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Título:
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Rationing tests for drug-resistant tuberculosis - who are we prepared to miss?
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Autores:
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Martin, Laura J. ;
Roper, Martha H. ;
Grandjean, Louis ;
Gilman, Robert H. ;
Coronel, Jorge ;
Caviedes, Luz ;
Friedland, Jon S. ;
Moore, David A. J.
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Tipo de documento:
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texto impreso
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Editorial:
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BMC, 2019-02-06T14:45:55Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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BACKGROUND: Early identification of patients with drug-resistant tuberculosis (DR-TB) increases the likelihood of treatment success and interrupts transmission. Resource-constrained settings use risk profiling to ration the use of drug susceptibility testing (DST). Nevertheless, no studies have yet quantified how many patients with DR-TB this strategy will miss. METHODS: A total of 1,545 subjects, who presented to Lima health centres with possible TB symptoms, completed a clinic-epidemiological questionnaire and provided sputum samples for TB culture and DST. The proportion of drug resistance in this population was calculated and the data was analysed to demonstrate the effect of rationing tests to patients with multidrug-resistant TB (MDR-TB) risk factors on the number of tests needed and corresponding proportion of missed patients with
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En línea:
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http://doi.org/10.1186/s12916-016-0576-8
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