Información del autor
Autor Zimic, Mirko |
Documentos disponibles escritos por este autor (38)
texto impreso
Adaui, Vanessa ; Lye, Lon-Fye ; Akopyants, Natalia S. ; Zimic, Mirko ; Llanos-Cuentas, Alejandro ; Garcia, Lineth ; Maes, Ilse ; De Doncker, Simonne ; Dobson, Deborah E. ; Arevalo, Jorge ; Dujardin, Jean-Claude ; Beverley, Stephen M. | Oxford University Press | 2019-02-06T14:57:40ZCutaneous and mucosal leishmaniasis, caused in South America by Leishmania braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [Sb(V)]). Treatment failure does not correlate well with resistance in vitro, and th[...]texto impreso
Correa, Malena ; Zimic, Mirko ; Barrientos, Franklin ; Barrientos, Ronald ; Roman-Gonzalez, Avid ; Pajuelo, Monica J. ; Anticona, Cynthia ; Mayta, Holger ; Alva, Alicia ; Solis-Vasquez, Leonardo ; Figueroa, Dante Anibal ; Chavez, Miguel A. ; Lavarello, Roberto ; Castañeda, Benjamin ; Paz-Soldan, Valerie A. ; Checkley, William ; Gilman, Robert H. ; Oberhelman, Richard | Public Library of Science | 2019-03-05T15:23:30ZPneumonia is one of the major causes of child mortality, yet with a timely diagnosis, it is usually curable with antibiotic therapy. In many developing regions, diagnosing pneumonia remains a challenge, due to shortages of medical resources. Lun[...]texto impreso
Lopez-Garnier, Santiago ; Sheen, Patricia ; Zimic, Mirko | Public Library of Science | 2019-07-04T16:59:21ZTuberculosis is an infectious disease that causes ill health and death in millions of people each year worldwide. Timely diagnosis and treatment is key to full patient recovery. The Microscopic Observed Drug Susceptibility (MODS) is a test to d[...]texto impreso
Lopez, Juan M. ; Antiparra, Ricardo ; Lippens, Guy ; Zimic, Mirko ; Sheen, Patricia ; Maruenda, Helena | Springer | 2018-11-30T02:09:30ZChagas disease is a trypanosomiasis disease inflicted by Trypanosoma cruzi parasite. In Latin America, at least 10 million people are infected and annually, 10,000 casualties are deplored. Macrophage infectivity potentiator protein is one of the[...]texto impreso
León-Janampa, Nancy ; Liendo, Ruddy ; Gilman, Robert H. ; Padilla, Carlos ; Garcia, Hector H. ; Gonzales, Armando ; Sheen, Patricia ; Pajuelo, Monica J. ; Zimic, Mirko ; Cysticercosis Working Group in Peru | Elsevier | 2019-07-04T16:59:24ZPorcine cysticercosis is an endemic parasitic disease caused by infection with Taenia solium that is found predominantly in developing countries. In order to aid in the development of simple diagnostic approaches, identification and characteriza[...]texto impreso
Tohma, Kentaro ; Saito, Mayuko ; Mayta, Holger ; Zimic, Mirko ; Lepore, Cara J. ; Ford-Siltz, Lauren A. ; Gilman, Robert H. ; Parra, Gabriel I. | American Society of Microbiology | 2018-11-30T02:09:31ZNorovirus, a leading cause of acute gastroenteritis in humans, is a highly diverse virus. Here, we report the complete genome sequence of a nontypeable genogroup II (GII) norovirus that was detected in a symptomatic Peruvian child in 2008. This [...]texto impreso
Grandjean, Louis ; Gilman, Robert H. ; Iwamoto, Tomatada ; Koser, Claudio U. ; Coronel, Jorge ; Zimic, Mirko ; Torok, M. Estee ; Ayabina, Diepreye ; Kendall, Michelle ; Fraser, Christophe ; Harris, Simon ; Parkhill, Julian ; Peacock, Sharon J. ; Moore, David A. J. ; Colijn, Caroline | Public Library of Science | 2019-01-25T15:02:21ZBACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic and preventive strat[...]texto impreso
