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Título:
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Combined predictors of neurodevelopment in very low birth weight preterm infants
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Autores:
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Medina-Alva, Pilar ;
Duque, Kevin R. ;
Zea-Vera, Alonso ;
Bellomo, Sicilia ;
Carcamo, Cesar ;
Guillen-Pinto, Daniel ;
Rivas, Maria ;
Tori, Alfredo ;
Zegarra, Jaime ;
Cam, Luis ;
Castaneda, Anne ;
Villavicencio, Aasith ;
Ochoa, Theresa J.
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Tipo de documento:
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texto impreso
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Editorial:
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Elsevier, 2019-07-04T16:59:25Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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OBJECTIVE: To evaluate the combined prognostic value of neurological examination, head circumference and cranial ultrasound for neurodevelopmental delay (NDD) in very low birth weight (VLBW, /=2 deviant items of Hammersmith neurological examination), microcephaly and major ultrasound abnormalities, each performed at term age, were evaluated as predictors of NDD in a multivariable Poisson model. RESULTS: 35/132 infants (26.5%) had NDD. In the multivariable analysis, microcephaly (RR, 3.2; 95% CI, 1.6-6.7) and major ultrasound abnormalities (RR, 2.7; 95% CI, 1.3-5.7) were associated to NDD. The combination of the two tests showed the highest positive predictive value (100%; 95% CI, 51%-100%), while the combination of normal neurological examination, no major US findings and normal head size at term showed the highest negative predictive value (89%; 95% CI, 78%-95%). The maximum under receiver operating characteristic curve area was for microcephaly or major ultrasound abnormalities (AUC 0.74 (0.65-0.83)). CONCLUSION: The combination of head circumference, cranial ultrasound and neurological examination at term age is useful to predict NDD in VLBW preterm infants.
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En línea:
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http://doi.org/10.1016/j.earlhumdev.2019.01.019
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