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Título:
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Cardiometabolic correlates of sleep disordered breathing in Andean highlanders
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Autores:
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Pham, Luu V. ;
Miele, Catherine H. ;
Schwartz, Noah G. ;
Arias, Rafael S. ;
Rattner, Adi ;
Gilman, Robert H. ;
Miranda, J. Jaime ;
Polotsky, Vsevolod Y. ;
Checkley, William ;
Schwartz, Alan R.
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Tipo de documento:
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texto impreso
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Editorial:
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European Respiratory Society, 2019-01-25T15:02:19Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Associations between sleep disordered breathing (SDB) and cardiometabolic outcomes have not been examined in highlanders.We performed nocturnal polygraphy in Peruvian highlanders (3825 m). Multivariable linear regression models examined associations between SDB metrics and haemoglobin, glucose tolerance (haemoglobin A1c (HbA1c)), fasting glucose, homeostatic model-based assessments of insulin resistance and beta-cell function (HOMA-IR and HOMA-beta, respectively), blood pressure, and lipids, while adjusting for age, sex, body mass index (BMI) and wake oxygenation.Participants (n=187; 91 men) were (median (interquartile range)) 52 (45-62) years old, and had a BMI of 27.0 (24.3-29.5) kg.m(-2) and 87% (85-88%) oxyhaemoglobin (arterial oxygen) saturation during wakefulness. In fully adjusted models, worsening nocturnal hypoxaemia was associated with haemoglobin elevations in men (p=0.03), independent of wake oxygenation and apnoea-hypopnoea index (AHI), whereas worsening wake oxygenation was associated with haemoglobin elevations in older women (p=0.02). In contrast, AHI was independently associated with HbA1c elevations (p
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En línea:
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http://doi.org/10.1183/13993003.01705-2016
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