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Título:
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Metformin use is associated with a lower risk of osteoporosis in adult women independent of type 2 diabetes mellitus and obesity. REDLINC IX study
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Autores:
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Blümel, Juan E. ;
Arteaga, Eugenio ;
Aedo, Sócrates ;
Arriola-Montenegro, José ;
López, Marcela ;
Martino, Mabel ;
Miranda, Carlos ;
Miranda, Octavio ;
Mostajo, Desireé ;
Ñañez, Mónica ;
Ojeda, Eliana ;
Pilnik, Susana ;
Rojas, José ;
Salinas, Carlos ;
Sosa, Lida ;
Spritzer, Poli M. ;
Tserotas, Konstantinos ;
Vallejo, María S. ;
Belardo, Alejandra ;
Fighera, Tayane M. ;
Chedraui, Peter
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Tipo de documento:
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texto impreso
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Editorial:
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Taylor & Francis, 2020-07-14T00:00:57Z
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Nota general:
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info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Metformin may decrease cell senescence, including bone; hence we aimed at evaluating the association between metformin use and osteoporosis. This was a cross-sectional study carried out in 1259 Latin American adult women aged 40 or more who were not on anti-osteoporotic drugs, were on metformin and had a bone densitometry performed. Of the whole sample, 40.3% reported being on metformin (at least 1 year), 30.2% had type 2 diabetes mellitus and 22.6% had osteoporosis. Median (interquartile range) body mass index (BMI) for the whole cohort was 27.7 (4.6) kg/m2 and 30.2% had type 2 diabetes mellitus. Current use of hormone therapy, calcium, and vitamin D corresponded respectively to 10.7%, 47.7%, and 43.1% of all surveyed women. A logistic regression model was used to analyze the association of osteoporosis with various covariates incorporated into the model such as age (OR: 1.07, 95% CI: 1.05–1.09), BMI (OR: 0.92, 95% CI: 0.89–0.96) and metformin use (OR: 0.44, 95% CI: 0.32–0.59). Metformin use, regardless of the presence of type 2 diabetes or obesity, was associated with a lower risk of osteoporosis in adult women. We propose that one explanation for this observation could be the effect of the drug over cellular senescence.
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/8236
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