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Título:
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Factors predictive of serious infections over time in systemic lupus erythematosus patients: data from a multi-ethnic, multi-national, Latin American lupus cohort
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Autores:
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Pimentel-Quiroz, V. R. ;
Ugarte-Gil, M. F. ;
Harvey, G. B. ;
Wojdyla, D. ;
Pons-Estel, G. J. ;
Quintana, R. ;
Esposto, A. ;
García, M. A. ;
Catoggio, L. J. ;
Cardiel, M. H. ;
Barile, L. A. ;
Amigo, M.-C. ;
Sato, E. ;
Bonfa, E. ;
Borba, E. ;
Lavras Costallat, L. T. ;
Neira, O. J. ;
Massardo, L. ;
Guibert-Toledano, M. ;
Chacon-Diaz, R. ;
Alarcon, G. S. ;
Pons-Estel, B. A. ;
Soriano, Enrique R. ;
Ceballos Recalde, Maria Flavia ;
Velozo, Edson ;
Manni, Jorge A. ;
Grimaudo, Sebastian ;
Sarano, Judith ;
Maldonado-Cocco, Jose A. ;
Arriola, Maria S. ;
Gomez, Graciela ;
Ines Marcos, Ana ;
Carlos Marcos, Juan ;
Scherbarth, Hugo R. ;
Lopez, Jorge A. ;
Motta, Estela L. ;
Drenkard, Cristina ;
Gamron, Susana ;
Buliubasich, Sandra ;
Onetti, Laura ;
Caeiro, Francisco ;
Alvarellos, Alejandro ;
Saurit, Verónica ;
Gentiletti, Silvana ;
Quagliatto, Norberto ;
Gentiletti, Alberto A. ;
Machado, Daniel ;
Abdala, Marcelo ;
Palatnik, Simon ;
Berbotto, Guillermo A. ;
Battagliotti, Carlos A. ;
Souza, Alexandre Wagner S. ;
Bertolo, Manoel Barros ;
Coimbra, Ibsen Bellini ;
Tavares Brenol, João C. ;
Monticielo, Odirlei ;
Xavier, Ricardo ;
Cavalcanti, Fernando de Souza ;
Branco Duarte, Angela Luzia ;
Lopes Marques, Claudia Diniz ;
da Silva, Nilzio Antonio ;
de O e Silva, Ana Carolina ;
Pacheco, Tatiana Ferracine ;
Fernando Molina-Restrepo, Jose ;
Molina-Lopez, Javier ;
Vásquez, Gloria ;
Ramirez, Luis A. ;
Uribe, Oscar ;
Iglesias-Gamarra, Antonio ;
Iglesias-Rodriguez, Antonio ;
Egea-Bermejo, Eduardo ;
Guzman-Moreno, Renato A. ;
Restrepo-Suarez, Jose F. ;
Alberto Reyes-Llerena, Gil ;
Hernandez-Martinez, Alfredo ;
Jacobelli, Sergio ;
Guzman, Leonardo R. ;
Garcia-Kutzbach, Abraham ;
Castellanos, Claudia ;
Cajas, Erwin ;
Pascual-Ramos, Virginia ;
Silveira, Luis H. ;
Garcia de la Torre, Ignacio ;
Orozco-Barocio, Gerardo ;
Estrada-Contreras, Magali L. ;
Sauza del Pozo, Maria Josefina ;
Aranda Baca, Laura E. ;
Urenda Quezada, Adelfia ;
Huerta-Yanez, Guillermo F. ;
Acevedo-Vazquez, Eduardo M. ;
Luis Alfaro-Lozano, Jose ;
Cucho-Venegas, Jorge M. ;
Ines Segami, Maria ;
Chung, Cecilia P. ;
Alva-Linares, Magaly ;
Abadi, Isaac ;
Rangel, Neriza ;
Al Snih Al Snih, Soham ;
Esteva-Spinetti, Maria H. ;
Vivas, Jorge
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Tipo de documento:
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texto impreso
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Editorial:
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Sage publications, 2019-08-08T15:23:46Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Aim: The aim of this study was to identify factors predictive of serious infections over time in patients with systemic lupus erythematosus (SLE). Methods: A multi-ethnic, multi-national Latin American SLE cohort was studied. Serious infection was defined as one that required hospitalization, occurred during a hospitalization or led to death. Potential predictors included were sociodemographic factors, clinical manifestations (per organ involved, lymphopenia and leukopenia, independently) and previous infections at baseline. Disease activity (SLEDAI), damage (SLICC/ACR Damage Index), non-serious infections, glucocorticoids, antimalarials (users and non-users), and immunosuppressive drugs use; the last six variables were examined as time-dependent covariates. Cox regression models were used to evaluate the predictors of serious infections using a backward elimination procedure. Univariable and multivariable analyses were performed. Results: Of the 1243 patients included, 1116 (89.8%) were female. The median (interquartile range) age at diagnosis and follow-up time were 27 (20–37) years and 47.8 (17.9–68.6) months, respectively. The incidence rate of serious infections was 3.8 cases per 100 person-years. Antimalarial use (hazard ratio: 0.69; 95% confidence interval (CI): 0.48–0.99; p = 0.0440) was protective, while doses of prednisone >15 and ?60 mg/day (hazard ratio: 4.18; 95 %CI: 1.69–10.31; p = 0.0019) and >60 mg/day (hazard ratio: 4.71; 95% CI: 1.35–16.49; p = 0.0153), use of methylprednisolone pulses (hazard ratio: 1.53; 95% CI: 1.10–2.13; p = 0.0124), increase in disease activity (hazard ratio: 1.03; 95% CI: 1.01–1.04; p = 0.0016) and damage accrual (hazard ratio: 1.22; 95% CI: 1.11–1.34; p
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En línea:
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http://doi.org/10.1177/0961203319860579
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