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Título:
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Mycobacterium tuberculosis-specific cytokine biomarkers for the diagnosis of childhood TB in a TB-endemic setting
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Autores:
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Sudbury, E.L. ;
Otero, L. ;
Tebruegge, M. ;
Messina, N.L. ;
Seas, C. ;
Montes, M. ;
Rìos, J. ;
Germano, S. ;
Gardiner, K. ;
Clifford, V. ;
Gotuzzo, E. ;
Curtis, N.
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Tipo de documento:
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texto impreso
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Editorial:
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Elsevier, 2019-07-04T17:00:19Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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The tuberculin skin test and interferon-gamma release assays have limitations in diagnosing tuberculosis (TB), particularly in children. This study investigated the performance of candidate M. tuberculosis-specific cytokine biomarkers for TB in children in a TB-endemic setting. A total of 237 children with a household contact with smear-positive pulmonary TB were recruited. Importantly, a group of children with illnesses other than TB (sick controls) was included to assess specificity. Median IFN-?, IL-1ra, IL-2, IL-13, IP-10, MIP-1? and TNF-? responses were significantly higher in children with active TB and latent TB infection (LTBI) than in both healthy and sick control children. Three of these cytokines – IL-2, IL-13 and IP-10 – showed better performance characteristics than IFN-?, with IL-2 achieving positive and negative predictive values of 97.7% and 90.7%, respectively. Furthermore, IL-1ra and TNF-? responses differed significantly between active TB and LTBI cases, suggesting that they may be stage-specific biomarkers. Our data indicate that incorporating these biomarkers into future blood-based TB assays could result in substantial performance gains. © 2019
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En línea:
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http://doi.org/10.1016/j.jctube.2019.100102
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