|
Título:
|
Regional differences of leptospirosis in Sri Lanka: observations from a flood-associated outbreak in 2011
|
|
Autores:
|
Agampodi, Suneth B. ;
Dahanayaka, Niroshan J. ;
Bandaranayaka, Anoma K. ;
Perera, Manoj ;
Priyankara, Sumudu ;
Weerawansa, Prasanna ;
Matthias, Michael A. ;
Vinetz, Joseph M.
|
|
Tipo de documento:
|
texto impreso
|
|
Editorial:
|
Public Library of Science, 2020-06-10T18:12:16Z
|
|
Nota general:
|
info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
|
|
Idiomas:
|
Inglés
|
|
Palabras clave:
|
Editados por otras instituciones
,
Artículos
,
Artículos en revistas indizadas
|
|
Resumen:
|
Leptospirosis is known to be an important cause of weather disaster-related infectious disease epidemics. In 2011, an outbreak of leptospirosis occurred in the relatively dry district of Anuradhapura, Sri Lanka where diagnosis was resisted by local practitioners because leptospirosis was not known in the area and the clinical presentation was considered atypical. To identify the causative Leptospira associated with this outbreak, we carried out a cross-sectional study. Consecutive clinically suspected cases in this district were studied during a two-and-a-half-month period. Of 96 clinically suspected cases, 32 (33.3%) were confirmed by qPCR, of which the etiological cause in 26 cases was identified using 16S rDNA sequencing to the species level. Median bacterial load was 4.1 x 10(2)/mL (inter-quartile range 3.1-6.1 x 10(2)/mL). In contrast to a 2008 Sri Lankan leptospirosis outbreak in the districts of Kegalle, Kandy, and Matale, in which a predominance of Leptospira interrogans serovars Lai and Geyaweera was found, most cases in the 2011 outbreak were caused by Leptospira kirschneri. Seven (21.9%) confirmed cases had acute renal failure; five (15.6%) had myocarditis; severe thrombocytopenia (
|
|
En línea:
|
http://doi.org/10.1371/journal.pntd.0002626
|
