Información del autor
Autor Gilman, Robert H. |
Documentos disponibles escritos por este autor (195)
texto impreso
Saunders, Matthew J. ; Tovar, Marco A. ; Collier, Dami ; Baldwin, Matthew R. ; Montoya, Rosario ; Valencia, Teresa R. ; Gilman, Robert H. ; Evans, Carlton A. | Elsevier | 2019-07-04T16:59:18ZBACKGROUND: Active case-finding among contacts of patients with tuberculosis is a global health priority, but the effects of active versus passive case-finding are poorly characterised. We assessed the contribution of active versus passive case-[...]texto impreso
Ruiz-Alejos, Andrea ; Carrillo-Larco, Rodrigo M. ; Miranda, J. Jaime ; Anderson, Cheryl A. M. ; Gilman, Robert H. ; Smeeth, Liam ; Bernabé-Ortiz, Antonio | Nature Research | 2018-11-30T02:09:29ZThe aim of this study was to estimate the incidence of T2DM in three population groups: rural, rural-to-urban migrants and urban dwellers. Data from the PERU MIGRANT Study was analysed. The baseline assessment was conducted in 2007-2008 using a [...]texto impreso
Bazo-Alvarez, Juan Carlos ; Quispe, Renato ; Peralta, Frank ; Poterico, Julio A. ; Valle, Giancarlo A. ; Burroughs, Melissa ; Pillay, Timesh ; Gilman, Robert H. ; Checkley, William ; Malaga, German ; Smeeth, Liam ; Bernabé-Ortiz, Antonio ; Miranda, J. Jaime | Lippincott, Williams & Wilkins | 2019-02-06T14:52:18ZIt is unclear how well currently available risk scores predict cardiovascular disease (CVD) risk in low-income and middle-income countries. We aim to compare the American College of Cardiology/American Heart Association (ACC/AHA) Pooled Cohort r[...]texto impreso
Arroyo, Gianfranco ; Bustos, Javier A. ; Lescano, Andres G. ; Gonzales, Isidro ; Saavedra, Herbert ; Rodriguez, Silvia ; Pretell, E. Javier ; Bonato, Pierina S. ; Lanchote, Vera L. ; Takayanagui, Osvaldo M. ; Horton, John ; Gonzalez, Armando E. ; Gilman, Robert H. ; Garcia, Hector H. | Oxford University Press | 2019-07-04T16:59:18ZBackground: Albendazole is the drug of choice for the treatment of parenchymal neurocysticercosis, although its efficacy is suboptimal. Plasma levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable amon[...]texto impreso
Arroyo, Gianfranco ; Bustos, Javier A. ; Lescano, Andres G. ; Gonzales, Isidro ; Saavedra, Herbert ; Rodriguez, Silvia ; Pretell, E. Javier ; Bonato, Pierina S. ; Lanchote, Vera L. ; Takayanagui, Osvaldo M. ; Horton, John ; Gonzalez, Armando E. ; Gilman, Robert H. ; Garcia, Hector H. | Oxford University Press | 2019-12-06T21:02:55ZBACKGROUND: The efficacy of albendazole therapy in patients with parenchymal neurocysticercosis (NCC) is suboptimal. Plasma levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable among patients. We hypo[...]texto impreso
Bayer, Angela M. ; Danysh, Heather E. ; Garvich, Mijail ; Gonzalvez, Guillermo ; Checkley, William ; Alvarez, Maria ; Gilman, Robert H. | Wiley | 2020-06-10T18:11:35ZDuring the 1997-98 El Nino, Tumbes, Peru received 16 times the annual average rainfall. This study explores how Tumbes residents perceived the impact of the El Nino event on basic necessities, transport, health care, jobs and migration. Forty-fi[...]texto impreso
Arroyo, Gianfranco ; Rodriguez, Silvia ; Lescano, Andres G. ; Alroy, Karen A. ; Bustos, Javier A. ; Santivañez, Saul ; Gonzales, Isidro ; Saavedra, Herbert ; Pretell, E. Javier ; Gonzalez, Armando E. ; Gilman, Robert H. ; Tsang, Victor C. W. ; Garcia, Hector H. ; Cysticercosis Working Group in Peru | Oxford University Press | 2018-11-30T02:09:29ZBackground: The enzyme-linked immunoelectrotransfer blot (EITB) assay is the reference serological test for neurocysticercosis (NCC). A positive result on EITB does not always correlate with the presence of active infections in the central nervo[...]texto impreso
Saavedra-Garcia, Lorena ; Bernabé-Ortiz, Antonio ; Gilman, Robert H. ; Diez-Canseco, Francisco ; Cardenas, Maria Kathia ; Sacksteder, Katherine A. ; Miranda, J. Jaime | Public Library of Science | 2019-02-06T14:53:10ZBACKGROUND: In resourced-constrained settings, daily cooking practices are still the norm. Replacing sodium in regular salt to produce potassium-enriched salts are potential alternative routes to reduce sodium intake, paired with the benefit as[...]texto impreso
Garcia, Hector H. ; Gonzalez, Armando E. ; O'Neal, Seth E. ; Gilman, Robert H. | Instituto Nacional de Salud | 2018-11-30T22:50:34ZNeurocysticercosis is the infection of the nervous system by the larvae (cysticerci) of the pork tapeworm Taenia solium. Neurocysticercosis is the major cause of acquired epilepsy worldwide and as such, it represents a global health problem. On [...]texto impreso
George, Christine Marie ; Sima, Laura ; Arias, M. Helena Jahuira ; Mihalic, Jana ; Cabrera, Lilia Z. ; Danz, David ; Checkley, William ; Gilman, Robert H. | World Health Organization | 2020-06-10T18:11:35ZOBJECTIVE: To assess the extent of arsenic contamination of groundwater and surface water in Peru and, to evaluate the accuracy of the Arsenic Econo-Quick() (EQ) kit for measuring water arsenic concentrations in the field. METHODS: Water sampl[...]texto impreso
Manrique, Paulo ; Hoshi, Mari ; Fasabi, Manuel ; Nolasco, Oscar ; Yori, Pablo ; Calderon, Martiza ; Gilman, Robert H. ; Kosek, Margaret N. ; Vinetz, Joseph M. ; Gamboa, Dionicia | BMC | 2019-02-06T14:53:06ZBACKGROUND: Several platforms have been used to generate the primary data for microsatellite analysis of malaria parasite genotypes. Each has relative advantages but share a limitation of being time- and cost-intensive. A commercially available [...]texto impreso
Taype-Rondan, Álvaro ; Abbs, Elizabeth Sarah ; Lazo-Porras, Maria ; Checkley, William ; Gilman, Robert H. ; Smeeth, Liam ; Miranda, J. Jaime ; Bernabé-Ortiz, Antonio | Springer Verlag | 2019-01-25T15:02:18ZPURPOSE: To evaluate the role of urbanization as an effect modifier for the association between specific chronic conditions and number of conditions with health-related quality of life (QOL). METHODS: We analyzed cross-sectional data from the CR[...]texto impreso
Correa, Malena ; Zimic, Mirko ; Barrientos, Franklin ; Barrientos, Ronald ; Roman-Gonzalez, Avid ; Pajuelo, Monica J. ; Anticona, Cynthia ; Mayta, Holger ; Alva, Alicia ; Solis-Vasquez, Leonardo ; Figueroa, Dante Anibal ; Chavez, Miguel A. ; Lavarello, Roberto ; Castañeda, Benjamin ; Paz-Soldan, Valerie A. ; Checkley, William ; Gilman, Robert H. ; Oberhelman, Richard | Public Library of Science | 2019-03-05T15:23:30ZPneumonia is one of the major causes of child mortality, yet with a timely diagnosis, it is usually curable with antibiotic therapy. In many developing regions, diagnosing pneumonia remains a challenge, due to shortages of medical resources. Lun[...]texto impreso
Mejia Maza, Alan J. ; Carmen-Orozco, Rogger P. ; Carter, Emma ; Dávila, Danitza G. ; Castillo, Gino ; Morales, Jemina D. ; Mamani, Javier ; Gavidia, Cesar ; Alroy, Joseph ; Sterling, Charles R. ; Gonzalez, Armando E. ; Garcia, Hector H. ; Woltjer, Randy L. ; Verastegui, Manuela R. ; Gilman, Robert H. ; Cysticercosis Working Group in Peru | Wiley | 2018-11-30T02:09:30ZNeurocysticercosis is a parasitic brain disease caused by the larval form (Cysticercus cellulosae) of the Taenia solium and is the leading cause of preventable epilepsy world-wide. However, the pathophysiology and relation to the wide range of c[...]texto impreso
Sterling, Robie ; Checkley, William ; Gilman, Robert H. ; Cabrera, Lilia ; Sterling, Charles R. ; Bern, Caryn ; Miranda, J. Jaime | PeerJ | 2020-06-10T18:12:21ZBackground. Longitudinal investigations into the origins of adult essential hypertension have found elevated blood pressure in children to accurately track into adulthood, however the direct causes of essential hypertension in adolescence and ad[...]texto impreso
Montalvo, Raúl ; Bernabé-Ortiz, Antonio ; Kirwan, Daniela E. ; Gilman, Robert H. | African Traditional Herbal Medicine Supporters Initiative | 2018-11-30T02:09:30ZBackground: The changes in body composition markers (weight, fat mass, lean mass, and BMI) over time can be associated with TB treatment outcome among HIV-infected patients. The aim of this study was to investigate whether changes in fat mass an[...]texto impreso
Carmen-Orozco, Rogger P. ; Dávila-Villacorta, Danitza G. ; Cauna, Yudith ; Bernal-Teran, Edson G. ; Bitterfeld, Leandra ; Sutherland, Graham L. ; Chile, Nancy ; Céliz, Rensson H. ; Ferrufino-Schmidt, Maria C. ; Gavidia, Cesar M. ; Sterling, Charles R. ; Garcia, Hector H. ; Gilman, Robert H. ; Verástegui, Manuela Renee | Wiley | 2018-11-30T02:09:30ZNeurocysticercosis (NCC) is a helminth infection affecting the central nervous system caused by the larval stage (cysticercus) of Taenia solium. Since vascular alteration and blood-brain barrier (BBB) disruption contribute to NCC pathology, it i[...]texto impreso
Miranda, J. Jaime ; Bernabé-Ortiz, Antonio ; Diez-Canseco, Francisco ; Malaga, German ; Cárdenas, María K. ; Carrillo-Larco, Rodrigo M. ; Pesantes, M. Amalia ; Araya, Ricardo ; Boggio, Oscar ; Checkley, William ; García, Patricia J. ; Leon-Velarde, Fabiola ; Lescano, Andres G. ; Montori, Victor ; Pan, William ; Rivera-Chira, Maria ; Sacksteder, Katherine ; Smeeth, Liam ; Garcia, Hector H. ; Gilman, Robert H. | Elsevier | 2019-02-06T14:59:06ZThe CRONICAS Centre of Excellence in Chronic Diseases, based at Universidad Peruana Cayetano Heredia, was created in 2009 with support from the U.S. National Heart, Lung, and Blood Institute (NHLBI). The vision of CRONICAS is to build a globally[...]texto impreso
Francis, Elizabeth R. ; Kuo, Chin-Chi ; Bernabé-Ortiz, Antonio ; Nessel, Lisa ; Gilman, Robert H. ; Checkley, William ; Miranda, J. Jaime ; Feldman, Harold I. | BMC | 2019-02-06T14:52:15ZBACKGROUND: The silent progression of chronic kidney diseases (CKD) and its association with other chronic diseases, and high treatment costs make it a great public health concern worldwide. The population burden of CKD in Peru has yet to be fu[...]texto impreso
McAtee, Casey L. ; Webman, Rachel ; Gilman, Robert H. ; Mejia, Carolina ; Bern, Caryn ; Apaza, Sonia ; Espetia, Susan ; Pajuelo, Monica ; Saito, Mayuko ; Challappa, Roxanna ; Soria, Richard ; Ribera, Jose P. ; Lozano, Daniel ; Torrico, Faustino | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:36ZThe effectiveness of rotavirus vaccine in the field may set the stage for a changing landscape of diarrheal illness affecting children worldwide. Norovirus and rotavirus are the two major viral enteropathogens of childhood. This study describes [...]texto impreso
Pham, Luu V. ; Miele, Catherine H. ; Schwartz, Noah G. ; Arias, Rafael S. ; Rattner, Adi ; Gilman, Robert H. ; Miranda, J. Jaime ; Polotsky, Vsevolod Y. ; Checkley, William ; Schwartz, Alan R. | European Respiratory Society | 2019-01-25T15:02:19ZAssociations between sleep disordered breathing (SDB) and cardiometabolic outcomes have not been examined in highlanders.We performed nocturnal polygraphy in Peruvian highlanders (3825 m). Multivariable linear regression models examined associat[...]texto impreso
Alroy, Karen A. ; Arroyo, Gianfranco ; Gilman, Robert H. ; Gonzales-Gustavson, Eloy ; Gallegos, Linda ; Gavidia, Cesar M. ; Verastegui, Manuela ; Rodriguez, Silvia ; López, Teresa ; Gomez-Puerta, Luis A. ; Alroy, Joseph ; Garcia, Hector H. ; Gonzalez, Armando E. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2018-11-30T02:09:30ZNeurocysticercosis (NCC), the infection of the human central nervous system (CNS) with larval cysts of Taenia solium causes widespread neurological morbidity. Animal models are crucial for studying the pathophysiology and treatment of NCC. Some [...]texto impreso
Jennings, Mary Carol ; Tilley, Drake H. ; Ballard, Sarah-Blythe ; Villanueva, Miguel ; Costa, Fernando Maldonado ; López, Martha ; Steinberg, Hannah E. ; Luna, C. Giannina ; Meza, Rina ; Silva, Maria E. ; Gilman, Robert H. ; Simons, Mark P. ; Maves, Ryan C. ; Cabada, Miguel M. | American Society of Tropical Medicine and Hygiene | 2019-01-25T15:02:19ZIn Cusco, Peru, and South America in general, there is a dearth of travelers' diarrhea (TD) data concerning the clinical features associated with enteropathogen-specific infections and destination-specific risk behaviors. Understanding these fac[...]texto impreso
