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Título:
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Surveillance of Candida spp bloodstream infections: epidemiological trends and risk factors of death in two Mexican tertiary care hospitals
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Autores:
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Corzo-Leon, Dora E. ;
Alvarado-Matute, Tito ;
Colombo, Arnaldo L. ;
Cornejo-Juarez, Patricia ;
Cortes, Jorge ;
Echevarria, Juan I. ;
Guzman-Blanco, Manuel ;
Macias, Alejandro E. ;
Nucci, Marcio ;
Ostrosky-Zeichner, Luis ;
Ponce-de-Leon, Alfredo ;
Queiroz-Telles, Flavio ;
Santolaya, Maria E. ;
Thompson-Moya, Luis ;
Tiraboschi, Iris N. ;
Zurita, Jeannete ;
Sifuentes-Osornio, Jose
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Tipo de documento:
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texto impreso
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Editorial:
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Public Library of Science, 2020-06-10T18:12:18Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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INTRODUCTION: Larger populations at risk, broader use of antibiotics and longer hospital stays have impacted on the incidence of Candida sp. bloodstream infections (CBSI). OBJECTIVE: To determine clinical and epidemiologic characteristics of patients with CBSI in two tertiary care reference medical institutions in Mexico City. DESIGN: Prospective and observational laboratory-based surveillance study conducted from 07/2008 to 06/2010. METHODS: All patients with CBSI were included. Identification and antifungal susceptibility were performed using CLSI M27-A3 standard procedures. Frequencies, Mann-Whitney U test or T test were used as needed. Risk factors were determined with multivariable analysis and binary logistic regression analysis. RESULTS: CBSI represented 3.8% of nosocomial bloodstream infections. Cumulative incidence was 2.8 per 1000 discharges (incidence rate: 0.38 per 1000 patient-days). C. albicans was the predominant species (46%), followed by C. tropicalis (26%). C. glabrata was isolated from patients with diabetes (50%), and elderly patients. Sixty-four patients (86%) received antifungals. Amphotericin-B deoxycholate (AmBD) was the most commonly used agent (66%). Overall mortality rate reached 46%, and risk factors for death were APACHE II score >/= 16 (OR = 6.94, CI95% = 2.34-20.58, p
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En línea:
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http://doi.org/10.1371/journal.pone.0097325
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