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Título:
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Etiological Role and Repeated Infections of Sapovirus among Children Aged Less than 2 Years in a Cohort Study in a Peri-urban Community of Peru
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Autores:
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Liu, Xiaofang ;
Jahuira, Helena ;
Gilman, Robert H. ;
Alva, Alicia ;
Cabrera, Lilia ;
Okamoto, Michiko ;
Xu, Hang ;
Windle, Henry J. ;
Kelleher, Dermot ;
Varela, Marco ;
Verastegui, Manuela ;
Calderón, Maritza ;
Sanchez, Gerardo ;
Sarabia, Vanessa ;
Ballard, Sarah B. ;
Bern, Caryn ;
Mayta, Holger ;
Crabtree, Jean E. ;
Cama, Vitaliano ;
Saito, Mayuko ;
Oshitani, Hitoshi
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Tipo de documento:
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texto impreso
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Editorial:
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American Society for Microbiology, 2019-02-06T14:45:36Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Human sapovirus has been shown to be one of the most important etiologies in pediatric patients with acute diarrhea. However, very limited data are available about the causative roles and epidemiology of sapovirus in community settings. A nested matched case-control study within a birth cohort study of acute diarrhea in a peri-urban community in Peru from 2007 to 2010 was conducted to investigate the attributable fraction (AF) and genetic diversity of sapovirus. By quantitative reverse transcription-real-time PCR (qPCR) sapovirus was detected in 12.4% (37/299) of diarrheal and 5.7% (17/300) of nondiarrheal stools (P = 0.004). The sapovirus AF (7.1%) was higher in the second year (13.2%) than in the first year (1.4%) of life of children. Ten known genotypes and one novel cluster (n = 5) within four genogroups (GI, GII, GIV, and GV) were identified by phylogenetic analysis of a partial VP1 gene. Further sequence analysis of the full VP1 gene revealed a possible novel genotype, tentatively named GII.8. Notably, symptomatic reinfections with different genotypes within the same (n = 3) or different (n = 5) genogroups were observed in eight children. Sapovirus exhibited a high attributable burden for acute gastroenteritis, especially in the second year of life, of children in a Peruvian community. Further large-scale studies are needed to understand better the global burden, genetic diversity, and repeated infections of sapovirus.
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En línea:
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http://doi.org/10.1128/JCM.03133-15
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