Bui, David P. ; Oren, Eyal ; Roe, Denise J. ; Brown, Heidi E. ; Harris, Robin B. ; Knight, Gwenan M. ; Gilman, Robert H. ; Grandjean, Louis | Oxford University Press | 2018-11-30T02:09:28ZBackground: The majority of tuberculosis transmission occurs in community settings. The primary aim of this study was to assess the association between exposure to community venues and multidrug-resistant tuberculosis (MDR-TB) disease. The secon[...]texto impreso
Zavala-Loayza, J. Alfredo ; Pastorius-Benziger, Catherine ; Cardenas, Maria Kathia ; Carrillo-Larco, Rodrigo M. ; Bernabé-Ortiz, Antonio ; Gilman, Robert H. ; Checkley, William ; Miranda, J. Jaime | Elsevier | 2019-02-06T14:48:08ZBACKGROUND: Over one-quarter of the world's adult population has hypertension, yet achieving adequate treatment or control targets remains a challenge. OBJECTIVE: This study sought to identify, longitudinally, characteristics associated with ant[...]texto impreso
León-Janampa, Nancy ; Liendo, Ruddy ; Gilman, Robert H. ; Padilla, Carlos ; Garcia, Hector H. ; Gonzales, Armando ; Sheen, Patricia ; Pajuelo, Monica J. ; Zimic, Mirko ; Cysticercosis Working Group in Peru | Elsevier | 2019-07-04T16:59:24ZPorcine cysticercosis is an endemic parasitic disease caused by infection with Taenia solium that is found predominantly in developing countries. In order to aid in the development of simple diagnostic approaches, identification and characteriza[...]texto impreso
Burel, Julie G. ; Pomaznoy, Mikhail ; Lindestam Arlehamn, Cecilia S. ; Weiskopf, Daniela ; da Silva Antunes, Ricardo ; Jung, Yunmin ; Babor, Mariana ; Schulten, Veronique ; Seumois, Gregory ; Greenbaum, Jason A. ; Premawansa, Sunil ; Premawansa, Gayani ; Wijewickrama, Ananda ; Vidanagama, Dhammika ; Gunasena, Bandu ; Tippalagama, Rashmi ; deSilva, Aruna D. ; Gilman, Robert H. ; Saito, Mayuko ; Taplitz, Randy ; Ley, Klaus ; Vijayanand, Pandurangan ; Sette, Alessandro ; Peters, Bjoern | eLife Sciences Publications | 2019-07-04T16:59:24ZOur results highlight for the first time that a significant proportion of cell doublets in flow cytometry, previously believed to be the result of technical artifacts and thus ignored in data acquisition and analysis, are the result of biologica[...]texto impreso
Burel, Julie G. ; Pomaznoy, Mikhail ; Lindestam Arlehamn, Cecilia S. ; Weiskopf, Daniela ; da Silva Antunes, Ricardo ; Jung, Yunmin ; Babor, Mariana ; Schulten, Veronique ; Seumois, Gregory ; Greenbaum, Jason A. ; Premawansa, Sunil ; Premawansa, Gayani ; Wijewickrama, Ananda ; Vidanagama, Dhammika ; Gunasena, Bandu ; Tippalagama, Rashmi ; deSilva, Aruna D. ; Gilman, Robert H. ; Saito, Mayuko ; Taplitz, Randy ; Ley, Klaus ; Vijayanand, Pandurangan ; Sette, Alessandro ; Peters, Bjoern | eLife Sciences Publications | 2019-12-06T20:57:41ZOur results highlight for the first time that a significant proportion of cell doublets in flow cytometry, previously believed to be the result of technical artifacts and thus ignored in data acquisition and analysis, are the result of biologica[...]texto impreso
Datta, Sumona ; Sherman, Jonathan M. ; Bravard, Marjory A. ; Valencia, Teresa ; Gilman, Robert H. ; Evans, Carlton A. | Oxford University Press | 2019-02-06T14:52:17ZBACKGROUND: It is difficult to determine whether early tuberculosis treatment is effective in reducing the infectiousness of patients' sputum, because culture takes weeks and conventional acid-fast sputum microscopy and molecular tests cannot d[...]texto impreso
Lescano, Andres G. ; Pray, Ian W. ; Gonzalez, Armando E. ; Gilman, Robert H. ; Tsang, Victor C. W. ; Gamboa, Ricardo ; Guezala, M. Claudia ; Aybar, Viterbo ; Rodriguez, Silvia ; Moulton, Lawrence H. ; Leontsini, Elli ; Gonzalvez, Guillermo ; O'Neal, Seth E. ; Garcia, Hector H. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2019-07-04T16:59:24ZThe pork tapeworm, Taenia solium, is among the leading causes of preventable epilepsy in the world and is common in rural areas of developing countries where sanitation is limited and pigs have access to human feces. Prior studies in rural vill[...]texto impreso
Carrillo-Larco, Rodrigo M. ; Ruiz-Alejos, Andrea ; Bernabé-Ortiz, Antonio ; Gilman, Robert H. ; Smeeth, Liam ; Miranda, J. Jaime | Oxford University Press | 2019-01-25T16:59:36Ztexto impreso
Alnasser, Yossef ; Ferradas, Cusi ; Clark, Taryn ; Calderón, Maritza ; Gurbillon, Alejandro ; Gamboa, Dionicia ; McKakpo, Uri S. ; Quakyi, Isabella A. ; Bosompem, Kwabena M. ; Sullivan, David J. ; Vinetz, Joseph M. ; Gilman, Robert H. | Public Library of Science | 2019-02-06T14:45:09ZPlasmodium vivax is the most prevalent cause of human malaria in the world and can lead to severe disease with high potential for relapse. Its genetic and geographic diversities make it challenging to control. P. vivax is understudied and to ach[...]texto impreso
Tuero, Iskra ; Palma, Sandra ; Cabeza, Franco ; Saleemi, Sarah ; Rodriguez, Silvia ; Gonzales, Isidro ; Mayta, Holger ; Mahanty, Siddhartha ; Garcia, Hector H. ; Gilman, Robert H. | Public Library of Science | 2019-02-06T14:53:09ZBACKGROUND: The ability of Taenia solium to modulate the immune system likely contributes to their longevity in the human host. We tested the hypothesis that the nature of the immune response is related to the location of parasite and clinical m[...]texto impreso
Datta, Sumona ; Shah, Lena ; Gilman, Robert H. ; Evans, Carlton A. | Elsevier | 2019-01-25T15:02:20ZBACKGROUND: The performance of laboratory tests to diagnose pulmonary tuberculosis is dependent on the quality of the sputum sample tested. The relative merits of sputum collection methods to improve tuberculosis diagnosis are poorly characteris[...]texto impreso
Kagning Tsinda, Emmanuel ; Malasao, Rungnapa ; Furuse, Yuki ; Gilman, Robert H. ; Liu, Xiaofang ; Apaza, Sonia ; Espetia, Susan ; Cama, Vitaliano ; Oshitani, Hitoshi ; Saito, Mayuko | American Society of Microbiology | 2019-01-25T15:02:21ZWe report here two complete coding genome sequences of novel genotype GII.8 sapovirus strains identified in diarrhea samples collected from two Peruvian children. The complete coding genome sequences of both GII.8 variants were determined using [...]texto impreso
Tohma, Kentaro ; Saito, Mayuko ; Mayta, Holger ; Zimic, Mirko ; Lepore, Cara J. ; Ford-Siltz, Lauren A. ; Gilman, Robert H. ; Parra, Gabriel I. | American Society of Microbiology | 2018-11-30T02:09:31ZNorovirus, a leading cause of acute gastroenteritis in humans, is a highly diverse virus. Here, we report the complete genome sequence of a nontypeable genogroup II (GII) norovirus that was detected in a symptomatic Peruvian child in 2008. This [...]texto impreso
Proaño, Alvaro ; Xu, Ziyue ; Caligiuri, Philip ; Mollura, Daniel J. ; Gilman, Robert H. | AME Publishing Company | 2019-01-25T16:59:37Ztexto impreso
Bernabé-Ortiz, Antonio ; Carrillo-Larco, Rodrigo M. ; Gilman, Robert H. ; Checkley, William ; Smeeth, Liam ; Miranda, J. Jaime ; CRONICAS Cohort Study Group | BMJ Publishing Group | 2019-02-06T14:52:39ZBACKGROUND: It is important to understand the local burden of non-communicable diseases including within-country heterogeneity. The aim of this study was to characterise hypertension and type-2 diabetes profiles across different Peruvian geogra[...]texto impreso
Oberhelman, Richard A. ; Soto-Castellares, Giselle ; Gilman, Robert H. ; Castillo, Maria E. ; Kolevic, Lenka ; Delpino, Trinidad ; Saito, Mayuko ; Salazar-Lindo, Eduardo ; Negron, Eduardo ; Montenegro, Sonia ; Laguna-Torres, V. Alberto ; Maurtua-Neumann, Paola ; Datta, Sumona ; Evans, Carlton A. | Public Library of Science | 2019-02-06T14:53:11ZBACKGROUND: Diagnosing tuberculosis in children is challenging because specimens are difficult to obtain and contain low tuberculosis concentrations, especially with HIV-coinfection. Few studies included well-controls so test specificities are [...]texto impreso
Grandjean, Louis ; Gilman, Robert H. ; Iwamoto, Tomatada ; Koser, Claudio U. ; Coronel, Jorge ; Zimic, Mirko ; Torok, M. Estee ; Ayabina, Diepreye ; Kendall, Michelle ; Fraser, Christophe ; Harris, Simon ; Parkhill, Julian ; Peacock, Sharon J. ; Moore, David A. J. ; Colijn, Caroline | Public Library of Science | 2019-01-25T15:02:21ZBACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic and preventive strat[...]texto impreso
Mirelman, Andrew J. ; Ballard, Sarah Blythe ; Saito, Mayuko ; Kosek, Margaret N. ; Gilman, Robert H. | Elsevier | 2019-02-06T14:57:43ZBACKGROUND: With candidate norovirus (NV) vaccines in a rapid phase of development, assessment of the potential economic value of vaccine implementation will be necessary to aid health officials in vaccine implementation decisions. To date, no e[...]texto impreso
Lee, Gwenyth O. ; Comina, Germán ; Hernández-Córdova, Gustavo ; Naik, Nehal ; Gayoso, Oscar ; Ticona, Eduardo ; Coronel, Jorge ; Evans, Carlton A. ; Zimic, Mirko ; Paz-Soldan, Valerie A. ; Gilman, Robert H. ; Oberhelman, Richard | Public Library of Science | 2020-07-14T00:02:31ZCough is a characteristic symptom of tuberculosis, is the main cause of transmission, and is used to assess treatment response. We aimed to identify the best measure of cough severity and characterize changes during initial tuberculosis therapy.[...]texto impreso
Proaño, Alvaro ; Bui, David P. ; López, José W. ; Vu, Nancy M. ; Bravard, Marjory A. ; Lee, Gwenyth O. ; Tracey, Brian H. ; Xu, Ziyue ; Comina, Germán ; Ticona, Eduardo ; Mollura, Daniel J. ; Friedland, Jon S. ; Moore, David A. J. ; Evans, Carlton A. ; Caligiuri, Philip ; Gilman, Robert H. | Elsevier | 2018-11-30T03:10:43ZBACKGROUND: Cough frequency, and its duration, is a biomarker that can be used in low-resource settings without the need of laboratory culture and has been associated with transmission and treatment response. Radiologic characteristics associate[...]texto impreso
Pham, Luu V. ; Meinzen, Christopher ; Arias, Rafael S. ; Schwartz, Noah G. ; Rattner, Adi ; Miele, Catherine H. ; Smith, Philip L. ; Schneider, Hartmut ; Miranda, J. Jaime ; Gilman, Robert H. ; Polotsky, Vsevolod Y. ; Checkley, William ; Schwartz, Alan R. | Mary Ann Liebert | 2019-01-25T15:02:22ZPham, Luu V., Christopher Meinzen, Rafael S. Arias, Noah G. Schwartz, Adi Rattner, Catherine H. Miele, Philip L. Smith, Hartmut Schneider, J. Jaime Miranda, Robert H. Gilman, Vsevolod Y. Polotsky, William Checkley, and Alan R. Schwartz. Cross-se[...]texto impreso
Garcia, Hector H. ; Lescano, Andres G. ; Gonzales, Isidro ; Bustos, Javier A. ; Pretell, E. Javier ; Horton, John ; Saavedra, Herbert ; Gonzalez, Armando E. ; Gilman, Robert H. | Oxford University Press | 2019-02-06T14:45:34ZBACKGROUND: The efficacy of current antiparasitic treatment for cerebral Taenia solium cysticercosis with either albendazole (ABZ) or praziquantel (PZQ) is suboptimal. A recent study demonstrated that combining these 2 antiparasitic drugs improv[...]texto impreso
Healy, Katherine ; Labrique, Alain B. ; Miranda, J. Jaime ; Gilman, Robert H. ; Danz, David ; Davila-Roman, Victor G. ; Huicho, Luis ; Leon-Velarde, Fabiola ; Checkley, William | Mary Ann Liebert | 2019-02-06T14:45:35ZHealy, Katherine, Alain B. Labrique, J. Jaime Miranda, Robert H. Gilman, David Danz, Victor G. Davila-Roman, Luis Huicho, Fabiola Leon-Velarde, and William Checkley. Dark adaptation at high altitude: an unexpected pupillary response to chronic h[...]texto impreso
Pajuelo, Monica J. ; Anticona Huaynate, Cynthia ; Correa, Malena ; Mayta Malpartida, Holger ; Ramal Asayag, Cesar ; Seminario, Juan R. ; Gilman, Robert H. ; Murphy, Laura ; Oberhelman, Richard A. ; Paz-Soldan, Valerie A. | BMC | 2018-11-30T03:10:43ZBACKGROUND: Delays in receiving adequate care for children suffering from pneumonia can be life threatening and have been described associated with parents' limited education and their difficulties in recognizing the severity of the illness. The[...]texto impreso
Ruiz-Grosso, Paulo ; Bernabé-Ortiz, Antonio ; Diez-Canseco, Francisco ; Gilman, Robert H. ; Checkley, William ; Bennett, Ian M. ; Miranda, J. Jaime | Springer | 2019-02-06T14:52:39ZIn low- and middle-income countries, migration to urban settings has reshaped the sprawl and socio demographic profiles of major cities. Depressive episodes make up a large portion of the burden of disease worldwide and are related to socio-demo[...]texto impreso
Wingfield, Tom ; Boccia, Delia ; Tovar, Marco A. ; Huff, Doug ; Montoya, Rosario ; Lewis, James J. ; Gilman, Robert H. ; Evans, Carlton A. | BMC | 2019-02-06T14:52:15ZBackground. Cash transfers are key interventions in the World Health Organisation’s post-2015 global TB policy. However, evidence guiding TB-specific cash transfer implementation is limited. We designed, implemented and refined a novel TB-specif[...]texto impreso
