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Título:
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A Controlled Study of Tuberculosis Diagnosis in HIV-Infected and Uninfected Children in Peru
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Autores:
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Oberhelman, Richard A. ;
Soto-Castellares, Giselle ;
Gilman, Robert H. ;
Castillo, Maria E. ;
Kolevic, Lenka ;
Delpino, Trinidad ;
Saito, Mayuko ;
Salazar-Lindo, Eduardo ;
Negron, Eduardo ;
Montenegro, Sonia ;
Laguna-Torres, V. Alberto ;
Maurtua-Neumann, Paola ;
Datta, Sumona ;
Evans, Carlton A.
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Tipo de documento:
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texto impreso
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Editorial:
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Public Library of Science, 2019-02-06T14:53:11Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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BACKGROUND: Diagnosing tuberculosis in children is challenging because specimens are difficult to obtain and contain low tuberculosis concentrations, especially with HIV-coinfection. Few studies included well-controls so test specificities are poorly defined. We studied tuberculosis diagnosis in 525 children with and without HIV-infection. METHODS AND FINDINGS: 'Cases' were children with suspected pulmonary tuberculosis (n = 209 HIV-negative; n = 81 HIV-positive) and asymptomatic 'well-control' children (n = 200 HIV-negative; n = 35 HIV-positive). Specimens (n = 2422) were gastric aspirates, nasopharyngeal aspirates and stools analyzed by a total of 9688 tests. All specimens were tested with an in-house hemi-nested IS6110 PCR that took 0.2) for
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En línea:
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http://doi.org/10.1371/journal.pone.0120915
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