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Título:
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Discovery of Novel (Imidazo[1,2-a]pyrazin-6-yl)ureas as Antiproliferative Agents Targeting P53 in Non-small Cell Lung Cancer Cell Lines
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Autores:
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Bazin, Marc-Antoine ;
Rousseau, Benedicte ;
Marhadour, Sophie ;
Tomasoni, Christophe ;
Evenou, Pierre ;
Piessard, Sylvie ;
Vaisberg, Abraham J. ;
Ruchaud, Sandrine ;
Bach, Stephane ;
Roussakis, Christos ;
Marchand, Pascal
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Tipo de documento:
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texto impreso
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Editorial:
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International Institute of Anticancer Research, 2019-02-22T14:54:00Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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A series of (imidazo[1,2-a]pyrazin-6-yl)ureas were synthesized through 6-aminoimidazo[1,2-a]pyrazine as a key intermediate. 1-(Imidazo[1,2-a]pyrazin-6-yl)-3-(4-methoxy-phenyl) urea displayed a cytostatic activity against a nonsmall cell lung cancer cell line and was chosen for further mechanistic studies. Growth kinetics highlighted a selective dose-dependent response of P53-mutant NSCLC-N6-L16 cell line and overexpression of TP53 gene induced by this compound. These pharmacological data suggest a promising reactivation of p53 mutant in NSCLC-N6-L16 cell line.
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En línea:
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http://ar.iiarjournals.org/content/36/4/1621.full
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![Discovery of Novel (Imidazo[1,2-a]pyrazin-6-yl)ureas as Antiproliferative Agents Targeting P53 in Non-small Cell Lung Cancer Cell Lines](./styles/zen/images/no_image.jpg)