Dudley, Matthew Z. ; Sheen, Patricia ; Gilman, Robert H. ; Ticona, Eduardo ; Friedland, Jon S. ; Kirwan, Daniela E. ; Caviedes, Luz ; Rodriguez, Richard ; Cabrera, Lilia Z. ; Coronel, Jorge ; Grandjean, Louis ; Moore, David A. J. ; Evans, Carlton A. ; Huaroto, Luz ; Chavez-Perez, Victor ; Zimic, Mirko | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:12ZHospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA[...]texto impreso
Vargas-Cuentas, Natalia I. ; Roman-Gonzalez, Avid ; Gilman, Robert H. ; Barrientos, Franklin ; Ting, James ; Hidalgo, Daniela ; Jensen, Kelly ; Zimic, Mirko | Public Library of Science | 2019-01-25T15:18:33ZBACKGROUND: Autism spectrum disorder (ASD) currently affects nearly 1 in 160 children worldwide. In over two-thirds of evaluations, no validated diagnostics are used and gold standard diagnostic tools are used in less than 5% of evaluations. Cur[...]texto impreso
Jara, Luis M. ; Rodriguez, Magaly ; Altamirano, Faride ; Herrera, Antonio ; Verastegui, Manuela ; Gimenez-Lirola, Luis G. ; Gilman, Robert H. ; Gavidia, Cesar M. | American Society of Tropical Medicine and Hygiene | 2019-07-04T16:59:29ZCystic echinococcosis (CE) is a parasitic zoonosis caused by the larval stage of the tapeworm Echinococcus granulosus. Detection of the adult stage in the canine definitive host is essential for estimating infection rates, surveillance and monit[...]texto impreso
Bernabé-Ortiz, Antonio ; Smeeth, Liam ; Gilman, Robert H. ; Sanchez-Abanto, Jose R. ; Checkley, William ; Miranda, J. Jaime ; CRONICAS Cohort Study Group | Hindawi Publishing Corporation | 2019-02-06T14:45:11ZObjective. To develop and validate a risk score for detecting cases of undiagnosed diabetes in a resource-constrained country. Methods. Two population-based studies in Peruvian population aged > /=35 years were used in the analysis: the ENINBSC [...]texto impreso
Gutierrez-Loli, Renzo ; Ferradas, Cusi ; Diestra, Andrea ; Traianou, Aliki ; Bowman, Natalie ; Bok, Jeroen ; Reimer-McAtee, Melissa ; Ramal, Cesar ; Ticona, Eduardo ; Steinberg, Hannah ; Mayta, Holger ; Calderón, Maritza ; Calla-Choque, Jaeson S. ; Sterling, Charles ; Gilman, Robert H. ; Toxoplasmosis Working Group in Peru and Bolivia | American Society of Tropical Medicine and Hygiene | 2019-07-04T16:59:29ZQuantitative polymerase chain reaction (qPCR) for Toxoplasma gondii multicopy genes has emerged as a promising strategy for sensitive detection of parasite DNA. qPCR can be performed from blood samples, which are minimally invasive to collect. H[...]texto impreso
Lazo, Maria de los Angeles ; Bernabé-Ortiz, Antonio ; Pinto, Miguel E. ; Ticse, Ray ; Malaga, German ; Sacksteder, Katherine ; Miranda, J. Jaime ; Gilman, Robert H. | Public Library of Science | 2020-06-10T18:12:17ZAIM: We aimed to estimate the morbidity rate and associated factors for diabetic peripheral neuropathy (DPN) in a low-middle income country setting. METHODS: Cross-sectional study, data was gathered at Peru's Ministry of Health national special[...]texto impreso
Alcántara, Roberto ; Fuentes, Patricia ; Marin, Lisette ; Kirwan, Daniela E. ; Gilman, Robert H. ; Zimic, Mirko ; Sheen, Patricia | American Society for Microbiology | 2020-07-14T00:00:54ZPyrazinamide (PZA) is considered the pivot drug in all tuberculosis treatment regimens, due to its particular action on the persistent forms of Mycobacterium tuberculosis. However, no drug susceptibility test (DST) is considered sufficiently rel[...]texto impreso
McCloskey, Morgan L. ; Tarazona-Meza, Carla E. ; Jones-Smith, Jessica C. ; Miele, Catherine H. ; Gilman, Robert H. ; Bernabé-Ortiz, Antonio ; Miranda, J. Jaime ; Checkley, William | BMC | 2019-01-25T15:18:33ZBACKGROUND: Diet and activity are thought to worsen with urbanization, thereby increasing risk of obesity and chronic diseases. A better understanding of dietary and activity patterns across the urbanization divide may help identify pathways, an[...]texto impreso
Quispe, Renato ; Bazo-Alvarez, Juan Carlos ; Burroughs Pena, Melissa S. ; Poterico, Julio A. ; Gilman, Robert H. ; Checkley, William ; Bernabé-Ortiz, Antonio ; Huffman, Mark D. ; Miranda, J. Jaime | Wiley Open Access | 2019-02-06T14:52:41ZBACKGROUND: Short-term risk assessment tools for prediction of cardiovascular disease events are widely recommended in clinical practice and are used largely for single time-point estimations; however, persons with low predicted short-term risk [...]texto impreso
Yauri, Veronica ; Castro-Sesquen, Yagahira E. ; Verastegui, Manuela ; Angulo, Noelia ; Recuenco, Fernando ; Cabello, Ines ; Malaga, Edith ; Bern, Caryn ; Gavidia, Cesar M. ; Gilman, Robert H. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:48:08ZPigs were infected with a Bolivian strain of Trypanosoma cruzi (genotype I) and evaluated up to 150 days postinoculation (dpi) to determine the use of pigs as an animal model of Chagas disease. Parasitemia was observed in the infected pigs durin[...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; López, José W. ; Lee, Gwenyth O. ; Bui, David ; Datta, Sumona ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Caviedes, Luz ; Cabrera, Jose L. ; Salas, Antonio ; Ticona, Eduardo ; Vu, Nancy M. ; Kirwan, Daniela E. ; Loader, Maria-Cristina I. ; Friedland, Jon S. ; Moore, David A. J. ; Evans, Carlton A. ; Tracey, Brian H. ; Gilman, Robert H. | Oxford University Press | 2019-01-25T16:59:37ZBackground: Cough is the major determinant of tuberculosis transmission. Despite this, there is a paucity of information regarding characteristics of cough frequency throughout the day and in response to tuberculosis therapy. Here we evaluate th[...]texto impreso
Pirini, Francesca ; Noazin, Sassan ; Jahuira-Arias, Martha H. ; Rodriguez-Torres, Sebastian ; Friess, Leah ; Michailidi, Christina ; Cok, Jaime ; Combe, Juan ; Vargas, Gloria ; Prado, William ; Soudry, Ethan ; Perez, Jimena ; Yudin, Tikki ; Mancinelli, Andrea ; Unger, Helen ; Ili-Gangas, Carmen ; Brebi-Mieville, Priscilla ; Berg, Douglas E. ; Hayashi, Masamichi ; Sidransky, David ; Gilman, Robert H. ; Guerrero-Preston, Rafael | Impact journals | 2019-01-25T15:18:34ZClinically useful molecular tools to triage gastric cancer patients are not currently available. We aimed to develop a molecular tool to predict gastric cancer risk in endoscopy-driven biopsies obtained from high-risk gastric cancer clinics in l[...]texto impreso
Bernabé-Ortiz, Antonio ; Sal Y Rosas, Víctor G. ; Ponce-Lucero, Vilarmina ; Cárdenas, María K. ; Carrillo-Larco, Rodrigo M. ; Diez-Canseco, Francisco ; Pesantes, M. Amalia ; Sacksteder, Katherine A. ; Gilman, Robert H. ; Miranda, J. Jaime | Nature Research | 2020-07-14T00:00:57ZReplacement of regular salt with potassium-enriched substitutes reduces blood pressure in controlled situations, mainly among people with hypertension. We report on a population-wide implementation of this strategy in a stepped-wedge cluster ran[...]texto impreso
Garcia, Hector H. ; Gonzalez, Armando E. ; Tsang, Victor C. W. ; O'Neal, Seth E. ; Llanos-Zavalaga, Fernando ; Gonzalvez, Guillermo ; Romero, Jaime ; Rodriguez, Silvia ; Moyano, Luz M. ; Ayvar, Viterbo ; Diaz, Andre ; Hightower, Allen ; Craig, Philip S. ; Lightowlers, Marshall W. ; Gauci, Charles G. ; Leontsini, Elli ; Gilman, Robert H. | Massachusetts Medical Society | 2019-02-06T14:45:33ZBACKGROUND: Taeniasis and cysticercosis are major causes of seizures and epilepsy. Infection by the causative parasite Taenia solium requires transmission between humans and pigs. The disease is considered to be eradicable, but data on attempts[...]texto impreso
Garcia, Hector H. ; O'Neal, Seth E. ; Gilman, Robert H. | Massachusetts Medical Society | 2019-02-22T14:55:49Ztexto impreso
Miele, Catherine H. ; Grigsby, Matthew R. ; Siddharthan, Trishul ; Gilman, Robert H. ; Miranda, J. Jaime ; Bernabé-Ortiz, Antonio ; Wise, Robert A. ; Checkley, William | BMJ Publishing Group | 2018-11-30T03:10:45ZBACKGROUND: Chronic lung disease is a leading contributor to the global disease burden; however, beyond tobacco smoke, we do not fully understand what risk factors contribute to lung function decline in low-income and middle-income countries. ME[...]texto impreso
Ballard, Sarah-Blythe ; Reaves, Erik J. ; Luna, C. Giannina ; Silva, Maria E. ; Rocha, Claudio ; Heitzinger, Kristen ; Saito, Mayuko ; Apaza, Sonia ; Espetia, Susan ; Blazes, David L. ; Tilley, Drake H. ; Guzman Aguilar, Rene C. ; Gilman, Robert H. ; Bausch, Daniel G. | Public Library of Science | 2019-02-06T14:53:10ZBACKGROUND: Successful vaccination strategies against norovirus will require understanding the burden of disease and relevant genotypes in populations. However, few data are available from cohort studies of adults living in low- and middle-inco[...]texto impreso
Sánchez, Gerardo J. ; Mayta, Holger ; Pajuelo, Monica J. ; Neira, Karen ; Xiaofang, Liu ; Cabrera, Lilia ; Ballard, Sarah Blythe ; Crabtree, Jean E. ; Kelleher, Dermot ; Cama, Vitaliano ; Bern, Caryn ; Oshitani, Hitoshi ; Gilman, Robert H. ; Saito, Mayuko ; Sapovirus Working Group | Oxford University Press | 2018-11-30T03:10:45ZBackground: Sapovirus is one of the primary viral causes of acute gastroenteritis (AGE), especially where rotavirus vaccination has been implemented. The characteristics and impact of natural infection at the community level, however, have not b[...]texto impreso
Liu, Xiaofang ; Jahuira, Helena ; Gilman, Robert H. ; Alva, Alicia ; Cabrera, Lilia ; Okamoto, Michiko ; Xu, Hang ; Windle, Henry J. ; Kelleher, Dermot ; Varela, Marco ; Verastegui, Manuela ; Calderón, Maritza ; Sanchez, Gerardo ; Sarabia, Vanessa ; Ballard, Sarah B. ; Bern, Caryn ; Mayta, Holger ; Crabtree, Jean E. ; Cama, Vitaliano ; Saito, Mayuko ; Oshitani, Hitoshi | American Society for Microbiology | 2019-02-06T14:45:36ZHuman sapovirus has been shown to be one of the most important etiologies in pediatric patients with acute diarrhea. However, very limited data are available about the causative roles and epidemiology of sapovirus in community settings. A nest[...]texto impreso
Solis, Leonardo ; Coronel, Jorge ; Rueda, Daniel ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Elsevier | 2019-02-06T14:57:42ZTuberculosis (TB) control efforts are hampered by a mismatch in diagnostic technology. Lack of adequate early diagnostics and Multi-drug resistant (MDR) detection is a critical problem in control efforts. Alternate and novel diagnostic approache[...]texto impreso
Lora, Meredith H. ; Reimer-McAtee, Melissa J. ; Gilman, Robert H. ; Lozano, Daniel ; Saravia, Ruth ; Pajuelo, Monica ; Bern, Caryn ; Castro, Rosario ; Espinoza, Magaly ; Vallejo, Maya ; Solano, Marco ; Challapa, Roxana ; Torrico, Faustino | BMC | 2019-02-06T14:52:14ZBackground. Myrciaria dubia is an Amazonian fruit shrub that produces numerous bioactive phytochemicals, but is best known by its high L-ascorbic acid (AsA) content in fruits. Pronounced variation in AsA content has been observed both within and[...]texto impreso
Schiaffino, Francesca ; Lee, Gwenyth O. ; Paredes-Olortegui, Maribel ; Cabrera, Lilia ; Penataro-Yori, Pablo ; Gilman, Robert H. ; Kosek, Margaret N. | Thieme Open | 2019-03-05T15:23:25ZBACKGROUND: Bacillus Calmette-Guerin (BCG) scar formation is considered a visual marker of vaccination and cell-mediated immune response. This study characterized the association between pregnancy and birth characteristics with BCG scar formati[...]texto impreso
Schiaffino, Francesca ; Lee, Gwenyth O. ; Paredes-Olortegui, Maribel ; Cabrera, Lilia ; Penataro-Yori, Pablo ; Gilman, Robert H. ; Kosek, Margaret N. | Thieme Publishing | 2019-12-06T21:03:00ZBACKGROUND: Bacillus Calmette-Guerin (BCG) scar formation is considered a visual marker of vaccination and cell-mediated immune response. This study characterized the association between pregnancy and birth characteristics with BCG scar formati[...]texto impreso
López, José W. ; Loader, Maria-Cristina I. ; Smith, Daniel ; Pastorius, Daniel ; Bravard, Marjory ; Caviedes, Luz ; Romero, Karina M. ; Clark, Taryn ; Checkley, William ; Ticona, Eduardo ; Friedland, Jon S. ; Gilman, Robert H. | American Society of Tropical Medicine and Hygiene | 2018-11-30T03:10:46ZTo reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an eas[...]texto impreso