Lee, Gwenyth O. ; Comina, Germán ; Hernández-Córdova, Gustavo ; Naik, Nehal ; Gayoso, Oscar ; Ticona, Eduardo ; Coronel, Jorge ; Evans, Carlton A. ; Zimic, Mirko ; Paz-Soldan, Valerie A. ; Gilman, Robert H. ; Oberhelman, Richard | Public Library of Science | 2020-07-14T00:02:31ZCough is a characteristic symptom of tuberculosis, is the main cause of transmission, and is used to assess treatment response. We aimed to identify the best measure of cough severity and characterize changes during initial tuberculosis therapy.[...]texto impreso
Valdivia-Olarte, Hugo ; Requena, David ; Ramírez, Manuel ; Saravia, Luis E. ; Izquierdo, Ray ; Falconi-Agapito, Francesca ; Zavaleta, Milagros ; Best, Ivan ; Fernandez-Diaz, Manolo ; Zimic, Mirko | Biomedical Informatics Publishing Group | 2019-02-06T14:52:14ZFowl adenoviruses (FAdVs) are the ethiologic agents of multiple pathologies in chicken. There are five different species of FAdVs grouped as FAdV-A, FAdV-B, FAdV-C, FAdV-D, and FAdV-E. It is of interest to develop immunodiagnostics and vaccine c[...]texto impreso
Dudley, Matthew Z. ; Sheen, Patricia ; Gilman, Robert H. ; Ticona, Eduardo ; Friedland, Jon S. ; Kirwan, Daniela E. ; Caviedes, Luz ; Rodriguez, Richard ; Cabrera, Lilia Z. ; Coronel, Jorge ; Grandjean, Louis ; Moore, David A. J. ; Evans, Carlton A. ; Huaroto, Luz ; Chavez-Perez, Victor ; Zimic, Mirko | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:12ZHospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA[...]texto impreso
Vargas-Cuentas, Natalia I. ; Roman-Gonzalez, Avid ; Gilman, Robert H. ; Barrientos, Franklin ; Ting, James ; Hidalgo, Daniela ; Jensen, Kelly ; Zimic, Mirko | Public Library of Science | 2019-01-25T15:18:33ZBACKGROUND: Autism spectrum disorder (ASD) currently affects nearly 1 in 160 children worldwide. In over two-thirds of evaluations, no validated diagnostics are used and gold standard diagnostic tools are used in less than 5% of evaluations. Cur[...]texto impreso
Alcántara, Roberto ; Fuentes, Patricia ; Marin, Lisette ; Kirwan, Daniela E. ; Gilman, Robert H. ; Zimic, Mirko ; Sheen, Patricia | American Society for Microbiology | 2020-07-14T00:00:54ZPyrazinamide (PZA) is considered the pivot drug in all tuberculosis treatment regimens, due to its particular action on the persistent forms of Mycobacterium tuberculosis. However, no drug susceptibility test (DST) is considered sufficiently rel[...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; López, José W. ; Lee, Gwenyth O. ; Bui, David ; Datta, Sumona ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Caviedes, Luz ; Cabrera, Jose L. ; Salas, Antonio ; Ticona, Eduardo ; Vu, Nancy M. ; Kirwan, Daniela E. ; Loader, Maria-Cristina I. ; Friedland, Jon S. ; Moore, David A. J. ; Evans, Carlton A. ; Tracey, Brian H. ; Gilman, Robert H. | Oxford University Press | 2019-01-25T16:59:37ZBackground: Cough is the major determinant of tuberculosis transmission. Despite this, there is a paucity of information regarding characteristics of cough frequency throughout the day and in response to tuberculosis therapy. Here we evaluate th[...]texto impreso
