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Título:
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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
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Autores:
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Stucki, David ;
Brites, Daniela ;
Jeljeli, Leila ;
Coscolla, Mireia ;
Liu, Qingyun ;
Trauner, Andrej ;
Fenner, Lukas ;
Rutaihwa, Liliana ;
Borrell, Sonia ;
Luo, Tao ;
Gao, Qian ;
Kato-Maeda, Midori ;
Ballif, Marie ;
Egger, Matthias ;
Macedo, Rita ;
Mardassi, Helmi ;
Moreno, Milagros ;
Tudo-Vilanova, Griselda ;
Fyfe, Janet ;
Globan, Maria ;
Thomas, Jackson ;
Jamieson, Frances ;
Guthrie, Jennifer-L. ;
Asante-Poku, Adwoa ;
Yeboah-Manu, Dorothy ;
Wampande, Eddie ;
Ssengooba, Willy ;
Joloba, Moses ;
Henry-Boom, W. ;
Basu, Indira ;
Bower, James ;
Saraiva, Margarida ;
Vaconcellos, Sidra-E. G. ;
Suffys, Philip ;
Koch, Anastasia ;
Wilkinson, Robert ;
Gail-Bekker, Linda ;
Malla, Bijaya ;
Ley, Serej-D. ;
Beck, Hans-Peter ;
de-Jong, Bouke-C. ;
Toit, Kadri ;
Sanchez-Padilla, Elisabeth ;
Bonnet, Maryline ;
Gil-Brusola, Ana ;
Frank, Matthias ;
Penlap-Beng, Veronique-N. ;
Eisenach, Kathleen ;
Alani, Issam ;
Wangui-Ndung'u, Perpetual ;
Revathi, Gunturu ;
Gehre, Florian ;
Akter, Suriya ;
Ntoumi, Francine ;
Stewart-Isherwood, Lynsey ;
Ntinginya, Nyanda-E. ;
Rachow, Andrea ;
Hoelscher, Michael ;
Cirillo, Daniela-Maria ;
Skenders, Girts ;
Hoffner, Sven ;
Bakonyte, Daiva ;
Stakenas, Petras ;
Diel, Roland ;
Crudu, Valeriu ;
Moldovan, Olga ;
Al-Hajoj, Sahal ;
Otero, Larissa ;
Barletta, Francesca ;
Jane-Carter, E. ;
Diero, Lameck ;
Supply, Philip ;
Comas, Inaki ;
Niemann, Stefan ;
Gagneux, Sebastien
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Tipo de documento:
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texto impreso
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Editorial:
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Nature Research, 2019-02-06T14:48:07Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
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En línea:
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http://doi.org/10.1038/ng.3704
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