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Bayer, Angela M. ; Cabrera, Lilia Z. ; Gilman, Robert H. ; Hindin, Michelle J. ; Tsui, Amy O. | Elsevier | 2020-06-10T18:11:36ZWe analyzed the association between sub-scales developed with adolescents and the outcomes of precoital behaviors and vaginal sex in Lima, Peru. Adolescent participants in key informant sessions operationalized concepts identified during qualita[...]texto impreso
Martin, Laura ; Coronel, Jorge ; Faulx, Dunia ; Valdez, Melissa ; Metzler, Mutsumi ; Crudder, Chris ; Castillo, Edith ; Caviedes, Luz ; Grandjean, Louis ; Rodriguez, Mitzi ; Friedland, Jon S. ; Gilman, Robert H. ; Moore, David A. J. | Public Library of Science | 2020-06-10T18:12:20ZBACKGROUND: Even though the WHO-endorsed, non-commercial MODS assay offers rapid, reliable TB liquid culture and phenotypic drug susceptibility testing (DST) at lower cost than any other diagnostic, uptake has been patchy. In part this reflects [...]texto impreso
Shah, Vishal ; Ferrufino, Lisbeth ; Gilman, Robert H. ; Ramirez, Margot ; Saenza, Eliana ; Malaga, Edith ; Sanchez, Gerardo ; Okamoto, Emi E. ; Sherbuck, Jacqueline E. ; Clark, Eva H. ; Galdos-Cardenas, Gerson ; Bozo, Ricardo ; Flores-Franco, Jorge Luis ; Colanzi, Rony ; Verastegui, Manuela ; Bern, Caryn | American Society for Microbiology | 2020-06-10T18:11:30ZTrypanosoma cruzi causes Chagas disease, which affects an estimated 7 million to 8 million people. Chagas disease is endemic throughout Latin America, with the highest prevalence in Bolivia. Conventional diagnosis requires a well-equipped labor[...]texto impreso
Bustos, Javier A. ; Arroyo, Gianfranco ; Gilman, Robert H. ; Soto-Becerra, Percy ; Gonzales, Isidro ; Saavedra, Herbert ; Pretell, E. Javier ; Nash, Theodore E. ; O'Neal, Seth E. ; Del Brutto, Oscar H. ; Gonzalez, Armando E. ; Garcia, Hector H. ; Cysticercosis Working Group in Peru | Oxford University Press | 2020-07-14T00:00:59ZBACKGROUND: Neurocysticercosis (NCC) is a major cause of acquired epilepsy in most of the world. Larval cysts in the human brain eventually resolve and either disappear or leave a calcified scar that is associated with seizures. This study asses[...]texto impreso
Pajuelo, Monica J. ; Eguiluz, María ; Roncal, Elisa ; Quiñones-García, Stefany ; Clipman, Steven J. ; Calcina, Juan ; Gavidia, Cesar M. ; Sheen, Patricia ; Garcia, Hector H. ; Gilman, Robert H. ; Gonzalez, Armando E. ; Zimic, Mirko ; Cysticercosis Working Group in Peru | Public Library of Science | 2019-01-25T15:18:36ZThe adult Taenia solium, the pork tapeworm, usually lives as a single worm in the small intestine of humans, its only known definitive host. Mechanisms of genetic variation in T. solium are poorly understood. Using three microsatellite markers p[...]texto impreso
Chuquiyauri, Raúl ; Molina, Douglas M. ; Moss, Eli L. ; Wang, Ruobing ; Gardner, Malcolm J. ; Brouwer, Kimberly C. ; Torres, Sonia ; Gilman, Robert H. ; Llanos-Cuentas, Alejandro ; Neafsey, Daniel E. ; Felgner, Philip ; Liang, Xiaowu ; Vinetz, Joseph M. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:38ZLarge scale antibody responses in Plasmodium vivax malaria remains unexplored in the endemic setting. Protein microarray analysis of asexual-stage P. vivax was used to identify antigens recognized in sera from residents of hypoendemic Peruvian [...]texto impreso
Bernabé-Ortiz, Antonio ; Carrillo-Larco, Rodrigo M. ; Gilman, Robert H. ; Miele, Catherine H. ; Checkley, William ; Wells, Jonathan C. ; Smeeth, Liam ; Miranda, J. Jaime | Elsevier | 2019-02-06T14:45:10ZBACKGROUND: The study aims were to estimate the incidence and risk factors for T2D in four settings with different degree of urbanization and altitude in Peru. METHODS: Prospective cohort study conducted in urban, semi-urban, and rural areas in[...]texto impreso
Moyano, Luz M. ; O'Neal, Seth E. ; Ayvar, Viterbo ; Gonzalvez, Guillermo ; Gamboa, Ricardo ; Vilchez, Percy ; Rodriguez, Silvia ; Reistetter, Joe ; Tsang, Victor C. W. ; Gilman, Robert H. ; Gonzalez, Armando E. ; Garcia, Hector H. | Public Library of Science | 2019-02-06T14:45:56ZBACKGROUND: Neurocysticercosis is a common helminthic infection of the central nervous system and an important cause of adult-onset epilepsy in endemic countries. However, few studies have examined associations between neurologic symptoms, serol[...]texto impreso
Waltmann, Andreea ; Willcox, Alexandra C. ; Balasubramanian, Sujata ; Borrini Mayori, Katty ; Mendoza Guerrero, Sandra ; Salazar Sanchez, Renzo S. ; Roach, Jeffrey ; Condori Pino, Carlos ; Gilman, Robert H. ; Bern, Caryn ; Juliano, Jonathan J. ; Levy, Michael Z. ; Meshnick, Steven R. ; Bowman, Natalie M. | Public Library of Science | 2019-07-04T17:00:15ZTriatomine vectors transmit Trypanosoma cruzi, the etiological agent of Chagas disease in humans. Transmission to humans typically occurs when contaminated triatomine feces come in contact with the bite site or mucosal membranes. In the Souther[...]texto impreso
Kirwan, Daniela E. ; Ugarte-Gil, Cesar ; Gilman, Robert H. ; Hasan Rizvi, Syed M. ; Cerrillo, Gustavo ; Cok, Jaime ; Ticona, Eduardo ; Cabrera, Jose Luis ; Matos, Eduardo D. ; Evans, Carlton A. ; Moore, David A. J. ; Friedland, Jon S. ; Lymph Node Tuberculosis Working Group | American Society of Tropical Medicine and Hygiene | 2019-01-25T15:18:36ZThe differential diagnosis for lymphadenopathy is wide and clinical presentations overlap, making obtaining an accurate diagnosis challenging. We sought to characterize the clinical and radiological characteristics, histological findings, and di[...]texto impreso
Rothstein, Jessica D. ; Mendoza, Alejandra Llican ; Cabrera, Lilia Z. ; Pachas, Jessica ; Calderón, Maritza ; Pajuelo, Monica J. ; Caulfield, Laura E. ; Winch, Peter J. ; Gilman, Robert H. | American Society of Tropical Medicine and Hygiene | 2019-07-04T17:00:16ZFeeding of infant formula using contaminated bottles may be an important transmission pathway of enteric pathogens during early life. Determinants of suboptimal bottle hygiene and the feasibility and acceptability of intervention strategies have[...]texto impreso
Pajuelo, Monica J. ; Eguiluz, María ; Dahlstrom, Eric ; Requena, David ; Guzman, Frank ; Ramírez, Manuel ; Sheen, Patricia ; Frace, Michael ; Sammons, Scott ; Cama, Vitaliano ; Anzick, Sarah ; Bruno, Dan ; Mahanty, Siddhartha ; Wilkins, Patricia ; Nash, Theodore ; Gonzalez, Armando ; Garcia, Hector H. ; Gilman, Robert H. ; Porcella, Steve ; Zimic, Mirko | Public Library of Science | 2019-02-06T14:53:08ZBACKGROUND: Infections with Taenia solium are the most common cause of adult acquired seizures worldwide, and are the leading cause of epilepsy in developing countries. A better understanding of the genetic diversity of T. solium will improve p[...]texto impreso
Ticona, Eduardo ; Huaroto, Luz ; Kirwan, Daniela E. ; Chumpitaz, Milagros ; Munayco, Cesar V. ; Maguina, Monica ; Tovar, Marco A. ; Evans, Carlton A. ; Escombe, Roderick ; Gilman, Robert H. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:48:07ZMultidrug-resistant tuberculosis (MDRTB) rates in a human immunodeficiency virus (HIV) care facility increased by the year 2000-56% of TB cases, eight times the national MDRTB rate. We reported the effect of tuberculosis infection control measu[...]texto impreso
Bernabé-Ortiz, Antonio ; Carrillo-Larco, Rodrigo M. ; Gilman, Robert H. ; Checkley, William ; Smeeth, Liam ; Miranda, J. Jaime | BMJ Publishing Group | 2019-01-25T15:18:37ZBACKGROUND: Most of the data regarding the burden of hypertension in low-income and middle-income countries comes from cross-sectional surveys instead of longitudinal studies. We estimated the incidence of, and risk factors for, hypertension in [...]texto impreso
Lazo-Porras, Maria ; Bernabé-Ortiz, Antonio ; Sacksteder, Katherine A. ; Gilman, Robert H. ; Malaga, German ; Armstrong, David G. ; Miranda, J. Jaime | BMC | 2019-02-06T14:51:21ZBACKGROUND: Diabetic foot neuropathy (DFN) is one of the most important complications of diabetes mellitus; its early diagnosis and intervention can prevent foot ulcers and the need for amputation. Thermometry, measuring the temperature of the f[...]texto impreso
Mayta, Holger ; Romero, Yomara K. ; Pando, Alejandra ; Verastegui, Manuela ; Tinajeros, Freddy ; Bozo, Ricardo ; Henderson-Frost, Josephine ; Colanzi, Rony ; Flores, Jorge ; Lerner, Richard ; Bern, Caryn ; Gilman, Robert H. | Public Library of Science | 2019-07-04T17:00:16ZBACKGROUND: The detection of Trypanosoma cruzi genetic material in clinical samples is considered an important diagnostic tool for Chagas disease. We have previously demonstrated that PCR using clot samples yields greater sensitivity than either[...]texto impreso
Palma, Sandra ; Chile, Nancy ; Carmen-Orozco, Rogger P. ; Trompeter, Grace ; Fishbeck, Kayla ; Cooper, Virginia ; Rapoport, Laura ; Bernal-Teran, Edson G. ; Condori, Beth J. ; Gilman, Robert H. ; Verastegui, Manuela R. | Public Library of Science | 2019-07-04T17:00:16ZTaenia solium is known to cause human cysticercosis while T. saginata does not. Comparative in vitro and in vivo studies on the oncosphere and the postoncospheral (PO) forms of T. solium and T. saginata may help to elucidate why cysticercosis ca[...]texto impreso
Chile, Nancy ; Clark, Taryn ; Arana, Yanina ; Ortega, Ynes R. ; Palma, Sandra ; Mejia, Alan ; Angulo, Noelia ; Kosek, Jon C. ; Kosek, Margaret ; Gomez-Puerta, Luis A. ; Garcia, Hector H. ; Gavidia, Cesar M. ; Gilman, Robert H. ; Verastegui, Manuela | Public Library of Science | 2019-02-06T14:45:12ZBACKGROUND: The transitional period between the oncosphere and the cysticercus of Taenia solium is the postoncospheral (PO) form, which has not yet been completely characterized. The aim of this work was to standardize a method to obtain T. soli[...]texto impreso
Miele, Catherine H. ; Schwartz, Alan R. ; Gilman, Robert H. ; Pham, Luu ; Wise, Robert A. ; Davila-Roman, Victor G. ; Jun, Jonathan C. ; Polotsky, Vsevolod Y. ; Miranda, J. Jaime ; Leon-Velarde, Fabiola ; Checkley, William | Mary Ann Liebert | 2019-02-06T14:45:56ZMiele, Catherine H., Alan R. Schwartz, Robert H. Gilman, Luu Pham, Robert A. Wise, Victor G. Davila-Roman, Jonathan C. Jun, Vsevolod Y. Polotsky, J. Jaime Miranda, Fabiola Leon-Velarde, and William Checkley. Increased cardiometabolic risk and wo[...]texto impreso
Kephart, Josiah L. ; Fandiño-Del-Rio, Magdalena ; Koehler, Kirsten ; Bernabé-Ortiz, Antonio ; Miranda, J. Jaime ; Gilman, Robert H. ; Checkley, William | BMC | 2020-07-14T00:02:29ZBACKGROUND: Indoor air pollution is an important risk factor for health in low- and middle-income countries. METHODS: We measured indoor fine particulate matter (PM2.5) and carbon monoxide (CO) concentrations in 617 houses across four settings w[...]texto impreso
Pehrsson, Erica C. ; Tsukayama, Pablo ; Patel, Sanket ; Mejia-Bautista, Melissa ; Sosa-Soto, Giordano ; Navarrete, Karla M. ; Calderón, Maritza ; Cabrera, Lilia ; Hoyos-Arango, William ; Bertoli, M. Teresita ; Berg, Douglas E. ; Gilman, Robert H. ; Dantas, Gautam | Nature Research | 2019-02-06T14:45:57ZAntibiotic-resistant infections annually claim hundreds of thousands of lives worldwide. This problem is exacerbated by exchange of resistance genes between pathogens and benign microbes from diverse habitats. Mapping resistance gene disseminati[...]texto impreso
Oberhelman, Richard A. ; Huaynate, Cynthia Anticona ; Correa, Malena ; Malpartida, Holger Mayta ; Pajuelo, Monica ; Paz-Soldan, Valerie A. ; Gilman, Robert H. ; Zimic, Mirko ; Murphy, Laura ; Belizan, Jose | American Society of Tropical Medicine and Hygiene | 2019-01-25T17:00:25ZPostdoctoral training programs are usually highly individualized arrangements between trainees and a limited number of senior mentors in their field, an approach that contrasts with current trends in public health education that promote interdis[...]texto impreso
Caravedo, Maria A. ; Painschab, Matthew S. ; Davila-Roman, Victor G. ; de Ferrari, Aldo ; Gilman, Robert H. ; Vasquez-Villar, Angel D. ; Pollard, Suzanne L. ; Miranda, J. Jaime ; Checkley, William | Elsevier | 2020-06-10T18:11:32ZBACKGROUND: Chronic exposure to biomass fuel smoke has been implicated in the development of pulmonary hypertension and right ventricular pressure/volume overload through activation of inflammation, increase in vascular resistance, and endotheli[...]texto impreso
