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Título:
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Jaccoud's arthropathy in SLE: findings from a Latin American multiethnic population.
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Autores:
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Quintana, Rosana ;
Pons-Estel, Guillermo ;
Roberts, Karen ;
Sacnun, Monica ;
Berbotto, Guillermo ;
García, Mercedes A. ;
Saurit, Verónica ;
Barile-Fabris, Leonor ;
Acevedo-Vazquez, Eduardo M. ;
Tavares Brenol, João C. ;
Sato, Emilia I. ;
Iglesias, Antonio ;
Uribe, Oscar ;
Alarcon, Graciela ;
Pons-Estel, Bernardo A.
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Tipo de documento:
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texto impreso
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Editorial:
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BMJ Publishing Group, 2019-12-06T21:02:52Z
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Nota general:
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info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Objective: To compare the clinical, laboratory and outcome features of SLE patients with and without Jaccoud's arthropathy (JA) from the Grupo Latino Americano De Estudio del Lupus (GLADEL) cohort. Methods: 1480 patients with SLE [(34 centres, 9 Latin American countries with a recent diagnosis (=2 years)] constitute the GLADEL cohort. JA was defined as reducible deformity of the metacarpophalangeal axis, without radiographic erosions at any time. Within this cohort, a nested case-control study was carried out. Control was matched for age, gender and centre in a 1:3 proportion. The variables included were: sociodemographic, clinical and immunological features, disease activity, damage and mortality. Comparisons were performed with Wilcoxon and chi(2) tests for continuous and categorical variables, respectively. ORs and 95% CIs and Kaplan-Meier survival curve were estimated. Results: Of 1480 patients, 17 (1.1%) JA patients were identified; 16 (94.1%) of them were women, mean age: 31.0 years (SD 12.0). Five (29.4%) patients presented JA at SLE diagnosis and 12 (70.6%) after. The median follow-up time and all disease features were comparable in both groups except for a higher frequency of pneumonitis in the patients with JA [4 (23.5) vs 1 (2.0); p=0.012; (OR: 15.4; 95% CI 1.6 to 149.6)]. The SLE disease activity index, Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage Index and the Kaplan-Meier survival curve were similar in both groups. Conclusion: JA may tend to appear early in the course of SLE; it seems not to have an impact on disease activity, damage accrual or in survival.
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/7463
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