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In the last few years, genetic and functional studies have provided important insight on the pathophysiology of excessive erythrocytosis (EE), the main sign of Chronic Mountain Sickness (CMS). The recent finding of the association of the CMS phe[...]texto impreso
Tushaus, Laura ; Moreo, Monica ; Zhang, Jia ; Hartinger, Stella Maria ; Mäusezahl, Daniel ; Karlen, Walter | American Physiological Society | 2019-12-06T21:02:56ZMeasuring peripheral oxygen saturation (SpO2) with pulse oximeters at the point of care is widely established. However, since SpO2 is dependent on ambient atmospheric pressure, the distribution of SpO2 values in populations living above 2000 m a[...]texto impreso
Villafuerte, Francisco-C. ; Corante, Noemi ; Anza-Ramirez, Cecilia ; Figueroa-Mujíca, Rómulo ; Vizcardo-Galindo, Gustavo ; Mercado, Andy ; Macarlupu, Jose-Luis ; Leon-Velarde, Fabiola | American Physiological Society | 2019-02-06T14:48:07ZExcessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a highly prevalent syndrome in Andean highlanders. Low pulse O2 saturation (SpO2) during sleep and serum androgens have been suggested to contribute to EE in CMS [...]texto impreso
Gassmann, Norina-N. ; van-Elteren, Hugo-A. ; Goos, Tom-G. ; Morales, Claudia-R. ; Rivera-Ch, Maria ; Martin, Daniel-S. ; Cabala-Peralta, Patricia ; Passano-Del-Carpio, Agustin ; Aranibar-Machaca, Saul ; Huicho, Luis ; Reiss, Irwin-K. M. ; Gassmann, Max ; de-Jonge, Rogier-C. J. | American Physiological Society | 2019-02-06T14:45:34ZThe developing human fetus is able to cope with the physiological reduction in oxygen supply occurring in utero. However, it is not known if microvascularization of the fetus is augmented when pregnancy occurs at high altitude. Fifty-three healt[...]texto impreso
Surfactant dysfunction during over-expression of TGF-?1 precedes profibrotic lung remodeling in vivo
López Rodríguez, Elena ; Boden, Caroline ; Echaide Torreguitar, Mercedes ; Pérez Gil, Jesús ; Kolb, Martin ; Gauldie, Jack ; Maus, Ulrich A. ; Ochs, Matthias ; Knudsen, Lars | American Physiological Society | 2016-06Surfactant dysfunction during overexpression of TGF-1 precedes profibrotic lung remodeling in vivo. Am J Physiol Lung Cell Mol Physiol 310: L1260 –L1271, 2016. First published April 22, 2016; doi:10.1152/ajplung.00065.2016.— Transforming growth [...]texto impreso
De Luca, Daniele ; Shankar-Aguilera, Shivani ; Autilio, Chiara ; Raschetti, Roberto ; Vedovelli, Luca ; Fitting, Catherine ; Payré, Christine ; Jeammet, Louise ; Pérez Gil, Jesús ; Cogo, Paola E. ; Carnielli, Virgilio P. ; Lambeau, Gérard ; Touqui, Lhoussaine | American Physiological Society | 2020-06-25Secreted phospholipase A2 hydrolyzes surfactant phospholipids and is crucial for the inflammatory cascade; preterm neonates are treated with exogenous surfactant, but the interaction between surfactant and phospholipase is unknown. We hypothesiz[...]