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Llanos-Cuentas, Alejandro ; Casapía, Martin ; Chuquiyauri, Raúl ; Hinojosa, Juan-Carlos ; Kerr, Nicola ; Rosario, Maria ; Toovey, Stephen ; Arch, Robert H. ; Phillips, Margaret A. ; Rozenberg, Felix D. ; Bath, Jade ; Ng, Caroline L. ; Cowell, Annie N. ; Winzeler, Elizabeth A. ; Fidock, David A. ; Baker, Mark ; Möhrle, Jörg J. ; Hooft van Huijsduijnen, Rob ; Gobeau, Nathalie ; Araeipour, Nada ; Andenmatten, Nicole ; Rückle, Thomas ; Duparc, Stephan | Elsevier | 2018-11-30T02:09:29ZBACKGROUND: DSM265 is a novel, long-duration inhibitor of plasmodium dihydroorotate dehydrogenase (DHODH) with excellent selectivity over human DHODH and activity against blood and liver stages of Plasmodium falciparum. This study aimed to asses[...]texto impreso
Moreno, Marta ; Tong-Rios, Carlos ; Orjuela-Sanchez, Pamela ; Carrasco-Escobar, Gabriel ; Campo, Brice ; Gamboa, Dionicia ; Winzeler, Elizabeth A. ; Vinetz, Joseph M. | American Chemical Society | 2018-11-30T02:09:31ZIn vitro culture of Plasmodium vivax liver stages underlies key understandings of the fundamental biology of this parasite, particularly the latent, hyponozoite stage, toward drug and vaccine development. Here, we report systematic production of[...]texto impreso
Orjuela-Sanchez, Pamela ; Villa, Zaira Hellen ; Moreno, Marta ; Tong-Rios, Carlos ; Meister, Stephan ; LaMonte, Gregory M. ; Campo, Brice ; Vinetz, Joseph M. ; Winzeler, Elizabeth A. | American Chemical Society | 2018-11-30T03:10:44ZTo develop new drugs and vaccines for malaria elimination, it will be necessary to discover biological interventions, including small molecules that act against Plasmodium vivax exoerythrocytic forms. However, a robust in vitro culture system fo[...]texto impreso
LaMonte, Gregory M. ; Orjuela-Sanchez, Pamela ; Calla, Jaeson ; Wang, Lawrence T. ; Li, Shangzhong ; Swann, Justine ; Cowell, Annie N. ; Zou, Bing Yu ; Abdel-Haleem Mohamed, Alyaa M. ; Villa Galarce, Zaira Hellen ; Moreno, Marta ; Tong Rios, Carlos ; Vinetz, Joseph M. ; Lewis, Nathan ; Winzeler, Elizabeth A. | Nature Research | 2019-07-04T16:59:30ZThe exoerythrocytic stage of Plasmodium infection is a critical window for prophylactic intervention. Using genome-wide dual RNA sequencing of flow-sorted infected and uninfected hepatoma cells we show that the human mucosal immunity gene, mucin[...]texto impreso
Moreno, Marta ; Tong, Carlos ; Guzman, Mitchel ; Chuquiyauri, Raúl ; Llanos-Cuentas, Alejandro ; Rodriguez, Hugo ; Gamboa, Dionicia ; Meister, Stephan ; Winzeler, Elizabeth A. ; Maguina, Paula ; Conn, Jan E. ; Vinetz, Joseph M. | American Society of Tropical Medicine and Hygiene | 2020-06-10T18:11:37ZAnopheles darlingi Root is the most important malaria vector in the Amazonia region of South America. However, continuous propagation of An. darlingi in the laboratory has been elusive, limiting entomological, genetic/genomic, and vector-pathoge[...]texto impreso
Cowell, Annie N. ; Loy, Dorothy E. ; Sundararaman, Sesh A. ; Valdivia, Hugo ; Fisch, Kathleen ; Lescano, Andres G. ; Baldeviano, G. Christian ; Durand, Salomon ; Gerbasi, Vince ; Sutherland, Colin J. ; Nolder, Debbie ; Vinetz, Joseph M. ; Hahn, Beatrice H. ; Winzeler, Elizabeth A. | American Society of Microbiology | 2019-01-25T16:03:20ZWhole-genome sequencing (WGS) of microbial pathogens from clinical samples is a highly sensitive tool used to gain a deeper understanding of the biology, epidemiology, and drug resistance mechanisms of many infections. However, WGS of organisms [...]texto impreso
Lehmann, Jason S. ; Corey, Victoria C. ; Ricaldi, Jessica N. ; Vinetz, Joseph M. ; Winzeler, Elizabeth A. ; Matthias, Michael A. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:53:42ZLeptospirosis is the most common zoonotic disease worldwide with an estimated 500,000 severe cases reported annually, and case fatality rates of 12-25%, due primarily to acute kidney and lung injuries. Despite its prevalence, the molecular mecha[...]
