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Título:
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Global REACH 2018: renal oxygen delivery is maintained during early acclimatization to 4,330 m
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Autores:
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Steele, A.R. ;
Tymko, M.M. ;
Meah, V.L. ;
Simpson, L.L. ;
Gasho, C. ;
Dawkins, T.G. ;
Villafuerte, F.C. ;
Ainslie, P.N. ;
Stembridge, M. ;
Moore, J.P. ;
Steinback, C.D.
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Tipo de documento:
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texto impreso
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Editorial:
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NLM (Medline), 2020-12-14T16:10:15Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Early acclimatization to high altitude is characterized by various respiratory, hematological, and cardiovascular adaptations that serve to restore oxygen delivery to tissue. However, less is understood about renal function and the role of renal oxygen delivery (RDO2) during high altitude acclimatization. We hypothesized that 1) RDO2 would be reduced after 12 h of high altitude exposure (high altitude day 1) but restored to sea level values after 1 wk (high altitude day 7) and 2) RDO2 would be associated with renal reactivity, an index of acid-base compensation at high altitude. Twenty-four healthy lowlander participants were tested at sea level (344 m, Kelowna, BC, Canada) and on day 1 and day 7 at high altitude (4,330 m, Cerro de Pasco, Peru). Cardiac output, renal blood flow, and arterial and venous blood sampling for renin-angiotensin-aldosterone system hormones and NH2-terminal pro-B-type natriuretic peptides were collected at each time point. Renal reactivity was calculated as follows: (?arterial bicarbonate)/(?arterial Pco2) between sea level and high altitude day 1 and sea level and high altitude day 7. The main findings were that 1) RDO2 was initially decreased at high altitude compared with sea level (?RDO2: -22 ±?17%, P
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/8816
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