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Título:
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Detecting Mutations in the Mycobacterium tuberculosis Pyrazinamidase Gene pncA to Improve Infection Control and Decrease Drug Resistance Rates in Human Immunodeficiency Virus Coinfection
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Autores:
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Dudley, Matthew Z. ;
Sheen, Patricia ;
Gilman, Robert H. ;
Ticona, Eduardo ;
Friedland, Jon S. ;
Kirwan, Daniela E. ;
Caviedes, Luz ;
Rodriguez, Richard ;
Cabrera, Lilia Z. ;
Coronel, Jorge ;
Grandjean, Louis ;
Moore, David A. J. ;
Evans, Carlton A. ;
Huaroto, Luz ;
Chavez-Perez, Victor ;
Zimic, Mirko
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Tipo de documento:
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texto impreso
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Editorial:
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American Society of Tropical Medicine and Hygiene, 2019-02-06T14:45:12Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Hospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA) is a potent drug that effectively sterilizes persistent Mycobacterium tuberculosis bacilli. However, PZA resistance associated with mutations in the nicotinamidase/pyrazinamidase coding gene, pncA, is increasing. A total of 794 patient isolates obtained from four sites in Lima, Peru, underwent spoligotyping and drug resistance testing. In one of these sites, the HIV unit of Hospital Dos de Mayo (HDM), an isolation ward for HIV/TB coinfected patients opened during the study as an infection control intervention: circulating genotypes and drug resistance pre- and postintervention were compared. All other sites cared for
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En línea:
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http://doi.org/10.4269/ajtmh.15-0711
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