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Título:
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Imaging mass spectrometry assists in the classification of diagnostically challenging atypical Spitzoid neoplasms
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Autores:
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Lazova, Rossitza ;
Seeley, Erin-H. ;
Kutzner, Heinz ;
Scolyer, Richard-A. ;
Scott, Glynis ;
Cerroni, Lorenzo ;
Fried, Isabella ;
Kozovska, Milena-E. ;
Rosenberg, Arlene-S. ;
Prieto, Victor-G. ;
Shehata, Bahig-M. ;
Durham, Megan-M. ;
Henry, Gina ;
Rodriguez-Peralto, Jose-L. ;
Riveiro-Falkenbach, Erica ;
Schaefer, Jochen-T. ;
Danialan, Richard ;
Fraitag, Sylvie ;
Vollenweider-Roten, Sonja ;
Sepehr, Alireza ;
Sangueza, Martin ;
Hijazi, Nouf ;
Corredoira, Yamile ;
Kowal, Rachel ;
Harris, Olga-M. ;
Bravo, Francisco ;
Boyd, Alan-S. ;
Gueorguieva, Ralitza ;
Caprioli, Richard-M.
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Tipo de documento:
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texto impreso
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Editorial:
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Elsevier, 2019-02-06T14:45:36Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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BACKGROUND: Previously, using imaging mass spectrometry (IMS), we discovered proteomic differences between Spitz nevi and Spitzoid melanomas. OBJECTIVE: We sought to determine whether IMS can assist in the classification of diagnostically challenging atypical Spitzoid neoplasms (ASN), to compare and correlate the IMS and histopathological diagnoses with clinical behavior. METHODS: We conducted a retrospective collaborative study involving centers from 11 countries and 11 US institutions analyzing 102 ASNs by IMS. Patients were divided into clinical groups 1 to 4 representing best to worst clinical behavior. The association among IMS findings, histopathological diagnoses, and clinical groups was assessed. RESULTS: There was a strong association between a diagnosis of Spitzoid melanoma by IMS and lesions categorized as clinical groups 2, 3, and 4 (recurrence of disease, metastases, or death) compared with clinical group 1 (no recurrence or metastasis beyond a sentinel node) (P
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En línea:
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http://doi.org/10.1016/j.jaad.2016.07.007
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