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Título:
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Better Health-Related Quality of Life in Systemic Lupus Erythematosus Predicted by Low Disease Activity State/Remission: Data From the Peruvian Almenara Lupus Cohort
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Autores:
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Ugarte-Gil, M.F. ;
Gamboa-Cárdenas, R.V. ;
Reátegui-Sokolova, C. ;
Medina-Chinchón, M. ;
Zevallos, F. ;
Elera-Fitzcarrald, C. ;
Pimentel-Quiroz, V. ;
Cucho-Venegas, J.M. ;
Rodriguez-Bellido, Z. ;
Pastor-Asurza, C.A. ;
Alarcón, G.S. ;
Perich-Campos, R.
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Tipo de documento:
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texto impreso
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Editorial:
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John Wiley and Sons Inc., 2020-12-14T16:10:20Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Objective: To determine if low disease activity state (LDAS)/remission predicts a better health-related quality of life (HRQoL). Methods: Patients with systemic lupus erythematosus from a single center and having completed at least 2 visits were included. Visits were performed every 6 months. HRQoL was measured with the LupusQoL questionnaire. The definition of remission included a Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score of 0, prednisone daily dosage of ?5 mg/day, and immunosuppressive drugs on maintenance dose. LDAS was defined as a SLEDAI-2K score of ?4, prednisone daily dosage of ?7.5 mg/day, and immunosuppressive drugs as maintenance therapy. For these analyses, remission and LDAS were combined as one variable. Generalized estimating equations were calculated, using as the outcome 1 of each of the 8 components of the LupusQoL questionnaire in the subsequent visit and the activity state in the previous visit. Multivariable models were adjusted for possible confounders. Results: A total of 243 patients were included. During the follow-up, 590 visits (61.6%) were categorized as LDAS/remission. LDAS/remission predicted a better HRQoL in the components of physical health (B = 4.17 [95% confidence interval (95% CI) 1.20, 7.14]; P = 0.006), pain (B = 6.47 [95% CI 3.18, 9.76]; P
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/8835
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