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White, Sara E. ; Harvey, Steven A. ; Meza, Graciela ; Llanos, Alejandro ; Guzman, Mitchel ; Gamboa, Dionicia ; Vinetz, Joseph M. | BMC | 2018-11-30T02:09:28ZBACKGROUND: A transmission-blocking vaccine (TBV) to prevent malaria-infected humans from infecting mosquitoes has been increasingly considered as a tool for malaria control and elimination. This study tested the hypothesis that a malaria TBV wo[...]texto impreso
Manrique, Paulo ; Hoshi, Mari ; Fasabi, Manuel ; Nolasco, Oscar ; Yori, Pablo ; Calderon, Martiza ; Gilman, Robert H. ; Kosek, Margaret N. ; Vinetz, Joseph M. ; Gamboa, Dionicia | BMC | 2019-02-06T14:53:06ZBACKGROUND: Several platforms have been used to generate the primary data for microsatellite analysis of malaria parasite genotypes. Each has relative advantages but share a limitation of being time- and cost-intensive. A commercially available [...]texto impreso
Lainhart, William ; Bickersmith, Sara A. ; Moreno, Marta ; Rios, Carlos Tong ; Vinetz, Joseph M. ; Conn, Jan E. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:38ZThe process of colonizing any arthropod species, including vector mosquitoes, necessarily involves adaptation to laboratory conditions. The adaptation and evolution of colonized mosquito populations needs consideration when such colonies are use[...]texto impreso
Agampodi, Suneth B. ; Nugegoda, Dhanaseela B. ; Thevanesam, Vasanthi ; Vinetz, Joseph M. | American Society of Tropical Medicine and Hygiene | 2020-06-10T18:11:35ZTo determine the exposure risk factors of highly endemic rural leptospirosis in tropical setting, we conducted a prospective, hospital-based case control study in Sri Lanka. A conceptual hierarchy of variables was used to analyze the data. Case [...]texto impreso
Agampodi, Suneth B. ; Nugegoda, Dhanaseela B. ; Thevanesam, Vasanthi ; Vinetz, Joseph M. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:40ZTo determine the exposure risk factors of highly endemic rural leptospirosis in tropical setting, we conducted a prospective, hospital-based case control study in Sri Lanka. A conceptual hierarchy of variables was used to analyze the data. Case [...]texto impreso
Llanos-Chea, Fiorella ; Martinez, Dalila ; Rosas, Angel ; Samalvides, Frine ; Vinetz, Joseph M. ; Llanos-Cuentas, Alejandro | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:37ZSevere Plasmodium falciparum malaria is uncommon in South America. Lima, Peru, while not endemic for malaria, is home to specialized centers for infectious diseases that admit and manage patients with severe malaria (SM), all of whom contracted [...]texto impreso
Alnasser, Yossef ; Ferradas, Cusi ; Clark, Taryn ; Calderón, Maritza ; Gurbillon, Alejandro ; Gamboa, Dionicia ; McKakpo, Uri S. ; Quakyi, Isabella A. ; Bosompem, Kwabena M. ; Sullivan, David J. ; Vinetz, Joseph M. ; Gilman, Robert H. | Public Library of Science | 2019-02-06T14:45:09ZPlasmodium vivax is the most prevalent cause of human malaria in the world and can lead to severe disease with high potential for relapse. Its genetic and geographic diversities make it challenging to control. P. vivax is understudied and to ach[...]texto impreso
Moreno, Marta ; Tong-Rios, Carlos ; Orjuela-Sanchez, Pamela ; Carrasco-Escobar, Gabriel ; Campo, Brice ; Gamboa, Dionicia ; Winzeler, Elizabeth A. ; Vinetz, Joseph M. | American Chemical Society | 2018-11-30T02:09:31ZIn vitro culture of Plasmodium vivax liver stages underlies key understandings of the fundamental biology of this parasite, particularly the latent, hyponozoite stage, toward drug and vaccine development. Here, we report systematic production of[...]texto impreso
