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Título:
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Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis
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Autores:
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Sathyamoorthy, T. ;
Sandhu, G. ;
Tezera, L.B. ;
Thomas, R. ;
Singhania, A. ;
Woelk, C.H. ;
Dimitrov, B.D. ;
Agranoff, D. ;
Evans, C.A.W. ;
Friedland, J.S. ;
Elkington, P.T.
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Tipo de documento:
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texto impreso
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Editorial:
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Public Library of Science, 2019-04-24T18:23:57Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively studied in plasma, nor have gender differences been investigated. We measured the plasma concentrations of MMPs in a carefully characterised, prospectively recruited clinical cohort of 380 individuals. The collagenases, MMP-1 and MMP-8, were elevated in plasma of patients with pulmonary TB relative to healthy controls, and MMP-7 (matrilysin) and MMP-9 (gelatinase B) were also increased. MMP-8 was TB-specific (p
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En línea:
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http://doi.org/10.1371/journal.pone.0117605
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