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Título:
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A case control study to identify community venues associated with genetically clustered Multidrug-resistant Tuberculosis disease in Lima, Peru
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Autores:
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Bui, David P. ;
Oren, Eyal ;
Roe, Denise J. ;
Brown, Heidi E. ;
Harris, Robin B. ;
Knight, Gwenan M. ;
Gilman, Robert H. ;
Grandjean, Louis
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Tipo de documento:
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texto impreso
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Editorial:
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Oxford University Press, 2018-11-30T02:09:28Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Background: The majority of tuberculosis transmission occurs in community settings. The primary aim of this study was to assess the association between exposure to community venues and multidrug-resistant tuberculosis (MDR-TB) disease. The secondary aim was to describe the social networks of MDR-TB cases and controls. Methods: This case-control study was conducted in Lima, Peru. We recruited lab-confirmed MDR-TB cases and community controls matched on age and sex. Whole-genome sequencing was used to identify genetically-clustered cases. Venue-tracing interviews (nonblinded) were conducted to enumerate community venues frequented by participants. Logistic regression was used to assess the association between MDR-TB disease and person-time spent in community venues. A location-based social network was constructed with respondents connected if they reported frequenting the same venue and an exponential random graph model (ERGM) was fitted to model the network. Results: We enrolled 59 cases and 65 controls. Participants reported 729 unique venues. Mean number of venues reported was similar in both groups (P=0.92). Cases reported spending more person-time (hours) in healthcare and transportation venues than controls (P
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En línea:
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http://doi.org/10.1093/cid/ciy746
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