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Título:
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Regulatory t-cell dynamics in cutaneous and mucocutaneous leishmaniasis due to leishmania braziliensis
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Autores:
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Barros, Nicolas ;
Vasquez, Nestor ;
Woll, Fernando ;
Sanchez, Cesar ;
Valencia, B. M. ;
Llanos-Cuentas, Alejandro ;
White, A. Clinton ;
Montes, Martin
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Tipo de documento:
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texto impreso
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Editorial:
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American Society of Tropical Medicine and Hygiene, 2018-12-01T00:04:15Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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To evaluate the dynamics of regulatory T cells (Tregs) during tegumentary leishmaniasis, we assessed peripheral blood and biopsies from 54 patients. Patients with cutaneous leishmaniasis (CL) had a decreased proportion of Tregs in the peripheral blood, but the proportion was higher in the biopsies of lesions. During treatment of CL, circulating Tregs increased reaching normal proportions, whereas antigen-specific interferon-? responses diminished. By contrast, circulating Tregs from mucosal leishmaniasis patients failed to normalize during treatment. C-C chemokine receptor type 5 was expressed on a large proportion of Tregs at the site of infection. These results demonstrate increased Tregs at the site of infection, possibly homing from the peripheral circulation.
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En línea:
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http://doi.org/10.4269/ajtmh.17-0624
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