Antiporta, Daniel A. ; Smeeth, Liam ; Gilman, Robert H. ; Miranda, J. Jaime | Cambridge University Press | 2019-02-06T14:53:12ZOBJECTIVE: To evaluate the association between length of residence in an urban area and obesity among Peruvian rural-to-urban migrants. DESIGN: Cross-sectional database analysis of the migrant group from the PERU MIGRANT Study (2007). Exposure [...]texto impreso
Gilman, Robert H. ; Carmen-Orozco, Rogger P. ; Carter, Emma ; Verastegui, Manuela R. | Wiley | 2019-07-04T17:00:18ZNO DISPONIBLEtexto impreso
Salvatore, Phillip P. ; Proaño, Alvaro ; Kendall, Emily A. ; Gilman, Robert H. ; Dowdy, David W. | Oxford University Press | 2018-12-01T00:04:14ZBackground. Substantial individual heterogeneity exists in the clinical manifestations and duration of active tuberculosis. We sought to link the individual-level characteristics of tuberculosis disease to observed population-level outcomes. Met[...]texto impreso
Morgan, Brooks W. ; Leifheit, Kathryn M. ; Romero, Karina M. ; Gilman, Robert H. ; Bernabé-Ortiz, Antonio ; Miranda, J. Jaime ; Feldman, Harold I. ; Lima, John J. ; Checkley, William ; CRONICAS Cohort Study Group | E.U.E.P. European Publishing | 2019-01-25T15:28:05ZBACKGROUND: A recent study found lower self-reported prevalence of tobacco smoking in a peri-urban area of Lima, Peru than previously reported in urban samples. These regions encompass substantial proportions of Peru's population - ones at great[...]texto impreso
Klasen, Elizabeth M. ; Wills, Beatriz ; Naithani, Neha ; Gilman, Robert H. ; Tielsch, James M. ; Chiang, Marilú ; Khatry, Subarna ; Breysse, Patrick N. ; Menya, Diana ; Apaka, Cosmas ; Carter, E. Jane ; Sherman, Charles B. ; Miranda, J. Jaime ; Checkley, William | Elsevier | 2019-02-06T14:52:19ZHousehold air pollution from the burning of biomass fuels is recognized as the third greatest contributor to the global burden of disease. Incomplete combustion of biomass fuels releases a complex mixture of carbon monoxide (CO), particulate ma[...]texto impreso
Lazo-Porras, Maria ; Bernabé-Ortiz, Antonio ; Malaga, German ; Gilman, Robert H. ; Acuna-Villaorduna, Ana ; Cárdenas-Montero, Deborah ; Smeeth, Liam ; Miranda, J. Jaime | Elsevier | 2019-02-06T14:52:14ZIntroduction. Whilst the relationship between lipids and cardiovascular mortality has been well studied and appears to be controversial, very little has been explored in the context of rural-to-urban migration in low-resource settings. Objective[...]texto impreso
Benziger, Catherine P. ; Zavala-Loayza, José Alfredo ; Bernabé-Ortiz, Antonio ; Gilman, Robert H. ; Checkley, William ; Smeeth, Liam ; Malaga, German ; Miranda, Juan Jaime ; CRONICAS Cohort Study Group | BMJ Publishing Group | 2018-11-30T17:17:15ZBACKGROUND: The prevalence of and factors associated with ideal cardiovascular health (ICH) by sociodemographic characteristics in Peru is not well known. METHODS: The American Heart Association's ICH score comprised 3 ideal health factors (bloo[...]texto impreso
Garcia, Hector H. ; Castillo, Yesenia ; Gonzales, Isidro ; Bustos, Javier A. ; Saavedra, Herbert ; Jacob, Louis ; Del Brutto, Oscar H. ; Wilkins, Patricia P. ; Gonzalez, Armando E. ; Gilman, Robert H. ; Cysticercosis Working Group in Peru | Wiley | 2018-11-30T17:17:15ZOBJECTIVE: To evaluate the diagnostic performance of two commercially available ELISA kits, Novalisa® and Ridascreen® , for the detection of antibodies to Taenia solium, compared to serological diagnosis of neurocysticercosis (NCC) by LLGP-EITB [...]texto impreso
Alva, Alicia ; Cangalaya, Carla ; Quiliano, Miguel ; Krebs, Casey ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Public Library of Science | 2019-01-25T15:28:05ZParasitic infections are generally diagnosed by professionals trained to recognize the morphological characteristics of the eggs in microscopic images of fecal smears. However, this laboratory diagnosis requires medical specialists which are lac[...]texto impreso
Benziger, Catherine P. ; Bernabé-Ortiz, Antonio ; Gilman, Robert H. ; Checkley, William ; Smeeth, Liam ; Malaga, German ; Miranda, J. Jaime | Public Library of Science | 2019-02-06T14:53:10ZOBJECTIVE: We aimed to characterize metabolic status by body mass index (BMI) status. METHODS: The CRONICAS longitudinal study was performed in an age-and-sex stratified random sample of participants aged 35 years or older in four Peruvian set[...]texto impreso
Kirwan, Daniela E. ; Ugarte-Gil, Cesar ; Gilman, Robert H. ; Caviedes, Luz ; Rizvi, Hasan ; Ticona, Eduardo ; Chavez, Gonzalo ; Cabrera, Jose Luis ; Matos, Eduardo D. ; Evans, Carlton A. ; Moore, David A. J. ; Friedland, Jon S. ; Lymph Node TB Working Group | American Society for Microbiology | 2019-02-06T14:52:38ZIn this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, [...]texto impreso
Burroughs Pena, Melissa S. ; Bernabé-Ortiz, Antonio ; Carrillo-Larco, Rodrigo M. ; Sanchez, Juan F. ; Quispe, Renato ; Pillay, Timesh D. ; Malaga, German ; Gilman, Robert H. ; Smeeth, Liam ; Miranda, J. Jaime | BMJ Publishing Group | 2019-02-06T14:52:39ZOBJECTIVE: To compare all-cause and cause-specific mortality among 3 distinct groups: within-country, rural-to-urban migrants, and rural and urban dwellers in a longitudinal cohort in Peru. METHODS: The PERU MIGRANT Study, a longitudinal cohort[...]texto impreso
Pisanic, Nora ; Ballard, Sarah-Blythe ; Colquechagua, Fabiola D. ; Francois, Ruthly ; Exum, Natalie ; Yori, Pablo Penataro ; Schwab, Kellogg J. ; Granger, Douglas A. ; Detrick, Barbara ; Olortegui, Maribel Paredes ; Mayta, Holger ; Sánchez, Gerardo J. ; Gilman, Robert H. ; Heaney, Christopher D. ; Vinjé, Jan ; Kosek, Margaret N. | Oxford University Press | 2019-03-05T15:23:28ZBackground: Norovirus is a leading cause of acute gastroenteritis worldwide. Routine norovirus diagnosis requires stool collection. The goal of this study was to develop and validate a noninvasive method to diagnose norovirus to complement stoo[...]texto impreso
Grajeda, Laura M. ; Ivanescu, Andrada ; Saito, Mayuko ; Crainiceanu, Ciprian ; Jaganath, Devan ; Gilman, Robert H. ; Crabtree, Jean E. ; Kelleher, Dermott ; Cabrera, Lilia ; Cama, Vitaliano ; Checkley, William | BMC | 2019-02-06T14:45:34ZBACKGROUND: Childhood growth is a cornerstone of pediatric research. Statistical models need to consider individual trajectories to adequately describe growth outcomes. Specifically, well-defined longitudinal models are essential to characteriz[...]texto impreso
Alcántara, Roberto ; Fuentes, Patricia ; Antiparra, Ricardo ; Santos, Marco ; Gilman, Robert H. ; Kirwan, Daniela E. ; Zimic, Mirko ; Sheen, Patricia | American Society for Microbiology | 2018-11-30T17:17:15ZAlthough pyrazinamide (PZA) is a key component of first and second line tuberculosis treatment regimens, there is no gold standard to determine PZA resistance. Approximately 50% of multidrug-resistant tuberculosis (MDR-TB) and over 90% of extens[...]texto impreso
Geiger, Joseph ; Morton, Bridget A. ; Vasconcelos, Elton Jose Rosas ; Tngrian, Maryam ; Kachani, Malika ; Barrón, Eduardo A. ; Gavidia, Cesar M. ; Gilman, Robert H. ; Angulo, Noelia P. ; Lerner, Richard ; Scott, Tamerin ; Mirrashed, N. Hannah ; Oakley, Brian ; Diniz, Pedro Paulo V. P. | American Society of Tropical Medicine and Hygiene | 2018-11-30T17:17:15ZEhrlichia spp. are emerging infectious pathogens, especially in the Americas. Although Ehrlichia canis is primarily a parasite of dogs, polymerase chain reaction-confirmed human infections have been reported from Mexico, Venezuela, and Costa Ric[...]texto impreso
Sheen, Patricia ; Requena, David ; Gushiken, Eduardo ; Gilman, Robert H. ; Antiparra, Ricardo ; Lucero, Bryan ; Lizárraga, Pilar ; Cieza, Basilio ; Roncal, Elisa ; Grandjean, Louis ; Pain, Arnab ; McNerney, Ruth ; Clark, Taane G. ; Moore, David ; Zimic, Mirko | BMC | 2019-01-25T15:02:14ZBACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes. However, its comple[...]texto impreso
Saito, Mayuko ; Goel-Apaza, Sonia ; Espetia, Susan ; Velasquez, Daniel ; Cabrera, Lilia ; Loli, Sebastian ; Crabtree, Jean E. ; Black, Robert E. ; Kosek, Margaret ; Checkley, William ; Zimic, Mirko ; Bern, Caryn ; Cama, Vitaliano ; Gilman, Robert H. | Oxford University Press | 2020-06-10T18:11:32ZBACKGROUND: Human noroviruses are among the most common enteropathogens globally, and are a leading cause of infant diarrhea in developing countries. However, data measuring the impact of norovirus at the community level are sparse. METHODS: We [...]texto impreso
Castro-Sesquen, Yagahira E. ; Kim, Chloe ; Gilman, Robert H. ; Sullivan, David J. ; Searson, Peter C. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:11ZA nanoparticle-based assay for detection and quantification of Plasmodium falciparum histidine-rich protein 2 (HRP2) in urine and serum is reported. The assay uses magnetic beads conjugated with anti-HRP2 antibody for protein capture and concen[...]texto impreso
Garvey, Brian T. ; Moyano, Luz M. ; Ayvar, Viterbo ; Rodriguez, Silvia ; Gilman, Robert H. ; Gonzalez, Armando E. ; Garcia, Hector H. ; O'Neal, Seth E. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2018-11-30T22:50:33ZNeurocysticercosis causes substantial neurologic morbidity in endemic regions around the world. In this cross-sectional study, we describe the frequency of neurocysticercosis among a presumed high-risk group of people in an endemic community in [...]texto impreso
Moyano, Luz M. ; Saito, Mayuko ; Montano, Silvia M. ; Gonzalvez, Guillermo ; Olaya, Sandra ; Ayvar, Viterbo ; Gonzalez, Isidro ; Larrauri, Luis ; Tsang, Victor C. W. ; Llanos, Fernando ; Rodriguez, Silvia ; Gonzalez, Armando E. ; Gilman, Robert H. ; Garcia, Hector H. | Public Library of Science | 2020-06-10T18:12:16ZBACKGROUND: The prevalence of epilepsy added to inadequate treatment results in chronic morbidity and considerable mortality in poor populations. Neurocysticercosis (NCC), a helminthic disease of the central nervous system, is a leading cause o[...]texto impreso
Ong, Catherine W. M. ; Elkington, Paul T. ; Brilha, Sara ; Ugarte-Gil, Cesar ; Tome-Esteban, Maite T. ; Tezera, Liku B. ; Pabisiak, Przemyslaw J. ; Moores, Rachel C. ; Sathyamoorthy, Tarangini ; Patel, Vimal ; Gilman, Robert H. ; Porter, Joanna C. ; Friedland, Jon S. | Public Library of Science | 2019-02-06T14:53:12ZPulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined. Neutrophils are e[...]texto impreso
Arriola, Carmen S. ; Gonzalez, Armando E. ; Gomez-Puerta, Luis A. ; Lopez-Urbina, Maria T. ; Garcia, Hector H. ; Gilman, Robert H. | Public Library of Science | 2020-06-10T18:12:17ZTaenia solium infection causes severe neurological disease in humans. Even though infection and exposure to swine cysticercosis is scattered throughout endemic villages, location of the tapeworm only explains some of the nearby infections and is[...]texto impreso
Vyas, Kaetan J. ; Danz, David ; Gilman, Robert H. ; Wise, Robert A. ; Leon-Velarde, Fabiola ; Miranda, J. Jaime ; Checkley, William | Mary Ann Liebert | 2019-02-06T14:52:35ZVyas, Kaetan J., David Danz, Robert H. Gilman, Robert A. Wise, Fabiola Leon-Velarde, J. Jaime Miranda, and William Checkley. Noninvasive assessment of excessive erythrocytosis as a screening method for chronic mountain sickness at high altitude.[...]texto impreso
Ponce, Reynaldo ; León-Janampa, Nancy ; Gilman, Robert H. ; Liendo, Ruddy ; Roncal, Elisa ; Luis, Sueline ; Quiñones-García, Stefany ; Silverstein, Zach ; Garcia, Hector H. ; Gonzales, Armando ; Sheen, Patricia ; Zimic, Mirko ; Pajuelo, Monica J. ; Cysticercosis Working Group in Peru | Elsevier | 2018-11-30T02:09:28ZCysticercosis is a worldwide parasitic disease of humans and pigs principally caused by infection with the larvae of the pork tapeworm Taenia solium. Through the use of the recently-made-available T. solium genome, we identified a gene within a [...]texto impreso
Rueda, Daniel ; Furukawa, Roberto ; Fuentes, Patricia ; Comina, Germán ; Rey De Castro, Nicolás G. ; Requena, David ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Medknow Publications | 2018-11-30T02:09:28ZIntroduction: Tuberculosis (TB) is a significant cause of morbidity and mortality worldwide. The patient compliance with the long treatment regimens is essential for successful eradication. Pyrazinamide (PZA) shortens these regimens from 9 to 6 [...]texto impreso
