Inc.
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/8831
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