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Arroyo, Gianfranco ; Bustos, Javier A. ; Lescano, Andres G. ; Gonzales, Isidro ; Saavedra, Herbert ; Rodriguez, Silvia ; Pretell, E. Javier ; Bonato, Pierina S. ; Lanchote, Vera L. ; Takayanagui, Osvaldo M. ; Horton, John ; Gonzalez, Armando E. ; Gilman, Robert H. ; Garcia, Hector H. | Oxford University Press | 2019-07-04T16:59:18ZBackground: Albendazole is the drug of choice for the treatment of parenchymal neurocysticercosis, although its efficacy is suboptimal. Plasma levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable amon[...]texto impreso
Arroyo, Gianfranco ; Bustos, Javier A. ; Lescano, Andres G. ; Gonzales, Isidro ; Saavedra, Herbert ; Rodriguez, Silvia ; Pretell, E. Javier ; Bonato, Pierina S. ; Lanchote, Vera L. ; Takayanagui, Osvaldo M. ; Horton, John ; Gonzalez, Armando E. ; Gilman, Robert H. ; Garcia, Hector H. | Oxford University Press | 2019-12-06T21:02:55ZBACKGROUND: The efficacy of albendazole therapy in patients with parenchymal neurocysticercosis (NCC) is suboptimal. Plasma levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable among patients. We hypo[...]texto impreso
Arroyo, Gianfranco ; Rodriguez, Silvia ; Lescano, Andres G. ; Alroy, Karen A. ; Bustos, Javier A. ; Santivañez, Saul ; Gonzales, Isidro ; Saavedra, Herbert ; Pretell, E. Javier ; Gonzalez, Armando E. ; Gilman, Robert H. ; Tsang, Victor C. W. ; Garcia, Hector H. ; Cysticercosis Working Group in Peru | Oxford University Press | 2018-11-30T02:09:29ZBackground: The enzyme-linked immunoelectrotransfer blot (EITB) assay is the reference serological test for neurocysticercosis (NCC). A positive result on EITB does not always correlate with the presence of active infections in the central nervo[...]texto impreso
Garcia, Hector H. ; Gonzalez, Armando E. ; O'Neal, Seth E. ; Gilman, Robert H. | Instituto Nacional de Salud | 2018-11-30T22:50:34ZNeurocysticercosis is the infection of the nervous system by the larvae (cysticerci) of the pork tapeworm Taenia solium. Neurocysticercosis is the major cause of acquired epilepsy worldwide and as such, it represents a global health problem. On [...]texto impreso
Mejia Maza, Alan J. ; Carmen-Orozco, Rogger P. ; Carter, Emma ; Dávila, Danitza G. ; Castillo, Gino ; Morales, Jemina D. ; Mamani, Javier ; Gavidia, Cesar ; Alroy, Joseph ; Sterling, Charles R. ; Gonzalez, Armando E. ; Garcia, Hector H. ; Woltjer, Randy L. ; Verastegui, Manuela R. ; Gilman, Robert H. ; Cysticercosis Working Group in Peru | Wiley | 2018-11-30T02:09:30ZNeurocysticercosis is a parasitic brain disease caused by the larval form (Cysticercus cellulosae) of the Taenia solium and is the leading cause of preventable epilepsy world-wide. However, the pathophysiology and relation to the wide range of c[...]texto impreso
Beam, Michelle ; Spencer, Angela ; Fernandez, Lauralee ; Atto, Ruth ; Muro, Claudio ; Vilchez, Percy ; Gamboa, Ricardo ; Olaya, Sandra ; Ayvar, Viterbo ; Gonzalez, Armando E. ; Garcia, Hector H. ; O'Neal, Seth E. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2018-11-30T02:09:30ZInfection of the brain with Taenia solium larvae (neurocysticercosis) is a leading cause of preventable epilepsy worldwide. Effective and sustainable strategies to control parasite transmission in rural endemic communities are needed to prevent [...]texto impreso
Alroy, Karen A. ; Arroyo, Gianfranco ; Gilman, Robert H. ; Gonzales-Gustavson, Eloy ; Gallegos, Linda ; Gavidia, Cesar M. ; Verastegui, Manuela ; Rodriguez, Silvia ; López, Teresa ; Gomez-Puerta, Luis A. ; Alroy, Joseph ; Garcia, Hector H. ; Gonzalez, Armando E. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2018-11-30T02:09:30ZNeurocysticercosis (NCC), the infection of the human central nervous system (CNS) with larval cysts of Taenia solium causes widespread neurological morbidity. Animal models are crucial for studying the pathophysiology and treatment of NCC. Some [...]texto impreso
