|
Título:
|
A Prospective Cohort Multicenter Study of Molecular Epidemiology and Phylogenomics of Staphylococcus aureus Bacteremia in Nine Latin American Countries
|
|
Autores:
|
Arias, Cesar A. ;
Reyes, Jinnethe ;
Carvajal, Lina Paola ;
Rincon, Sandra ;
Diaz, Lorena ;
Panesso, Diana ;
Ibarra, Gabriel ;
Rios, Rafael ;
Munita, Jose M. ;
Salles, Mauro J. ;
Alvarez-Moreno, Carlos ;
Labarca, Jaime ;
García, Coralith ;
Luna, Carlos M. ;
Mejia-Villatoro, Carlos ;
Zurita, Jeannete ;
Guzman-Blanco, Manuel ;
Rodriguez-Noriega, Eduardo ;
Narechania, Apurva ;
Rojas, Laura J. ;
Planet, Paul J. ;
Weinstock, George M. ;
Gotuzzo, Eduardo ;
Seas, Carlos
|
|
Tipo de documento:
|
texto impreso
|
|
Editorial:
|
American Society of Microbiology, 2019-01-25T15:02:14Z
|
|
Nota general:
|
info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
|
|
Idiomas:
|
Inglés
|
|
Palabras clave:
|
Editados por otras instituciones
,
Artículos
,
Artículos en revistas indizadas
|
|
Resumen:
|
Staphylococcus aureus is an important pathogen causing a spectrum of diseases ranging from mild skin and soft tissue infections to life-threatening conditions. Bloodstream infections are particularly important, and the treatment approach is complicated by the presence of methicillin-resistant S. aureus (MRSA) isolates. The emergence of new genetic lineages of MRSA has occurred in Latin America (LA) with the rise and dissemination of the community-associated USA300 Latin American variant (USA300-LV). Here, we prospectively characterized bloodstream MRSA recovered from selected hospitals in 9 Latin American countries. All isolates were typed by pulsed-field gel electrophoresis (PFGE) and subjected to antibiotic susceptibility testing. Whole-genome sequencing was performed on 96 MRSA representatives. MRSA represented 45% of all (1,185 S. aureus) isolates. The majority of MRSA isolates belonged to clonal cluster (CC) 5. In Colombia and Ecuador, most isolates (?72%) belonged to the USA300-LV lineage (CC8). Phylogenetic reconstructions indicated that MRSA isolates from participating hospitals belonged to three major clades. Clade A grouped isolates with sequence type 5 (ST5), ST105, and ST1011 (mostly staphylococcal chromosomal cassette mec [SCCmec] I and II). Clade B included ST8, ST88, ST97, and ST72 strains (SCCmec IV, subtypes a, b, and c/E), and clade C grouped mostly Argentinian MRSA belonging to ST30. In summary, CC5 MRSA was prevalent in bloodstream infections in LA with the exception of Colombia and Ecuador, where USA300-LV is now the dominant lineage. Clonal replacement appears to be a common phenomenon, and continuous surveillance is crucial to identify changes in the molecular epidemiology of MRSA.
|
|
En línea:
|
http://doi.org/10.1128/AAC.00816-17
|
