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Título:
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The FAS-670 AA genotype is associated with high proviral load in peruvian HAM/TSP patients
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Autores:
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Rosado, Jason ;
Morales, Sandra ;
Lopez, Giovanni ;
Clark, Daniel ;
Verdonck, Kristien ;
Gotuzzo, Eduardo ;
Van Camp, Guy ;
Talledo, Michael
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Tipo de documento:
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texto impreso
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Editorial:
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Wiley, 2019-01-25T16:03:21Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Human T?lymphotropic virus 1 (HTLV?1) is the etiologic agent of the HTLV?1?associated myelopathy/tropical spastic paraparesis (HAM/TSP). Apoptosis is a mechanism of defense elicited by many triggers, including cross?linking of the FAS receptor expressed in viruses?infected cells, and the ligand FASL presented by T?cytotoxic cells. As HAM/TSP has been associated with high levels of proviral load (PVL), we hypothesized that certain genotypes of single?nucleotide polymorphisms (SNPs) associated with a decreased protein expression of FAS and FASL could be risk factors for this disease. Three SNPs: FAS?670A/G (rs1800682), FAS?1377G/A (rs2234767), and FASL?844C/T (rs763110) were analyzed in 73 HAM/TSP patients and 143 HTLV?1 asymptomatic carriers. Ancestry informative markers were used to adjust for ethnicity through a principal component analysis. Gender, age, PVL, and the first three principal components were used as covariates. The FAS/FASL genotype distribution was not associated with HAM/TSP presence (P–>?0.05). The FAS?670 AA genotype was associated with high PVL in comparison to FAS?670 GG in HAM/TSP patients (P?=?0.015), while in asymptomatic carriers low levels of PVL were observed (P?>?0.05). Our findings suggest that rs1800682, rs2234767, and rs763110 genotypes are not associated with the presence of HAM/TSP, but that the FAS?670 AA genotype can promote higher PVL values in HAM/TSP patients.
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En línea:
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http://doi.org/10.1002/jmv.24681
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