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Título:
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The application of cytokine expression assays to differentiate active from previously treated syphilis.
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Autores:
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Kojima, N. ;
Siebert, J. C. ;
Maecker, H. ;
Rosenberg-Hasson, Y. ;
Leon, S. R. ;
Vargas, S. K. ;
Konda, K. A. ;
Caceres, C. F. ;
Klausner, J. D.
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Tipo de documento:
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texto impreso
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Editorial:
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Oxford University Press, 2020-07-14T00:02:30Z
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Nota general:
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info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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To investigate the role of serum cytokine assays to distinguish between active from treated syphilis among serofast patients, we recruited individuals into a prospective cohort study. Participants underwent routine syphilis screening. We selected specimens from a majority cohort of serofast participants with treated and active syphilis. We analyzed specimens with a 62-cytokine multiplex bead-based enzyme-linked immunosorbent assay. Cytokines, BDNF and TNFB, were most predictive. We built a decision tree that was 82.4% accurate, 100% (95%CI: 82%-100%) sensitive, and 45% (95%CI, 18%-75%) specific. Our decision tree differentiated between serum specimens of serofast participants with treated syphilis and active syphilis.
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/8319
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