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Título:
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Sputum Microscopy With Fluorescein Diacetate Predicts Tuberculosis Infectiousness
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Autores:
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Datta, Sumona ;
Sherman, Jonathan M. ;
Tovar, Marco A. ;
Bravard, Marjory A. ;
Valencia, Teresa ;
Montoya, Rosario ;
Quino, Willi ;
D'Arcy, Nikki ;
Ramos, Eric S. ;
Gilman, Robert H. ;
Evans, Carlton A.
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Tipo de documento:
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texto impreso
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Editorial:
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Oxford University Press, 2019-01-25T16:03:21Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Background: Sputum from patients with tuberculosis contains subpopulations of metabolically active and inactive Mycobacterium tuberculosis with unknown implications for infectiousness. Methods: We assessed sputum microscopy with fluorescein diacetate (FDA, evaluating M. tuberculosis metabolic activity) for predicting infectiousness. Mycobacterium tuberculosis was quantified in pretreatment sputum of patients with pulmonary tuberculosis using FDA microscopy, culture, and acid-fast microscopy. These 35 patients' 209 household contacts were followed with prevalence surveys for tuberculosis disease for 6 years. Results: FDA microscopy was positive for a median of 119 (interquartile range [IQR],
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En línea:
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http://doi.org/10.1093/infdis/jix229
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