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McClorry, Shannon ; Zavaleta, Nelly ; Llanos, Alejandro ; Casapía, Martin ; Lönnerdal, Bo ; Slupsky, Carolyn M. | Oxford University Press | 2018-11-08T19:39:20ZBackground Anemia is a term that describes low hemoglobin concentrations and can result from micronutrient deficiencies, infection, or low birth weight. Early-life anemia, particularly iron-deficiency anemia (IDA) is associated with several nega[...]texto impreso
Llanos-Cuentas, Alejandro ; Casapía, Martin ; Chuquiyauri, Raúl ; Hinojosa, Juan-Carlos ; Kerr, Nicola ; Rosario, Maria ; Toovey, Stephen ; Arch, Robert H. ; Phillips, Margaret A. ; Rozenberg, Felix D. ; Bath, Jade ; Ng, Caroline L. ; Cowell, Annie N. ; Winzeler, Elizabeth A. ; Fidock, David A. ; Baker, Mark ; Möhrle, Jörg J. ; Hooft van Huijsduijnen, Rob ; Gobeau, Nathalie ; Araeipour, Nada ; Andenmatten, Nicole ; Rückle, Thomas ; Duparc, Stephan | Elsevier | 2018-11-30T02:09:29ZBACKGROUND: DSM265 is a novel, long-duration inhibitor of plasmodium dihydroorotate dehydrogenase (DHODH) with excellent selectivity over human DHODH and activity against blood and liver stages of Plasmodium falciparum. This study aimed to asses[...]texto impreso
Lacerda, Marcus V. G. ; Llanos-Cuentas, Alejandro ; Krudsood, Srivicha ; Lon, Chanthap ; Saunders, David L. ; Mohammed, Rezika ; Yilma, Daniel ; Batista Pereira, Dhelio ; Espino, Fe E. J. ; Mia, Reginaldo Z. ; Chuquiyauri, Raúl ; Val, Fernando ; Casapía, Martin ; Monteiro, Wuelton M. ; Brito, Marcelo A. M. ; Costa, Monica R. F. ; Buathong, Nillawan ; Noedl, Harald ; Diro, Ermias ; Getie, Sisay ; Wubie, Kalehiwot M. ; Abdissa, Alemseged ; Zeynudin, Ahmed ; Abebe, Cherinet ; Tada, Mauro S. ; Brand, Francoise ; Beck, Hans-Peter ; Angus, Brian ; Duparc, Stephan ; Kleim, Jorg-Peter ; Kellam, Lynda M. ; Rousell, Victoria M. ; Jones, Sion W. ; Hardaker, Elizabeth ; Mohamed, Khadeeja ; Clover, Donna D. ; Fletcher, Kim ; Breton, John J. ; Ugwuegbulam, Cletus O. ; Green, Justin A. ; Koh, Gavin C. K. W. | Massachusetts Medical Society | 2019-07-04T17:00:24ZBACKGROUND: Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed "radical cure"). Tafenoquine is a single-dose 8[...]texto impreso
Llanos-Cuentas, Alejandro ; Lacerda, Marcus V. G. ; Hien, Tran T. ; Velez, Ivan D. ; Namaik-Larp, Chayadol ; Chu, Cindy S. ; Villegas, Maria F. ; Val, Fernando ; Monteiro, Wuelton M. ; Brito, Marcelo A. M. ; Costa, Monica R. F. ; Chuquiyauri, Raúl ; Casapía, Martin ; Nguyen, Chau H. ; Aruachan, Sandra ; Papwijitsil, Ratchadaporn ; Nosten, Francois H. ; Bancone, Germana ; Angus, Brian ; Duparc, Stephan ; Craig, Graham ; Rousell, Victoria M. ; Jones, Sion W. ; Hardaker, Elizabeth ; Clover, Donna D. ; Kendall, Lindsay ; Mohamed, Khadeeja ; Koh, Gavin C. K. W. ; Wilches, Viviana M. ; Breton, John J. ; Green, Justin A. | Massachusetts Medical Society | 2019-07-04T17:01:20ZBACKGROUND: Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. vivax parasitemia and hypnozoites, termed "radical cure." METHODS: We performed a phase 3, pros[...]