Verastegui, Manuela R. ; Mejia, Alan ; Clark, Taryn ; Gavidia, Cesar M. ; Mamani, Javier ; Ccopa, Fredy ; Angulo, Noelia ; Chile, Nancy ; Carmen, Rogger ; Medina, Roxana ; Garcia, Hector H. ; Rodriguez, Silvia ; Ortega, Ynes ; Gilman, Robert H. | Elsevier | 2019-02-06T14:53:41ZNeurocysticercosis is caused by Taenia solium infecting the central nervous system and is the leading cause of acquired epilepsy and convulsive conditions worldwide. Research into the pathophysiology of the disease and appropriate treatment is h[...]texto impreso
Datta, Sumona ; Alvarado, Keren ; Gilman, Robert H. ; Valencia, Teresa ; Aparicio, Christian ; Ramos, Eric S. ; Montoya, Rosario ; Evans, Carlton A. | Public Library of Science | 2019-07-04T17:00:20ZBACKGROUND: Assessing Mycobacterium tuberculosis (TB) viability by fluorescein diacetate (FDA) microscopy can predict TB culture results, treatment response and infectiousness. However, diverse methods have been published. We aimed to optimise F[...]texto impreso
Gouveia, Mateus H. ; Borda, Victor ; Leal, Thiago P. ; Moreira, Rennan G. ; Bergen, Andrew W. ; Kehdy, Fernanda S. G. ; Alvim, Isabela ; Aquino, Marla M. ; Araujo, Gilderlanio S. ; Araujo, Nathalia M. ; Furlan, Vinicius ; Liboredo, Raquel ; Machado, Moara ; Magalhaes, Wagner C. S. ; Michelin, Lucas A. ; Rodrigues, Maíra R. ; Rodrigues-Soares, Fernanda ; Sant Anna, Hanaisa P. ; Santolalla, Meddly L. ; Scliar, Marília O. ; Soares-Souza, Giordano ; Zamudio, Roxana ; Zolini, Camila ; Bortolini, Maria Catira ; Dean, Michael ; Gilman, Robert H. ; Guio, Heinner ; Rocha, Jorge ; Pereira, Alexandre C. ; Barreto, Mauricio L. ; Horta, Bernardo L. ; Lima-Costa, Maria F. ; Mbulaiteye, Sam M. ; Chanock, Stephen J. ; Tishkoff, Sarah A. ; Yeager, Meredith ; Tarazona-Santos, Eduardo | Wiley | 2020-07-14T00:01:12ZThe Transatlantic Slave Trade transported more than 9 million Africans to the Americas between the early 16th and the mid-19th centuries. We performed a genome-wide analysis using 6,267 individuals from 25 populations to infer how different Afri[...]texto impreso
Gonzalez, Armando E. ; Codd, Ellen E. ; Horton, John ; Garcia, Hector H. ; Gilman, Robert H. | Taylor & Francis | 2019-03-05T15:25:03ZINTRODUCTION: Oxfendazole (methyl [5-(phenylsulphinyl)-1H benzimidazole-2-yl] carbamate) has a particularly long metabolic half-life in ruminants, and its metabolite fenbendazole also has anthelminthic action. A very limited number of drugs are [...]texto impreso
Carrillo-Larco, Rodrigo M. ; Bernabé-Ortiz, Antonio ; Sal Y Rosas, Víctor G. ; Sacksteder, Katherine A. ; Diez-Canseco, Francisco ; Cárdenas, María K. ; Gilman, Robert H. ; Miranda, J. Jaime | Wiley | 2018-11-30T22:50:34ZOBJECTIVES: High body mass index (BMI) and blood pressure (BP) are major contributors to the high burden of non-communicable diseases in adulthood. Individual high-risk and population approaches for prevention require newer strategies to target [...]texto impreso
Miranda, J. Jaime ; Carrillo-Larco, Rodrigo M. ; Gilman, Robert H. ; Avilez, Jose L. ; Smeeth, Liam ; Checkley, William ; Bernabé-Ortiz, Antonio | Human Kinetics | 2019-02-06T14:45:56ZBACKGROUND: Physical inactivity and sedentary behaviors have been linked with impaired health outcomes. Establishing the physical inactivity profiles of a given population is needed to establish program targets and to contribute to international[...]texto impreso
Trompeter, Grace ; Grigsby, Matthew R. ; Miele, Catherine H. ; Wise, Robert A. ; Gilman, Robert H. ; Miranda, J. Jaime ; Bernabé-Ortiz, Antonio ; Checkley, William ; CRONICAS Cohort Study Group | Springer Verlarg | 2018-11-30T22:50:35ZPURPOSE: Body composition is known to influence the development and progression of chronic respiratory diseases (CRDs). We sought to characterize the unique anthropometric phenotypes that present with asthma, chronic obstructive pulmonary diseas[...]texto impreso
Bustos, Javier A. ; Ninaquispe, Berenice E. ; Rodriguez, Silvia ; Castillo, Yesenia ; Yang, Susan Y. ; Gilman, Robert H. ; Dorny, Pierre ; Gabriel, Sarah ; Garcia, Hector H. ; Gonzalez, Armando E. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2019-07-04T17:00:20ZThe pig is the natural intermediate host of Taenia solium, a parasite causing significant burden of disease in both humans and pigs. Porcine cysticercosis is traditionally detected via tongue palpation and slaughterhouse meat inspection, both wi[...]texto impreso
An, Guohua ; Murry, Daryl J. ; Gajurel, Kiran ; Bach, Thanh ; Deye, Greg ; Stebounova, Larissa V. ; Codd, Ellen E. ; Horton, John ; Gonzalez, Armando E. ; Garcia, Hector H. ; Ince, Dilek ; Hodgson-Zingman, Denice ; Nomicos, Effie Y. H. ; Conrad, Thomas ; Kennedy, Jessie ; Jones, Walt ; Gilman, Robert H. ; Winokur, Patricia | American Society for Microbiology | 2019-07-04T17:00:20ZCysticercosis is a parasitic disease that frequently involves the human central nervous system (CNS), and current treatment options are limited. Oxfendazole, a veterinary medicine belonging to the benzimidazole family of anthelmintic drugs, has[...]texto impreso
Fox, Katharine A. ; Kirwan, Daniela E. ; Whittington, Ashley M. ; Krishnan, Nitya ; Robertson, Brian D. ; Gilman, Robert H. ; López, José W. ; Singh, Shivani ; Porter, Joanna C. ; Friedland, Jon S. | American Thoracic Society | 2018-11-30T22:50:35ZRATIONALE: Platelets may interact with the immune system in tuberculosis (TB) to regulate human inflammatory responses that lead to morbidity and spread of infection. OBJECTIVES: To identify a functional role of platelets in the innate inflammat[...]texto impreso
Málaga-Machaca, Edith S. ; Romero-Ramirez, Alessandra ; Gilman, Robert H. ; Astupiña-Figueroa, Sofía ; Angulo, Noelia ; Florentini, Alejandro ; Lovon-Luque, Cinthya J. ; Gonza, Remo A. ; Del Carpio-Sanz, Ada ; Cabello, Ines ; Camargo, Rosina ; Recuenco, Fernando ; Barrueta-Soria, Liliam A. ; Verastegui, Manuela R. ; Calderón, Maritza ; Mayta, Holger | Public Library of Science | 2019-01-25T15:28:07ZBACKGROUND: Detection of Trypanosoma cruzi antigens in clinical samples is considered an important diagnostic tool for Chagas disease. The production and use of polyclonal antibodies may contribute to an increase in the sensitivity of immunodiag[...]texto impreso
Zamudio, Roxana ; Pereira, Latife ; Rocha, Carolina D. ; Berg, Douglas E. ; Muniz-Queiroz, Thais ; Sant Anna, Hanaisa P. ; Cabrera, Lilia ; Combe, Juan M. ; Herrera, Phabiola ; Jahuira, Martha H. ; Leao, Felipe B. ; Lyon, Fernanda ; Prado, William A. ; Rodrigues, Maíra R. ; Rodrigues-Soares, Fernanda ; Santolalla, Meddly L. ; Zolini, Camila ; Silva, Aristobolo M. ; Gilman, Robert H. ; Tarazona-Santos, Eduardo ; Kehdy, Fernanda S. G. | Springer | 2019-02-06T14:52:19ZBackground. Gastric adenocarcinoma is associated with chronic infection by Helicobacter pylori and with the host inflammatory response triggered by it, with substantial inter-person variation in the immune response profile due to host genetic fa[...]texto impreso
Muro, Claudio ; Gomez-Puerta, Luis A. ; Flecker, Robert H. ; Gamboa, Ricardo ; Barreto, Percy Vilchez ; Dorny, Pierre ; Tsang, Victor C. W. ; Gilman, Robert H. ; Gonzalez, Armando E. ; Garcia, Hector H. ; O'Neal, Seth E. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2019-01-25T15:28:08ZThe lentil lectin glycoprotein enzyme-linked immunoelectrotransfer blot (LLGP EITB, reported sensitivity 99% and specificity 100%) is used as a serologic marker of exposure to Taenia solium in pigs. However, only a limited number of parasites ha[...]texto impreso
Codd, Ellen E. ; Ng, Hanna H. ; McFarlane, Claire ; Riccio, Edward S. ; Doppalapudi, Rupa ; Mirsalis, Jon C. ; Horton, R. John ; Gonzalez, Armando E. ; Garcia, H. Hugo ; Gilman, Robert H. | Sage publications | 2019-02-06T14:52:38ZA 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thymus. Female rats had greater oxfendazole exposure and exhibited toxicities at lower doses than did males. Decrea[...]texto impreso
de Ferrari, Aldo ; Miranda, J. Jaime ; Gilman, Robert H. ; Davila-Roman, Victor G. ; Leon-Velarde, Fabiola ; Rivera-Ch, Maria ; Huicho, Luis ; Bernabé-Ortiz, Antonio ; Wise, Robert A. ; Checkley, William | Elsevier | 2020-06-10T18:11:32ZBACKGROUND: Excessive erythrocytosis (EE) is a prevalent condition in populations living at high altitudes (> 2,500 m above sea level). Few large population-based studies have explored the association between EE and multiple subject-specific t[...]texto impreso
Yager, Jessica E. ; Lozano Beltran, Daniel F. ; Torrico, Faustino ; Gilman, Robert H. ; Bern, Caryn | Elsevier | 2019-02-06T14:52:34ZBACKGROUND: Though the incidence of new Trypanosoma cruzi infections has decreased significantly in endemic regions in the Americas, medical professionals continue to encounter a high burden of resulting Chagas disease among infected adults. The[...]texto impreso
Jaganath, Devan ; Miranda, J. Jaime ; Gilman, Robert H. ; Wise, Robert A. ; Diette, Gregory B. ; Miele, Catherine H. ; Bernabé-Ortiz, Antonio ; Checkley, William | BMC | 2019-02-06T14:53:35ZBACKGROUND: It is unclear how geographic and social diversity affects the prevalence of chronic obstructive pulmonary disease (COPD). We sought to characterize the prevalence of COPD and identify risk factors across four settings in Peru with va[...]texto impreso
Patra, Kailash P. ; Saito, Mayuko ; Atluri, Vidya L. ; Rolan, Hortensia G. ; Young, Briana ; Kerrinnes, Tobias ; Smits, Henk ; Ricaldi, Jessica N. ; Gotuzzo, Eduardo ; Gilman, Robert H. ; Tsolis, Renee M. ; Vinetz, Joseph M. | Public Library of Science | 2020-06-10T18:12:16ZHuman brucellosis is most commonly diagnosed by serology based on agglutination of fixed Brucella abortus as antigen. Nucleic acid amplification techniques have not proven capable of reproducibly and sensitively demonstrating the presence of B[...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; Tracey, Brian H. ; López, José W. ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Lee, Gwenyth O'Neil ; Caviedes, Luz ; Cabrera, Jose Luis ; Salas, Antonio ; Ticona, Eduardo ; Kirwan, Daniela E. ; Friedland, Jon S. ; Evans, Carlton A. ; Moore, David A. ; Gilman, Robert H. | BMJ Publishing Group | 2019-02-06T14:51:43ZINTRODUCTION: Cough is a key symptom of tuberculosis (TB) as well as the main cause of transmission. However, a recent literature review found that cough frequency (number of coughs per hour) in patients with TB has only been studied once, in 19[...]texto impreso
Halperin, Anthony ; Pajuelo, Monica ; Tornheim, Jeffrey A. ; Vu, Nancy ; Carnero, Andres M. ; Galdos-Cardenas, Gerson ; Ferrufino, Lisbeth ; Camacho, Marilyn ; Justiniano, Juan ; Colanzi, Rony ; Bowman, Natalie M. ; Morris, Tiffany ; MacDougall, Hamish ; Bern, Caryn ; Moore, Steven T. ; Gilman, Robert H. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:34ZAutonomic dysfunction is common in Chagas disease and diabetes. Patients with either condition complicated by cardiac autonomic dysfunction face increased mortality, but no clinical predictors of autonomic dysfunction exist. Pupillary light refl[...]texto impreso
Datta, Sumona ; Gilman, Robert H. ; Montoya, Rosario ; Quevedo Cruz, Luz ; Valencia, Teresa ; Huff, Doug ; Saunders, Matthew J. ; Evans, Carlton A. | European Respiratory Society | 2020-07-14T00:01:06ZBACKGROUND: Global tuberculosis policy increasingly emphasises broad tuberculosis impacts and highlights the lack of evidence concerning tuberculosis-related quality of life (QOL). METHODS: Participants were recruited in 32 Peruvian communities [...]texto impreso
Meinzen, Christopher ; Proaño, Alvaro ; Gilman, Robert H. ; Caviedes, Luz ; Coronel, Jorge ; Zimic, Mirko ; Sheen, Patricia | Elsevier | 2019-02-06T14:45:55ZBACKGROUND: Pyrazinamide (PZA) is the most important drug against the latent stage of tuberculosis (TB) and is used in both first and second line treatment regimens. The continued increase in multi-drug resistant TB and the prevalence of PZA res[...]texto impreso
Wingfield, Tom ; Tovar, Marco A. ; Huff, Doug ; Boccia, Delia ; Montoya, Rosario ; Ramos, Eric ; Datta, Sumona ; Saunders, Matthew J. ; Lewis, James J. ; Gilman, Robert H. ; Evans, Carlton A. | World Health Organization | 2019-01-25T15:02:14ZOBJECTIVE: To evaluate the impact of socioeconomic support on tuberculosis preventive therapy initiation in household contacts of tuberculosis patients and on treatment success in patients. METHODS: A non-blinded, household-randomized, controlle[...]texto impreso
Martin, Laura J. ; Roper, Martha H. ; Grandjean, Louis ; Gilman, Robert H. ; Coronel, Jorge ; Caviedes, Luz ; Friedland, Jon S. ; Moore, David A. J. | BMC | 2019-02-06T14:45:55ZBACKGROUND: Early identification of patients with drug-resistant tuberculosis (DR-TB) increases the likelihood of treatment success and interrupts transmission. Resource-constrained settings use risk profiling to ration the use of drug suscepti[...]texto impreso