Orjuela-Sanchez, Pamela ; Villa, Zaira Hellen ; Moreno, Marta ; Tong-Rios, Carlos ; Meister, Stephan ; LaMonte, Gregory M. ; Campo, Brice ; Vinetz, Joseph M. ; Winzeler, Elizabeth A. | American Chemical Society | 2018-11-30T03:10:44ZTo develop new drugs and vaccines for malaria elimination, it will be necessary to discover biological interventions, including small molecules that act against Plasmodium vivax exoerythrocytic forms. However, a robust in vitro culture system fo[...]texto impreso
Felgner, Jiin ; Jain, Aarti ; Nakajima, Rie ; Liang, Li ; Jasinskas, Algis ; Gotuzzo, Eduardo ; Vinetz, Joseph M. ; Miyajima, Fabio ; Pirmohamed, Munir ; Hassan-Hanga, Fatimah ; Umoru, Dominic ; Jibir, Binta Wudil ; Gambo, Safiya ; Olateju, Kudirat ; Felgner, Philip L. ; Obaro, Stephen ; Davies, D. Huw | Public Library of Science | 2019-01-25T15:18:33ZImproved serodiagnostic tests for typhoid fever (TF) are needed for surveillance, to facilitate patient management, curb antibiotic resistance, and inform public health programs. To address this need, IgA, IgM and IgG ELISAs using Salmonella ent[...]texto impreso
LaMonte, Gregory M. ; Orjuela-Sanchez, Pamela ; Calla, Jaeson ; Wang, Lawrence T. ; Li, Shangzhong ; Swann, Justine ; Cowell, Annie N. ; Zou, Bing Yu ; Abdel-Haleem Mohamed, Alyaa M. ; Villa Galarce, Zaira Hellen ; Moreno, Marta ; Tong Rios, Carlos ; Vinetz, Joseph M. ; Lewis, Nathan ; Winzeler, Elizabeth A. | Nature Research | 2019-07-04T16:59:30ZThe exoerythrocytic stage of Plasmodium infection is a critical window for prophylactic intervention. Using genome-wide dual RNA sequencing of flow-sorted infected and uninfected hepatoma cells we show that the human mucosal immunity gene, mucin[...]texto impreso
Barbosa, Susana ; Gozze, Amanda B. ; Lima, Nathalia F. ; Batista, Camilla L. ; Bastos, Melissa da Silva ; Nicolete, Vanessa C. ; Fontoura, Pablo S. ; Goncalves, Raquel M. ; Viana, Susana Ariane S. ; Menezes, Maria Jose ; Scopel, Kezia Katiani G. ; Cavasini, Carlos E. ; Malafronte, Rosely dos Santos ; da Silva-Nunes, Monica ; Vinetz, Joseph M. ; Castro, Marcia C. ; Ferreira, Marcelo U. | Public Library of Science | 2020-06-10T18:12:16ZBACKGROUND: New frontier settlements across the Amazon Basin pose a major challenge for malaria elimination in Brazil. Here we describe the epidemiology of malaria during the early phases of occupation of farming settlements in Remansinho area, [...]texto impreso
Lainhart, William ; Bickersmith, Sara A. ; Nadler, Kyle J. ; Moreno, Marta ; Saavedra, Marlon P. ; Chu, Virginia M. ; Ribolla, Paulo E. ; Vinetz, Joseph M. ; Conn, Jan E. | BMC | 2019-02-06T14:53:06ZBACKGROUND: The major Neotropical malaria vector, Anopheles darlingi, was reintroduced into the Iquitos, Loreto, Peru area during the early 1990s, where it displaced other anophelines and caused a major malaria epidemic. Since then, case numbers[...]texto impreso
Fernandez, Carla ; Lubar, Aristea A. ; Vinetz, Joseph M. ; Matthias, Michael A. | American Society of Tropical Medicine and Hygiene | 2018-11-30T03:10:46ZLeptospira licerasiae serovar Varillal, a group II intermediate pathogen species/serovar discovered in the Peruvian Amazon city of Iquitos, is commonly recognized in this region by sera from humans (at least 40% seroprevalence) without a known c[...]texto impreso
Genetic diversity of Nyssorhynchus (Anopheles) darlingi related to biting behavior in western Amazon
Campos, Melina ; Alonso, Diego Peres ; Conn, Jan E. ; Vinetz, Joseph M. ; Emerson, Kevin J. ; Ribolla, Paulo Eduardo Martins | BMC | 2019-07-04T16:59:36ZBACKGROUND: In the Amazon Basin, Nyssorhynchus (Anopheles) darlingi is the most aggressive and effective malaria vector. In endemic areas, behavioral aspects of anopheline vectors such as host preference, biting time and resting location post b[...]
