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Título:
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Clinical features, damage accrual, and survival in patients with familial systemic lupus erythematosus: data from a multi-ethnic, multinational Latin American lupus cohort
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Autores:
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Quintana, R. ;
Pons-Estel, G.J. ;
Roberts, K. ;
Sacnún, M. ;
Serrano, R. ;
Nieto, R. ;
Conti, S. ;
Gervasoni, V. ;
Catoggio, L.J. ;
Soriano, E.R. ;
Scolnik, M. ;
Garcia, M.A. ;
Alvarellos, A. ;
Saurit, V. ;
Berbotto, G.A. ;
Sato, E.I. ;
Costallat, L.T.L. ;
Neto, E.F.B. ;
Bonfa, E. ;
Xavier, R.M. ;
de Oliveira e Silva Montandon, A.C. ;
Molina-Restrepo, J.F. ;
Iglesias-Gamarra, A. ;
Guibert-Toledano, M. ;
Reyes-Llerena, G.A. ;
Massardo, L. ;
Neira, O.J. ;
Cardiel, M.H. ;
Barile-Fabris, L.A. ;
Amigo, M.-C. ;
Silveira, L.H. ;
Torre, I.G.D.L. ;
Acevedo-Vásquez, E.M. ;
Ugarte-Gil, M.F. ;
Alfaro-Lozano, J.L. ;
Segami, M.I. ;
Chacon-Diaz, R. ;
Esteva-Spinetti, M.H. ;
Gomez-Puerta, J.A. ;
Alarcón, G.S. ;
Pons-Estel, B.A.
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Tipo de documento:
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texto impreso
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Editorial:
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SAGE PUBLICATIONS LTD, 2020-12-14T16:10:05Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Objectives: This study aimed to compare the clinical features, damage accrual, and survival of patients with familial and sporadic systemic lupus erythematosus (SLE). Methods: A multi-ethnic, multinational Latin American SLE cohort was studied. Familial lupus was defined as patients with a first-degree SLE relative; these relatives were interviewed in person or by telephone. Clinical variables, disease activity, damage, and mortality were compared. Odds ratios (OR) and 95% confidence intervals (CI) were estimated. Hazard ratios (HR) were calculated using Cox proportional hazard adjusted for potential confounders for time to damage and mortality. Results: A total of 66 (5.6%) patients had familial lupus, and 1110 (94.4%) had sporadic lupus. Both groups were predominantly female, of comparable age, and of similar ethnic distribution. Discoid lupus (OR = 1.97; 95% CI 1.08–3.60) and neurologic disorder (OR = 1.65; 95% CI 1.00–2.73) were significantly associated with familial SLE; pericarditis was negatively associated (OR = 0.35; 95% CI 0.14–0.87). The SLE Disease Activity Index and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) were similar in both groups, although the neuropsychiatric (45.4% vs. 33.5%; p = 0.04) and musculoskeletal (6.1% vs. 1.9%; p = 0.02) domains of the SDI were more frequent in familial lupus. They were not retained in the Cox models (by domains). Familial lupus was not significantly associated with damage accrual (HR = 0.69; 95% CI 0.30–1.55) or mortality (HR = 1.23; 95% CI 0.26–4.81). Conclusion: Familial SLE is not characterized by a more severe form of disease than sporadic lupus. We also observed that familial SLE has a higher frequency of discoid lupus and neurologic manifestations and a lower frequency of pericarditis. © The Author(s) 2020.
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/8772
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