Martin, Diana L. ; Marks, Morgan ; Galdos-Cardenas, Gerson ; Gilman, Robert H. ; Goodhew, Brook ; Ferrufino, Lisbeth ; Halperin, Anthony ; Sanchez, Gerardo ; Verastegui, Manuela ; Escalante, Patricia ; Náquira, César ; Levy, Michael Z. ; Bern, Caryn | American Society of Tropical Medicine and Hygiene | 2020-06-10T18:11:31ZChagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major cause of morbidity and mortality in Central and South America. Geographic variations in the sensitivity of serologic diagnostic assays to T. cruzi may reflect differe[...]texto impreso
Lazo-Porras, Maria ; Bernabé-Ortiz, Antonio ; Ruiz-Alejos, Andrea ; Smeeth, Liam ; Gilman, Robert H. ; Checkley, William ; Malaga, German ; Jaime Miranda, J. | Elsevier | 2019-12-06T21:04:48ZAIMS: This study aimed (1) to estimate the prevalence of prediabetes according to different definitions, (2) to evaluate regression to normal glucose levels and progression towards T2DM, and (3) to determine factors associated with regression an[...]texto impreso
Lazo-Porras, Maria ; Bernabé-Ortiz, Antonio ; Ruiz-Alejos, Andrea ; Smeeth, Liam ; Gilman, Robert H. ; Checkley, William ; Malaga, German ; Miranda, J. Jaime | Elsevier | 2020-07-14T00:02:30ZAIMS: This study aimed to (1) estimate the prevalence of prediabetes according to different definitions, (2) evaluate regression to normal glucose levels and progression towards T2DM, and (3) determine factors associated with regression and prog[...]texto impreso
Burroughs Pena, Melissa ; Romero, Karina M. ; Velazquez, Eric J. ; Davila-Roman, Victor G. ; Gilman, Robert H. ; Wise, Robert A. ; Miranda, J. Jaime ; Checkley, William | American Heart Association | 2019-02-06T14:52:36ZHousehold air pollution from biomass fuel use affects 3 billion people worldwide; however, few studies have examined the relationship between biomass fuel use and blood pressure. We sought to determine if daily biomass fuel use was associated w[...]texto impreso
O'Neal, Seth E. ; Moyano, Luz M. ; Ayvar, Viterbo ; Rodriguez, Silvia ; Gavidia, Cesar ; Wilkins, Patricia P. ; Gilman, Robert H. ; Garcia, Hector H. ; Gonzalez, Armando E. | Public Library of Science | 2020-06-10T18:12:17ZBACKGROUND: Taenia solium is a major cause of preventable epilepsy in developing nations. Screening and treatment of human intestinal stage infection (taeniasis) within high-risk foci may reduce transmission and prevent epilepsy by limiting hu[...]texto impreso
Carrillo-Larco, Rodrigo M. ; Miranda, J. Jaime ; Gilman, Robert H. ; Medina-Lezama, Josefina ; Chirinos-Pacheco, Julio A. ; Muñoz-Retamozo, Paola V. ; Smeeth, Liam ; Checkley, William ; Bernabé-Ortiz, Antonio ; CRONICAS Cohort Study Group | BMC | 2019-01-25T16:03:19ZBACKGROUND: Chronic Kidney Disease (CKD) represents a great burden for the patient and the health system, particularly if diagnosed at late stages. Consequently, tools to identify patients at high risk of having CKD are needed, particularly in l[...]texto impreso
Hilmers, Angela ; Bernabé-Ortiz, Antonio ; Gilman, Robert H. ; McDermott, Ann Y. ; Smeeth, Liam ; Miranda, J. Jaime | Springer | 2019-02-06T14:45:35ZTo investigate whether socioeconomic status (SES) and acculturation predict overweight/obesity risk as well as the mediating effect of physical activity (PA) in the context of internal migration. Cross-sectional study of 587 rural-to-urban migra[...]texto impreso
Saunders, Matthew J. ; Wingfield, Tom ; Tovar, Marco A. ; Baldwin, Matthew R. ; Datta, Sumona ; Zevallos, Karine ; Montoya, Rosario ; Valencia, Teresa R. ; Friedland, Jon S. ; Moulton, Larry H. ; Gilman, Robert H. ; Evans, Carlton A. | Elsevier | 2019-01-25T15:02:14ZBACKGROUND: Contacts of tuberculosis index cases are at increased risk of developing tuberculosis. Screening, preventive therapy, and surveillance for tuberculosis are underused interventions in contacts, particularly adults. We developed a scor[...]texto impreso
Bui, Anthony L. ; Moscoso, Miguel G. ; Bernabé-Ortiz, Antonio ; Checkley, William ; Gilman, Robert H. ; Smeeth, Liam ; Miranda, J. Jaime | BMC | 2019-07-04T16:59:17ZBackground: Individuals' self-perceptions of weight often differ from objective measurements of body fat. This study aimed to 1) measure agreement between self-perceptions of weight and objective measurement of body fat by bioelectric impedance [...]texto impreso
Ruiz-Alejos, Andrea ; Carrillo-Larco, Rodrigo M. ; Miranda, J. Jaime ; Gilman, Robert H. ; Smeeth, Liam ; Bernabé-Ortiz, Antonio | Cambridge University Press | 2019-07-04T17:00:24ZOBJECTIVE: To determine the association between excess body fat, assessed by skinfold thickness, and the incidence of type 2 diabetes mellitus (T2DM) and hypertension (HT). DESIGN: Data from the ongoing PERU MIGRANT Study were analysed. The outc[...]texto impreso
Schwartz, Noah G. ; Rattner, Adi ; Schwartz, Alan R. ; Mokhlesi, Babak ; Gilman, Robert H. ; Bernabé-Ortiz, Antonio ; Miranda, J. Jaime ; Checkley, William ; CRONICAS Cohort Study Group | Oxford University Press | 2019-02-06T14:53:40ZSTUDY OBJECTIVES: Sleep disordered breathing (SDB) is a highly prevalent condition in high-income countries, with major consequences for cardiopulmonary health, public safety, healthcare utilization, and mortality. However, its prevalence and ef[...]texto impreso
Taype-Rondan, Álvaro ; Bernabé-Ortiz, Antonio ; Alvarado, German F. ; Gilman, Robert H. ; Smeeth, Liam ; Miranda, J. Jaime | BMC | 2019-01-25T16:03:20ZBACKGROUND: Previous studies have found mixed results about cigarette and alcohol consumption patterns among rural-to-urban migrants. Moreover, there are limited longitudinal data about consumption patterns in this population. As such, this stud[...]texto impreso
Carrillo-Larco, Rodrigo M. ; Saavedra-Garcia, Lorena ; Miranda, J. Jaime ; Sacksteder, Katherine A. ; Diez-Canseco, Francisco ; Gilman, Robert H. ; Bernabé-Ortiz, Antonio | MDPI | 2018-11-30T22:50:37ZDespite the negative effects of high sodium and low potassium consumption on cardiovascular health, their consumption has not been quantified in sites undergoing urbanization. We aimed to determine the sodium and potassium consumption in a semi-[...]texto impreso
Gravitt, Patti E. ; Marks, Morgan ; Kosek, Margaret ; Huang, Christine ; Cabrera, Lilia ; Olortegui, Maribel Paredes ; Medrano, Alberto Mejia ; Trigoso, Dixner R. ; Qureshi, Sarah ; Bardales, Gustavo S. ; Manrique-Hinojosa, Javier ; Cardenas, Albert Z. ; Larraondo, Manuel A. ; Cok, Jaime ; Qeadan, Fares ; Siracusa, Mark ; Gilman, Robert H. | Oxford University Press | 2019-02-06T14:57:40ZBACKGROUND: An ecological correlation between invasive cervical cancer incidence and burden of soil-transmitted helminths (STH) is hypothesized to explain the excess in detectable human papillomavirus (HPV) infection in Latin America, via a glo[...]texto impreso
Ruiz-Grosso, Paulo ; Miranda, J. Jaime ; Gilman, Robert H. ; Walker, Blake Byron ; Carrasco-Escobar, Gabriel ; Varela-Gaona, Marco ; Diez-Canseco, Francisco ; Huicho, Luis ; Checkley, William ; Bernabé-Ortiz, Antonio | Elsevier | 2019-02-06T14:52:12ZPURPOSE: To map the geographical distribution and spatial clustering of depressive symptoms cases in an area of Lima, Peru. METHODS: Presence of depressive symptoms suggesting a major depressive episode was assessed using a short version of the [...]texto impreso
Datta, Sumona ; Sherman, Jonathan M. ; Tovar, Marco A. ; Bravard, Marjory A. ; Valencia, Teresa ; Montoya, Rosario ; Quino, Willi ; D'Arcy, Nikki ; Ramos, Eric S. ; Gilman, Robert H. ; Evans, Carlton A. | Oxford University Press | 2019-01-25T16:03:21ZBackground: Sputum from patients with tuberculosis contains subpopulations of metabolically active and inactive Mycobacterium tuberculosis with unknown implications for infectiousness. Methods: We assessed sputum microscopy with fluorescein diac[...]texto impreso
Gonzalez, Armando E. ; Bustos, Javier A. ; Garcia, Hector H. ; Rodriguez, Silvia ; Zimic, Mirko ; Castillo, Yesenia ; Praet, Nicolas ; Gabriel, Sarah ; Gilman, Robert H. ; Dorny, Pierre | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:38ZTaenia solium cysticercosis is a common parasitic infection of humans and pigs. We evaluated the posttreatment evolution of circulating parasite-specific antigen titers in 693 consecutive blood samples from 50 naturally infected cysticercotic p[...]texto impreso
Kaplinski, Michelle ; Jois, Malasa ; Galdos-Cardenas, Gerson ; Rendell, Victoria R. ; Shah, Vishal ; Do, Rose Q. ; Marcus, Rachel ; Pena, Melissa S. Burroughs ; Abastoflor, Maria Del Carmen ; LaFuente, Carlos ; Bozo, Ricardo ; Valencia, Edward ; Verastegui, Manuela ; Colanzi, Rony ; Gilman, Robert H. ; Bern, Caryn | Oxford University Press | 2019-02-06T14:52:17ZBACKGROUND: We studied women and their infants to evaluate risk factors for congenital transmission and cardiomyopathy in Trypanosoma cruzi-infected women. METHODS: Women provided data and blood for serology and quantitative polymerase chain rea[...]texto impreso
León-Janampa, Nancy ; Zimic, Mirko ; Shinkaruk, Svitlana ; Quispe-Marcatoma, J. ; Gutarra, Abel ; Le Bourdon, Gwénaëlle ; Gayot, Marion ; Changanaqui, Katherina ; Gilman, Robert H. ; Fouquet, Eric ; Sheen, Patricia ; Szlosek, Magali | IOP Publishing | 2020-07-14T00:02:31ZMycobacterium tuberculosis is the cause of one of the diseases with the highest mortality and morbidity rate in the Americas and in the world. In developing countries, the diagnosis of tuberculosis (TB) is based on baciloscopy and bacteriologica[...]texto impreso
Garcia, Hector H. ; Gonzalez, Armando E. ; Gilman, Robert H. | American Society for Microbiology | 2020-07-14T00:01:11ZTaenia solium neurocysticercosis (NCC) is endemic in most of the world and contributes significantly to the burden of epilepsy and other neurological morbidity. Also present in developed countries because of immigration and travel, NCC is one of[...]texto impreso
Watts, Nathaniel S. ; Pajuelo, Monica ; Clark, Taryn ; Loader, Maria-Cristina I. ; Verastegui, Manuela R. ; Sterling, Charles ; Friedland, Jon S. ; Garcia, Hector H. ; Gilman, Robert H. | Public Library of Science | 2020-06-10T18:12:20ZBACKGROUND: Neurocysticercosis is a leading cause of seizures and epilepsy in most of the world, and it occurs when Taenia solium larval cysts infect the central nervous system. T. solium tapeworm infection is endemic in much of Peru, but there[...]texto impreso
Iyengar, Meera F. ; Soto, Luis F. ; Requena, David ; Ruiz-Alejos, Andrea O. ; Huaylinos, Yvonne ; Velasquez, Ricardo ; Bernabé-Ortiz, Antonio ; Gilman, Robert H. | Elsevier | 2020-07-14T00:02:29ZAims: Explore potential of 31 tear biomarkers involved in screening for diabetic peripheral neuropathy (DPN). Assess the utility of aesthesiometry for measuring corneal damage in DPN and determine optimal cutoff point for detecting DPN. Methods:[...]texto impreso
Grandjean, Louis ; Iwamoto, Tomotada ; Lithgow, Anna ; Gilman, Robert H. ; Arikawa, Kentaro ; Nakanishi, Noriko ; Martin, Laura ; Castillo, Edith ; Alarcon, Valentina ; Coronel, Jorge ; Solano, Walter ; Aminian, Minoo ; Guezala, Claudia ; Rastogi, Nalin ; Couvin, David ; Sheen, Patricia ; Zimic, Mirko ; Moore, David A. J. | Public Library of Science | 2019-02-06T14:53:10ZBACKGROUND: The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the sprea[...]texto impreso
Cardenas, Maria Kathia ; Mirelman, Andrew J. ; Galvin, Cooper J. ; Lazo-Porras, Maria ; Pinto, Miguel ; Miranda, J. Jaime ; Gilman, Robert H. | BMC | 2019-02-06T14:52:14ZBACKGROUND: Diabetes mellitus is a public health challenge worldwide, and roughly 25% of patients with diabetes in developing countries will develop at least one foot ulcer during their lifetime. The gravest outcome of an ulcerated foot is amput[...]texto impreso
Rothstein, Jessica D. ; Caulfield, Laura E. ; Broaddus-Shea, Elena T. ; Muschelli, John ; Gilman, Robert H. ; Winch, Peter J. | Elsevier | 2019-07-04T16:59:16ZNO DISPONIBLEtexto impreso
Wingfield, Tom ; Tovar, Marco A. ; Huff, Doug ; Boccia, Delia ; Montoya, Rosario ; Ramos, Eric ; Lewis, James J. ; Gilman, Robert H. ; Evans, Carlton A. | European Respiratory Society | 2019-02-06T14:48:08ZThe End TB Strategy mandates that no tuberculosis (TB)-affected households face catastrophic costs due to TB. However, evidence is limited to evaluate socioeconomic support to achieve this change in policy and practice. The objective of the pres[...]texto impreso