Garcia, Hector H. ; Gonzales, Isidro ; Lescano, Andres G. ; Bustos, Javier A. ; Zimic, Mirko ; Escalante, Diego ; Saavedra, Herbert ; Gavidia, Martin ; Rodriguez, Lourdes ; Najar, Enrique ; Umeres, Hugo ; Pretell, E. Javier | Elsevier | 2020-06-10T18:12:14ZBACKGROUND: Neurocysticercosis causes a substantial burden of seizure disorders worldwide. Treatment with either praziquantel or albendazole has suboptimum efficacy. We aimed to establish whether combination of these drugs would increase cystici[...]texto impreso
Rueda, Daniel ; Bernard, Christine ; Gandy, Lucas ; Capton, Estelle ; Boudjelloul, Rachid ; Brossier, Florence ; Veziris, Nicolas ; Zimic, Mirko ; Sougakoff, Wladimir | Medknow Publications | 2018-11-30T03:10:46ZBackground: The main mechanism of resistance to PZA in Mycobacterium tuberculosis relies on mutations on its pyrazinamidase/nicotinamidase. Recently, a rapid colorimetric test relying on the PCR-based in vitro-synthesized-PZase assay has been re[...]texto impreso
Solis, Leonardo ; Coronel, Jorge ; Rueda, Daniel ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Elsevier | 2019-02-06T14:57:42ZTuberculosis (TB) control efforts are hampered by a mismatch in diagnostic technology. Lack of adequate early diagnostics and Multi-drug resistant (MDR) detection is a critical problem in control efforts. Alternate and novel diagnostic approache[...]texto impreso
Pajuelo, Monica J. ; Eguiluz, María ; Roncal, Elisa ; Quiñones-García, Stefany ; Clipman, Steven J. ; Calcina, Juan ; Gavidia, Cesar M. ; Sheen, Patricia ; Garcia, Hector H. ; Gilman, Robert H. ; Gonzalez, Armando E. ; Zimic, Mirko ; Cysticercosis Working Group in Peru | Public Library of Science | 2019-01-25T15:18:36ZThe adult Taenia solium, the pork tapeworm, usually lives as a single worm in the small intestine of humans, its only known definitive host. Mechanisms of genetic variation in T. solium are poorly understood. Using three microsatellite markers p[...]texto impreso
Berthelot, Karine ; Estevez, Yannick ; Quiliano, Miguel ; Baldera-Aguayo, Pedro-A. ; Zimic, Mirko ; Pribat, Anne ; Bakleh, Marc-Elias ; Teyssier, Emeline ; Gallusci, Philippe ; Gardrat, Christian ; Lecomte, Sophie ; Peruch, Frederic | Elsevier | 2019-02-06T14:45:11ZIn this study, we cloned, expressed and purified the isopentenyl diphosphate isomerases (IDIs) from two plants, Hevea brasiliensis and Solanum lycopersicum, and compared them to the already well characterized Escherichia coli IDI. Phylogenetic a[...]texto impreso
Machicado, Claudia ; Marcos, Luis-A. ; Zimic, Mirko | Springer International Publishing | 2019-02-06T14:45:37ZFasciola hepatica is considered an emergent human pathogen, causing liver fibrosis or cirrhosis, conditions that are known to be direct causes of cancer. Some parasites have been categorized by WHO as carcinogenic agents such as Opisthorchis viv[...]texto impreso
Pajuelo, Monica J. ; Eguiluz, María ; Dahlstrom, Eric ; Requena, David ; Guzman, Frank ; Ramírez, Manuel ; Sheen, Patricia ; Frace, Michael ; Sammons, Scott ; Cama, Vitaliano ; Anzick, Sarah ; Bruno, Dan ; Mahanty, Siddhartha ; Wilkins, Patricia ; Nash, Theodore ; Gonzalez, Armando ; Garcia, Hector H. ; Gilman, Robert H. ; Porcella, Steve ; Zimic, Mirko | Public Library of Science | 2019-02-06T14:53:08ZBACKGROUND: Infections with Taenia solium are the most common cause of adult acquired seizures worldwide, and are the leading cause of epilepsy in developing countries. A better understanding of the genetic diversity of T. solium will improve p[...]texto impreso
