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Título:
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Genomic ancestry, CYP2D6, CYP2C9 and CYP2C19 among Latin-Americans
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Autores:
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Rodrigues-Soares, Fernanda ;
Penas-Lledo, Eva M. ;
Tarazona-Santos, Eduardo ;
Sosa-Macias, Martha ;
Teran, Enrique ;
Lopez-Lopez, Marisol ;
Rodeiro, Idania ;
Moya, Graciela E. ;
Calzadilla, Luis R. ;
Ramirez-Roa, Ronald ;
Grazina, Manuela ;
Estevez-Carrizo, Francisco E. ;
Barrantes, Ramiro ;
Llerena, Adrian
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Tipo de documento:
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texto impreso
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Editorial:
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American Society for Clinical Pharmacology and Therapeutics, 2019-08-08T15:23:45Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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We present the distribution of CYP2D6, CYP2C9 and CYP2C19 variants and predicted phenotypes in 33 native and admixed populations from Ibero-America (n>6,000) in the context of genetic ancestry (n=3,387). Continental ancestries are the major determinants of frequencies of the increased-activity allele CYP2C19*17 and CYP2C19 gUMs (negatively associated with Native American ancestry), decreased-activity alleles CYP2D6*41 and CYP2C9*2 (positively associated with European ancestry), and decreased-activity alleles CYP2D6*17 and CYP2D6*29 (positively associated with African ancestry). For the rare alleles CYP2C9*2 and CYPC19*17, European admixture accounts for their presence in Native American populations, but rare alleles CYP2D6*5 (null-activity), CYP2D6-multiplication alleles (increased activity) and CYP2C9*3 (decreased-activity) were present in the pre-Columbian Americas. The study of a broad spectrum of Native American populations from different ethno-linguistic groups shows how autochthonous diversity shaped the distribution of pharmaco-alleles and give insights on the prevalence of clinically relevant phenotypes associated with drugs such as paroxetine, tamoxifen, warfarin and clopidogrel.
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En línea:
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http://doi.org/10.1002/cpt.1598
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