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Título:
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The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru
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Autores:
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Grandjean, Louis ;
Iwamoto, Tomotada ;
Lithgow, Anna ;
Gilman, Robert H. ;
Arikawa, Kentaro ;
Nakanishi, Noriko ;
Martin, Laura ;
Castillo, Edith ;
Alarcon, Valentina ;
Coronel, Jorge ;
Solano, Walter ;
Aminian, Minoo ;
Guezala, Claudia ;
Rastogi, Nalin ;
Couvin, David ;
Sheen, Patricia ;
Zimic, Mirko ;
Moore, David A. J.
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Tipo de documento:
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texto impreso
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Editorial:
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Public Library of Science, 2019-02-06T14:53:10Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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BACKGROUND: The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the spread of tuberculosis. METHODS: To investigate the association of Mycobacterium tuberculosis bacterial genotype with drug-resistance. Drug susceptibility testing together with genotyping using both 15-loci MIRU-typing and spoligotyping, was performed on 2,139 culture positive isolates, each from a different patient in Lima, Peru. Demographic, geospatial and socio-economic data were collected using questionnaires, global positioning equipment and the latest national census. RESULTS: The Latin American Mediterranean (LAM) clade (OR 2.4, p
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En línea:
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http://doi.org/10.1371/journal.pone.0126271
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