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Título:
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A Fas(hi) Lymphoproliferative Phenotype Reveals Non-Apoptotic Fas Signaling in HTLV-1-Associated Neuroinflammation
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Autores:
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Menezes, Soraya Maria ;
Leal, Fabio E. ;
Dierckx, Tim ;
Khouri, Ricardo ;
Decanine, Daniele ;
Silva-Santos, Gilvaneia ;
Schnitman, Saul V. ;
Kruschewsky, Ramon ;
Lopez, Giovanni ;
Alvarez, Carolina ;
Talledo, Michael ;
Gotuzzo, Eduardo ;
Nixon, Douglas F. ;
Vercauteren, Jurgen ;
Brassat, David ;
Liblau, Roland ;
Vandamme, Anne Mieke ;
Galvao-Castro, Bernardo ;
Van Weyenbergh, Johan
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Tipo de documento:
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texto impreso
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Editorial:
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Frontiers Media, 2019-01-25T15:02:14Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Human T-cell lymphotropic virus (HTLV)-1 was the first human retrovirus to be associated to cancer, namely adult T-cell leukemia (ATL), but its pathogenesis remains enigmatic, since only a minority of infected individuals develops either ATL or the neuroinflammatory disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). A functional FAS -670 polymorphism in an interferon (IFN)-regulated STAT1-binding site has been associated to both ATL and HAM/TSP susceptibility. Fas(hi) T stem cell memory (Tscm) cells have been identified as the hierarchical apex of ATL, but have not been investigated in HAM/TSP. In addition, both FAS and STAT1 have been identified in an IFN-inducible HAM/TSP gene signature, but its pathobiological significance remains unclear. We comprehensively explored Fas expression (protein/mRNA) and function in lymphocyte activation, apoptosis, proliferation, and transcriptome, in PBMC from a total of 47 HAM/TSP patients, 40 asymptomatic HTLV-1-infected individuals (AC), and 58
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En línea:
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http://doi.org/10.3389/fimmu.2017.00097
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