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Título:
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Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in
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Autores:
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Rauner, Martina ;
Franke, Kristin ;
Murray, Marta ;
Singh, Rashim-Pal ;
Hiram-Bab, Sahar ;
Platzbecker, Uwe ;
Gassmann, Max ;
Socolovsky, Merav ;
Neumann, Drorit ;
Gabet, Yankel ;
Chavakis, Triantafyllos ;
Hofbauer, Lorenz-C. ;
Wielockx, Ben
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Tipo de documento:
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texto impreso
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Editorial:
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American Society for Bone and Mineral Research, 2019-02-06T14:45:58Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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The main oxygen sensor hypoxia inducible factor (HIF) prolyl hydroxylase 2 (PHD2) is a critical regulator of tissue homeostasis during erythropoiesis, hematopoietic stem cell maintenance, and wound healing. Recent studies point toward a role for the PHD2-erythropoietin (EPO) axis in the modulation of bone remodeling, even though the studies produced conflicting results. Here, we used a number of mouse strains deficient of PHD2 in different cell types to address the role of PHD2 and its downstream targets HIF-1alpha and HIF-2alpha in bone remodeling. Mice deficient for PHD2 in several cell lineages, including
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En línea:
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http://doi.org/10.1002/jbmr.2857
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