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Título:
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Effect of salt substitution on community-wide blood pressure and hypertension incidence
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Autores:
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Bernabé-Ortiz, Antonio ;
Sal Y Rosas, Víctor G. ;
Ponce-Lucero, Vilarmina ;
Cárdenas, María K. ;
Carrillo-Larco, Rodrigo M. ;
Diez-Canseco, Francisco ;
Pesantes, M. Amalia ;
Sacksteder, Katherine A. ;
Gilman, Robert H. ;
Miranda, J. Jaime
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Tipo de documento:
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texto impreso
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Editorial:
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Nature Research, 2020-07-14T00:00:57Z
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Nota general:
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info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Replacement of regular salt with potassium-enriched substitutes reduces blood pressure in controlled situations, mainly among people with hypertension. We report on a population-wide implementation of this strategy in a stepped-wedge cluster randomized trial (NCT01960972). The regular salt in enrolled households was retrieved and replaced, free of charge, with a combination of 75% NaCl and 25% KCl. A total of 2,376 participants were enrolled in 6 villages in Tumbes, Peru. The fully adjusted intention-to-treat analysis showed an average reduction of 1.29?mm Hg (95% confidence interval (95% CI) (-2.17, -0.41)) in systolic and 0.76?mm?Hg (95% CI (-1.39, -0.13)) in diastolic blood pressure. Among participants without hypertension at baseline, in the time- and cluster-adjusted model, the use of the salt substitute was associated with a 51% (95% CI (29%, 66%)) reduced risk of developing hypertension compared with the control group. In 24-h urine samples, there was no evidence of differences in sodium levels (mean difference 0.01; 95% CI (0.25, -0.23)), but potassium levels were higher at the end of the study than at baseline (mean difference 0.63; 95% CI (0.78, 0.47)). Our results support a case for implementing a pragmatic, population-wide, salt-substitution strategy for reducing blood pressure and hypertension incidence.
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/8234
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