|
Título:
|
Building capacity for advances in tuberculosis research; proceedings of the third RePORT international meeting
|
|
Autores:
|
Van der Heijden, Yuri F. ;
Abdullah, Fareed ;
Andrade, Bruno B. ;
Andrews, Jason R. ;
Christopher, Devasahayam J. ;
Croda, Julio ;
Ewing, Heather ;
Haas, David W. ;
Hatherill, Mark ;
Horsburgh, C. Robert ;
Mave, Vidya ;
Nakaya, Helder I. ;
Rolla, Valeria ;
Srinivasan, Sudha ;
Sugiyono, Retna Indah ;
Ugarte-Gil, Cesar ;
Hamilton, Carol
|
|
Tipo de documento:
|
texto impreso
|
|
Editorial:
|
Elsevier, 2018-11-08T19:39:22Z
|
|
Nota general:
|
info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
|
|
Idiomas:
|
Inglés
|
|
Palabras clave:
|
Editados por otras instituciones
,
Artículos
,
Artículos en revistas indizadas
|
|
Resumen:
|
RePORT International is a global network of research sites in India, Brazil, Indonesia, South Africa, China, and the Philippines dedicated to collaborative tuberculosis research in the context of HIV. A standardized research protocol (the Common Protocol) guides the enrollment of participants with active pulmonary tuberculosis and contacts into observational cohorts. The establishment of harmonized clinical data and bio-repositories will allow cutting-edge, large-scale advances in the understanding of tuberculosis, including identiï¬ cation of novel biomarkers for progression to active tuberculosis and relapse after treatment. The RePORT International infrastructure aims to support research capacity development through enabling globally-diverse collaborations. To that end, representatives from the RePORT International network sites, funding agencies, and other stakeholders gathered together in Brazil in September 2017 to present updates on relevant research ï¬ ndings and discuss ideas for collaboration. Presenters emphasized research involving biomarker identiï¬ cation for incipient tuberculosis, host immunity and pharmacogenomics, co-morbidities such as HIV and type 2 diabetes mellitus, and tuberculosis transmission in vulnerable and high-risk populations. Currently, 962 active TB participants and 670 household contacts have contributed blood, sputum, urine and microbes to in-country biorepositories. Crossconsortium collaborations have begun sharing data and specimens to analyze molecular and cytokine predictive patterns.
|
|
En línea:
|
http://doi.org/10.1016/j.tube.2018.09.009
|