Castillo-Neyra, Ricardo ; Chou Chu, Lily ; Quispe-Machaca, Victor ; Ancca-Juarez, Jenny ; Malaga Chavez, Fernando S. ; Bastos Mazuelos, Milagros ; Náquira, César ; Bern, Caryn ; Gilman, Robert H. ; Levy, Michael Z. | Elsevier | 2019-02-06T14:53:12ZBACKGROUND: Chagas disease, a vector-borne disease transmitted by triatomine bugs and caused by the parasite Trypanosoma cruzi, affects millions of people in the Americas. In Arequipa, Peru, indoor residual insecticide spraying campaigns are rou[...]texto impreso
Quispe, Renato ; Benziger, Catherine P. ; Bazo-Alvarez, Juan Carlos ; Howe, Laura D. ; Checkley, William ; Gilman, Robert H. ; Smeeth, Liam ; Bernabé-Ortiz, Antonio ; Miranda, J. Jaime | Elsevier | 2019-02-06T14:45:58ZBACKGROUND: Variations in the distribution of cardiovascular disease and risk factors by socioeconomic status (SES) have been described in affluent societies, yet a better understanding of these patterns is needed for most low- and middle-incom[...]texto impreso
Knight, Gwenan M. ; Zimic, Mirko ; Funk, Sebastian ; Gilman, Robert H. ; Friedland, Jon S. ; Grandjean, Louis | The Royal Society | 2018-11-30T23:41:30ZThe relative fitness of drug-resistant versus susceptible bacteria in an environment dictates resistance prevalence. Estimates for the relative fitness of resistant Mycobacterium tuberculosis (Mtb) strains are highly heterogeneous and mostly der[...]texto impreso
Wingfield, Tom ; Schumacher, Samuel G. ; Sandhu, Gurjinder ; Tovar, Marco A. ; Zevallos, Karine ; Baldwin, Matthew R. ; Montoya, Rosario ; Ramos, Eric S. ; Jongkaewwattana, Chulanee ; Lewis, James J. ; Gilman, Robert H. ; Friedland, Jon S. ; Evans, Carlton A. | Oxford University Press | 2020-06-10T18:12:15ZBACKGROUND: Unlike other respiratory infections, tuberculosis diagnoses increase in summer. We performed an ecological analysis of this paradoxical seasonality in a Peruvian shantytown over 4 years. METHODS: Tuberculosis symptom-onset and diagn[...]texto impreso
Steinberg, Hannah E. ; Russo, Paul ; Angulo, Noelia ; Ynocente, Raúl ; Montoya, Cristina ; Diestra, Andrea ; Ferradas, Cusi ; Schiaffino, Francesca ; Florentini, Edgar ; Jimenez, Juan ; Calderón, Maritza ; Carruthers, Vern B. ; Gilman, Robert H. ; Liotta, Lance ; Luchini, Alessandra | Elsevier | 2018-11-30T23:41:30ZDiagnosis of clinical toxoplasmosis remains a challenge, thus limiting the availability of human clinical samples. Though murine models are an approximation of human response, their definitive infection status and tissue availability make them c[...]texto impreso
Messenger, Louisa A. ; Gilman, Robert H. ; Verastegui, Manuela ; Galdos-Cardenas, Gerson ; Sanchez, Gerardo ; Valencia, Edward ; Sanchez, Leny ; Malaga, Edith ; Rendell, Victoria R. ; Jois, Malasa ; Shah, Vishal ; Santos, Nicole ; Abastoflor, Maria Del Carmen ; LaFuente, Carlos ; Colanzi, Rony ; Bozo, Ricardo ; Bern, Caryn | Oxford University Press | 2019-01-25T16:03:22ZBackground: Congenital Trypanosoma cruzi transmission is now estimated to account for 22% of new infections, representing a significant public health problem across Latin America and internationally. Treatment during infancy is highly efficaciou[...]texto impreso
Miranda, J. Jaime ; Bernabé-Ortiz, Antonio ; Diez-Canseco, Francisco ; Malaga, German ; Cárdenas, María K. ; Carrillo-Larco, Rodrigo M. ; Lazo-Porras, Maria ; Moscoso-Porras, Miguel ; Pesantes, M. Amalia ; Ponce, Vilarmina ; Araya, Ricardo ; Beran, David ; Busse, Peter ; Boggio, Oscar ; Checkley, William ; García, Patricia J. ; Huicho, Luis ; Leon-Velarde, Fabiola ; Lescano, Andres G. ; Mohr, David-C. ; Pan, William ; Peiris, David ; Perel, Pablo ; Rabadan-Diehl, Cristina ; Rivera-Chira, Maria ; Sacksteder, Katherine ; Smeeth, Liam ; Trujillo, Antonio J. ; Wells, Jonathan C. K. ; Yan, Lijing-L. ; Garcia, Hector H. ; Gilman, Robert H. | BMC | 2019-02-06T14:51:22ZHuman capital requires opportunities to develop and capacity to overcome challenges, together with an enabling environment that fosters critical and disruptive innovation. Exploring such features is necessary to establish the foundation of solid[...]texto impreso
Bloomfield, Gerald S. ; Xavier, Denis ; Belis, Deshiree ; Alam, Dewan ; Davis, Patricia ; Dorairaj, Prabhakaran ; Ghannem, Hassen ; Gilman, Robert H. ; Kamath, Deepak ; Kimaiyo, Sylvester ; Levitt, Naomi ; Martinez, Homero ; Mejicano, Gabriela ; Miranda, J. Jaime ; Koehlmoos, Tracey Perez ; Rabadan-Diehl, Cristina ; Ramirez-Zea, Manuel ; Rubinstein, Adolfo ; Sacksteder, Katherine A. ; Steyn, Krisela ; Tandon, Nikhil ; Vedanthan, Rajesh ; Wolbach, Tracy ; Wu, Yangfeng ; Yan, Lijing L. | Elsevier | 2019-02-06T14:51:17ZStemming the tide of noncommunicable diseases (NCDs) worldwide requires a multipronged approach. Although much attention has been paid to disease control measures, there is relatively little consideration of the importance of training the next [...]texto impreso
Carrillo-Larco, Rodrigo M. ; Miranda, J. Jaime ; Gilman, Robert H. ; Checkley, William ; Smeeth, Liam ; Bernabé-Ortiz, Antonio ; CRONICAS Cohort Study Group | BMJ Publishing Group | 2018-11-30T23:41:30ZBACKGROUND: Studies have reported the incidence/risk of becoming obese, but few have described the trajectories of body mass index (BMI) and waist circumference (WC) over time, especially in low/middle-income countries. We assessed the trajector[...]texto impreso
Grandjean, Louis ; Gilman, Robert H. ; Martin, Laura ; Soto, Esther ; Castro, Beatriz ; Lopez, Sonia ; Coronel, Jorge ; Castillo, Edith ; Alarcon, Valentina ; Lopez, Virginia ; San Miguel, Angela ; Quispe, Neyda ; Asencios, Luis ; Dye, Christopher ; Moore, David A. J. | Public Library of Science | 2019-02-06T14:53:08ZBACKGROUND: The "fitness" of an infectious pathogen is defined as the ability of the pathogen to survive, reproduce, be transmitted, and cause disease. The fitness of multidrug-resistant tuberculosis (MDRTB) relative to drug-susceptible tuberc[...]texto impreso
Ballard, Sarah-Blythe ; Saito, Mayuko ; Mirelman, Andrew J. ; Bern, Caryn ; Gilman, Robert H. | Lippincott, Williams & Wilkins | 2019-02-06T14:52:18ZPURPOSE OF REVIEW: We highlight recent advances relevant to understanding norovirus infections in the tropics, both in populations living in developing settings and travelers to these regions. RECENT FINDINGS: Because of the decrease in diarrhea[...]texto impreso
Rendell, Victoria R. ; Gilman, Robert H. ; Valencia, Edward ; Galdos-Cardenas, Gerson ; Verastegui, Manuela ; Sanchez, Leny ; Acosta, Janet ; Sanchez, Gerardo ; Ferrufino, Lisbeth ; LaFuente, Carlos ; Abastoflor, Maria Del Carmen ; Colanzi, Rony ; Bern, Caryn | Public Library of Science | 2019-02-06T14:53:12ZBACKGROUND: Congenital transmission is a major source of new Trypanosoma cruzi infections, and as vector and blood bank control continue to improve, the proportion due to congenital infection will grow. A major unanswered question is why report[...]texto impreso
Noazin, Sassan ; Lee, Jessica A. ; Malaga, Edith S. ; Ayala, Edward Valencia ; Condori, Beth J. ; Roca, Cristian ; Lescano, Andres G. ; Bern, Caryn ; Castillo, Walter ; Mayta, Holger ; Menduiña, Maria Carmen ; Verastegui, Manuela R. ; Tinajeros, Freddy ; Gilman, Robert H. ; Chagas Working Group in Bolivia and Peru | Oxford University Press | 2018-12-03T17:02:50ZBackground: Congenital Trypanosoma cruzi accounts for an estimated 22% of new cases in Latin America. However, neonatal diagnosis is challenging, as 9-month follow-up for IgG testing is poor, qPCR is not routinely performed, and micromethod miss[...]texto impreso
Nadimpalli, Maya L. ; Marks, Sara J. ; Montealegre, Maria Camila ; Gilman, Robert H. ; Pajuelo, Monica J. ; Saito, Mayuko ; Tsukayama, Pablo ; Njenga, Sammy M. ; Kiiru, John ; Swarthout, Jenna ; Islam, Mohammad Aminul ; Julian, Timothy R. ; Pickering, Amy J. | Nature Research | 2020-07-14T00:02:35ZAntimicrobial resistance (AMR) is a growing public health challenge that is expected to disproportionately burden lower- and middle-income countries (LMICs) in the coming decades. Although the contributions of human and veterinary antibiotic mis[...]texto impreso
Gaviola, Chelsea ; Miele, Catherine H. ; Wise, Robert A. ; Gilman, Robert H. ; Jaganath, Devan ; Miranda, J. Jaime ; Bernabé-Ortiz, Antonio ; Hansel, Nadia N. ; Checkley, William | BMJ Publishing Group | 2019-02-06T14:57:42ZBACKGROUND: Urbanisation is an important contributor to the prevalence of asthma worldwide, and the burden of this effect in low-income and middle-income countries undergoing rapid industrialisation appears to be growing. We sought to characte[...]texto impreso
Carrillo-Larco, Rodrigo M. ; Miranda, J. Jaime ; Gilman, Robert H. ; Narvaez-Guerra, Offdan ; Herrera-Enriquez, Karela ; Medina-Lezama, Josefina ; Smeeth, Liam ; Checkley, William ; Bernabé-Ortiz, Antonio | Mary Ann Liebert | 2019-12-06T20:57:49ZBackground: Kidney health needs to be studied in low- and middle-income countries with populations living at high altitude and undergoing urbanization. We studied whether greater level of urbanization was associated with worse kidney function a[...]texto impreso
Carrillo-Larco, Rodrigo M. ; Miranda, J. Jaime ; Gilman, Robert H. ; Narvaez-Guerra, Offdan ; Herrera-Enriquez, Karela ; Medina-Lezama, Josefina ; Smeeth, Liam ; Checkley, William ; Bernabé-Ortiz, Antonio | Mary Ann Liebert | 2019-07-04T17:01:22ZCarrillo-Larco, Rodrigo M., J. Jaime Miranda, Robert H. Gilman, Offdan Narvaez-Guerra, Karela Herrera-Enriquez, Josefina Medina-Lezama, Liam Smeeth, William Checkley, and Antonio Bernabe-Ortiz; on behalf of the CRONICAS Cohort Study Group. Urban[...]texto impreso
Miele, Catherine H. ; Jaganath, Devan ; Miranda, J. Jaime ; Bernabé-Ortiz, Antonio ; Gilman, Robert H. ; Johnson, Caroline M. ; Diette, Gregory B. ; Wise, Robert A. ; Checkley, William | Taylor & Francis | 2019-02-06T14:52:17ZOBJECTIVE: Risk factors beyond tobacco smoking associated with chronic bronchitis are not well understood. We sought to describe the prevalence and risk factors of chronic bronchitis across four distinct settings in Peru with overall low prevale[...]texto impreso
Lazo-Porras, Maria ; Bernabé-Ortiz, Antonio ; Quispe, Renato ; Malaga, German ; Smeeth, Liam ; Gilman, Robert H. ; Checkley, William ; Miranda, J. Jaime ; CRONICAS Cohort Study Group | Elsevier | 2019-01-25T16:20:55ZBACKGROUND: Geographical and environmental features such as urbanization and altitude may influence individual's lipid profiles because of the diversity of human-environment interactions including lifestyles. OBJECTIVE: To characterize the assoc[...]texto impreso
Paris, Luisa ; Magni, Ruben ; Zaidi, Fatima ; Araujo, Robyn ; Saini, Neal ; Harpole, Michael ; Coronel, Jorge ; Kirwan, Daniela E. ; Steinberg, Hannah ; Gilman, Robert H. ; Petricoin, Emanuel F. ; Nisini, Roberto ; Luchini, Alessandra ; Liotta, Lance | American Association for the Advancement of Sience | 2019-01-25T16:20:55ZAn accurate urine test for pulmonary tuberculosis (TB), affecting 9.6 million patients worldwide, is critically needed for surveillance and treatment management. Past attempts failed to reliably detect the mycobacterial glycan antigen lipoarabin[...]texto impreso
Castro-Sesquen, Yagahira E. ; Gilman, Robert H. ; Mejia, Carolina ; Clark, Daniel E. ; Choi, Jeong ; Reimer-McAtee, Melissa J. ; Castro, Rosario ; Valencia-Ayala, Edward ; Flores, Jorge ; Bowman, Natalie ; Castillo-Neyra, Ricardo ; Torrico, Faustino ; Liotta, Lance ; Bern, Caryn ; Luchini, Alessandra | Public Library of Science | 2019-02-06T14:45:11ZBACKGROUND: Early diagnosis of reactivated Chagas disease in HIV patients could be lifesaving. In Latin America, the diagnosis is made by microscopical detection of the T. cruzi parasite in the blood; a diagnostic test that lacks sensitivity. T[...]texto impreso
Castro-Sesquen, Yagahira E. ; Gilman, Robert H. ; Galdos-Cardenas, Gerson ; Ferrufino, Lisbeth ; Sanchez, Gerardo ; Valencia Ayala, Edward ; Liotta, Lance ; Bern, Caryn ; Luchini, Alessandra | Public Library of Science | 2020-06-10T18:12:17ZBACKGROUND: Detection of congenital T. cruzi transmission is considered one of the pillars of control programs of Chagas disease. Congenital transmission accounts for 25% of new infections with an estimated 15,000 infected infants per year. Cur[...]