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Título:
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Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
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Autores:
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Barrera Tomas, M. ;
Tomas Chota, G.E. ;
Sheen Cortavarría, P. ;
Fuentes Bonilla, P. ;
Inocente Camones, M.A. ;
Santiago Contreras, J.
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Tipo de documento:
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texto impreso
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Editorial:
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Universidad Nacional de Colombia, 2019-02-22T14:54:00Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its antiMycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 ?g/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 ?g/mL respectively.
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En línea:
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http://doi.org/10.15446/rev.colomb.quim.v46n3.61980
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