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Título:
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Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma
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Autores:
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Ferrufino-Schmidt, Maria C. ;
Medeiros, L. Jeffrey ;
Liu, Hui ;
Clemens, Mark W. ;
Hunt, Kelly K. ;
Laurent, Camille ;
Lofts, Julian ;
Amin, Mitual B. ;
Chai, Siaw Ming ;
Morine, Angela ;
Di Napoli, Arianna ;
Dogan, Ahmet ;
Parkash, Vinita ;
Bhagat, Govind ;
Tritz, Denise ;
Quesada, Andres E. ;
Pina-Oviedo, Sergio ;
Hu, Qinlong ;
Garcia-Gomez, Francisco J. ;
Borrero, Juan Jose ;
Horna, Pedro ;
Thakral, Beenu ;
Narbaitz, Marina ;
Hughes, R. Condon, III ;
Yang, Li-Jun ;
Fromm, Jonathan R. ;
Wu, David ;
Zhang, Da ;
Sohani, Aliyah R. ;
Hunt, John ;
Vadlamani, Indira U. ;
Morgan, Elizabeth A. ;
Ferry, Judith A. ;
Szigeti, Reka ;
Tardio, Juan C. ;
Granados, Rosario ;
Dertinger, Susanne ;
Offner, Felix A. ;
Pircher, Andreas ;
Hosry, Jeff ;
Young, Ken H. ;
Miranda, Roberto N.
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Tipo de documento:
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texto impreso
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Editorial:
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Lippincott, Williams & Wilkins, 2018-11-30T23:41:32Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare T-cell lymphoma that arises around breast implants. Most patients manifest with periprosthetic effusion, whereas a subset of patients develops a tumor mass or lymph node involvement (LNI). The aim of this study is to describe the pathologic features of lymph nodes from patients with BI-ALCL and assess the prognostic impact of LNI. Clinical findings and histopathologic features of lymph nodes were assessed in 70 patients with BI-ALCL. LNI was defined by the histologic demonstration of ALCL in lymph nodes. Fourteen (20%) patients with BI-ALCL had LNI, all lymph nodes involved were regional, the most frequent were axillary (93%). The pattern of involvement was sinusoidal in 13 (92.9%) cases, often associated with perifollicular, interfollicular, and diffuse patterns. Two cases had Hodgkin-like patterns. The 5-year overall survival was 75% for patients with LNI and 97.9% for patients without LNI at presentation (P = 0.003). Six of 49 (12.2%) of patients with tumor confined by the capsule had LNI, compared with LNI in 8/21 (38%) patients with tumor beyond the capsule. Most patients with LNI achieved complete remission after various therapeutic approaches. Two of 14 (14.3%) patients with LNI died of disease compared with 0/56 (0%) patients without LNI. Twenty percent of patients with BI-ALCL had LNI by lymphoma, most often in a sinusoidal pattern. We conclude that BI-ALCL beyond capsule is associated with a higher risk of LNI. Involvement of lymph nodes was associated with decreased overall survival. Misdiagnosis as Hodgkin lymphoma is a pitfall.
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En línea:
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http://doi.org/10.1097/PAS.0000000000000985
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