Lescano, Andres G. ; Pray, Ian W. ; Gonzalez, Armando E. ; Gilman, Robert H. ; Tsang, Victor C. W. ; Gamboa, Ricardo ; Guezala, M. Claudia ; Aybar, Viterbo ; Rodriguez, Silvia ; Moulton, Lawrence H. ; Leontsini, Elli ; Gonzalvez, Guillermo ; O'Neal, Seth E. ; Garcia, Hector H. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2019-07-04T16:59:24ZThe pork tapeworm, Taenia solium, is among the leading causes of preventable epilepsy in the world and is common in rural areas of developing countries where sanitation is limited and pigs have access to human feces. Prior studies in rural vill[...]texto impreso
Garcia, Hector H. ; Lescano, Andres G. ; Gonzales, Isidro ; Bustos, Javier A. ; Pretell, E. Javier ; Horton, John ; Saavedra, Herbert ; Gonzalez, Armando E. ; Gilman, Robert H. | Oxford University Press | 2019-02-06T14:45:34ZBACKGROUND: The efficacy of current antiparasitic treatment for cerebral Taenia solium cysticercosis with either albendazole (ABZ) or praziquantel (PZQ) is suboptimal. A recent study demonstrated that combining these 2 antiparasitic drugs improv[...]texto impreso
Garcia, Hector H. ; Gonzalez, Armando E. ; Tsang, Victor C. W. ; O'Neal, Seth E. ; Llanos-Zavalaga, Fernando ; Gonzalvez, Guillermo ; Romero, Jaime ; Rodriguez, Silvia ; Moyano, Luz M. ; Ayvar, Viterbo ; Diaz, Andre ; Hightower, Allen ; Craig, Philip S. ; Lightowlers, Marshall W. ; Gauci, Charles G. ; Leontsini, Elli ; Gilman, Robert H. | Massachusetts Medical Society | 2019-02-06T14:45:33ZBACKGROUND: Taeniasis and cysticercosis are major causes of seizures and epilepsy. Infection by the causative parasite Taenia solium requires transmission between humans and pigs. The disease is considered to be eradicable, but data on attempts[...]texto impreso
Vargas-Calla, Ana ; Gomez-Puerta, Luis A. ; Calcina, Juan ; Gonzales-Viera, Omar ; Gavidia, Cesar ; Lopez-Urbina, Maria T. ; Garcia, Hector H. ; Gonzalez, Armando E. | Medknow Publications | 2019-02-06T14:52:14ZOBJECTIVE: To assess the efficacy of triclabendazole (TCBZ) in porcine cysticercosis. METHODS: Eighteen naturally infected cysticercosis pigs were divided into 3 groups of 6 individuals each. The first group was treated orally with TCBZ at a sin[...]texto impreso
Gomez-Puerta, Lucho ; Vargas-Calla, Ana ; Castillo, Yesenia ; Lopez-Urbina, Maria Teresa ; Dorny, Pierre ; Garcia, Hector H. ; Gonzalez, Armando E. ; O'Neal, Seth E. | BMC | 2019-07-04T16:59:33ZBACKGROUND: Taenia solium is an important zoonotic parasite that infects humans as definitive host (taeniasis) and pigs as intermediate host (cysticercosis). Serological diagnosis of porcine cysticercosis is limited to antigen detection using EL[...]texto impreso
Santivanez, Saul J. ; Rodriguez, Mary L. ; Rodriguez, Silvia ; Sako, Yashuito ; Nkouawa, Agathe ; Kobayashi, Yukuharu ; Sotomayor, Alfredo L. ; Peralta, Julio E. ; Valcarcel, Maria ; Gonzalez, Armando E. ; Garcia, Hector H. ; Ito, Akira | American Society for Microbiology | 2019-02-06T14:52:38ZDiagnosis of cystic echinococcosis (CE) is based on the identification of the cyst(s) by imaging, using immunodiagnostic tests mainly as complementary tools in clinical settings. Among the antigens used for immunodiagnosis, previous studies des[...]texto impreso
Marzal, Miguel ; Guerra-Giraldez, Cristina ; Paredes, Adriana ; Cangalaya, Carla ; Rivera, Andrea ; Gonzalez, Armando E. ; Mahanty, Siddhartha ; Garcia, Hector H. ; Nash, Theodore E. | Public Library of Science | 2020-06-10T18:12:17ZCysticidal drug treatment of viable Taenia solium brain parenchymal cysts leads to an acute pericystic host inflammatory response and blood brain barrier breakdown (BBB), commonly resulting in seizures. Naturally infected pigs, untreated or trea[...]texto impreso
Lee, Chan ; Noh, John ; O'Neal, Seth E. ; Gonzalez, Armando E. ; Garcia, Hector H. ; Handali, Sukwan | Public Library of Science | 2019-12-06T21:02:59ZWe developed a novel and portable fluorescent sensor that integrates a lateral flow assay with a quantum dot (Qdots) label and a mobile phone reader for detection of specific antibodies in human serum. We evaluated the utility of this assay to t[...]
