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Título:
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Population Genetics of Plasmodium vivax in the Peruvian Amazon
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Autores:
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Delgado-Ratto, Christopher ;
Gamboa, Dionicia ;
Soto-Calle, Veronica-E. ;
Van-den-Eede, Peter ;
Torres, Eliana ;
Sanchez-Martinez, Luis ;
Contreras-Mancilla, Juan ;
Rosanas-Urgell, Anna ;
Rodriguez-Ferrucci, Hugo ;
Llanos-Cuentas, Alejandro ;
Erhart, Annette ;
Van-Geertruyden, Jean-Pierre ;
D'Alessandro, Umberto
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Tipo de documento:
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texto impreso
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Editorial:
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Public Library of Science, 2019-02-06T14:45:12Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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BACKGROUND: Characterizing the parasite dynamics and population structure provides useful information to understand the dynamic of transmission and to better target control interventions. Despite considerable efforts for its control, vivax malaria remains a major health problem in Peru. In this study, we have explored the population genetics of Plasmodium vivax isolates from Iquitos, the main city in the Peruvian Amazon, and 25 neighbouring peri-urban as well as rural villages along the Iquitos-Nauta Road. METHODOLOGY/ RESULTS: From April to December 2008, 292 P. vivax isolates were collected and successfully genotyped using 14 neutral microsatellites. Analysis of the molecular data revealed a similar proportion of monoclonal and polyclonal infections in urban areas, while in rural areas monoclonal infections were predominant (p = 0.002). Multiplicity of infection was higher in urban (MOI = 1.5-2) compared to rural areas (MOI = 1) (p = 0.003). The level of genetic diversity was similar in all areas (He = 0.66-0.76, p = 0.32) though genetic differentiation between areas was substantial (PHIPT = 0.17, p
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En línea:
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http://doi.org/10.1371/journal.pntd.0004376
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