Best, Ivan ; Privat-Maldonado, Angela ; Cruz, Maria ; Zimic, Mirko ; Bras-Gonçalves, Rachel ; Lemesre, Jean-Loup ; Arevalo, Jorge | Frontiers Media | 2018-10-10T23:27:56ZClinical manifestations of American Tegumentary Leishmaniasis (ATL) include cutaneous (CL) and mucous forms (ML); however, there are asymptomatic individuals who despite being infected do not present any clinical manifestations. This study chara[...]texto impreso
Cangalaya, Carla ; Zimic, Mirko ; Marzal, Miguel ; Gonzalez, Armando E. ; Guerra-Giraldez, Cristina ; Mahanty, Siddhartha ; Nash, Theodore E. ; Garcia, Hector H. | Public Library of Science | 2019-02-06T14:53:09ZBACKGROUND: Neurocysticercosis (NCC), infection of the central nervous system by Taenia solium cysticerci, is a pleomorphic disease. Inflammation around cysticerci is the major cause of disease but is variably present. One factor modulating the[...]texto impreso
Oberhelman, Richard A. ; Huaynate, Cynthia Anticona ; Correa, Malena ; Malpartida, Holger Mayta ; Pajuelo, Monica ; Paz-Soldan, Valerie A. ; Gilman, Robert H. ; Zimic, Mirko ; Murphy, Laura ; Belizan, Jose | American Society of Tropical Medicine and Hygiene | 2019-01-25T17:00:25ZPostdoctoral training programs are usually highly individualized arrangements between trainees and a limited number of senior mentors in their field, an approach that contrasts with current trends in public health education that promote interdis[...]texto impreso
Alva, Alicia ; Cangalaya, Carla ; Quiliano, Miguel ; Krebs, Casey ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Public Library of Science | 2019-01-25T15:28:05ZParasitic infections are generally diagnosed by professionals trained to recognize the morphological characteristics of the eggs in microscopic images of fecal smears. However, this laboratory diagnosis requires medical specialists which are lac[...]texto impreso
Salazar-Salinas, Karim ; Baldera-Aguayo, Pedro A. ; Encomendero-Risco, Jimy J. ; Orihuela, Melvin ; Sheen, Patricia ; Seminario, Jorge M. ; Zimic, Mirko | American Chemical Society | 2020-06-10T18:12:14ZMycobacterium tuberculosis pyrazinamidase (PZAse) is a key enzyme to activate the pro-drug pyrazinamide (PZA). PZAse is a metalloenzyme that coordinates in vitro different divalent metal cofactors in the metal coordination site (MCS). Several m[...]texto impreso
Alcántara, Roberto ; Fuentes, Patricia ; Antiparra, Ricardo ; Santos, Marco ; Gilman, Robert H. ; Kirwan, Daniela E. ; Zimic, Mirko ; Sheen, Patricia | American Society for Microbiology | 2018-11-30T17:17:15ZAlthough pyrazinamide (PZA) is a key component of first and second line tuberculosis treatment regimens, there is no gold standard to determine PZA resistance. Approximately 50% of multidrug-resistant tuberculosis (MDR-TB) and over 90% of extens[...]texto impreso
Ramirez-Salinas, Gema L. ; García-Machorro, J. ; Quiliano, Miguel ; Zimic, Mirko ; Briz, Veronica ; Rojas-Hernandez, Saul ; Correa-Basurto, J. | Springer | 2019-02-06T14:52:40ZThe goal of this study was to identify neuraminidase (NA) residue mutants from human influenza AH1N1 using sequences from 1918 to 2012. Multiple alignment studies of complete NA sequences (5732) were performed. Subsequently, the crystallographic[...]texto impreso
Sheen, Patricia ; Requena, David ; Gushiken, Eduardo ; Gilman, Robert H. ; Antiparra, Ricardo ; Lucero, Bryan ; Lizárraga, Pilar ; Cieza, Basilio ; Roncal, Elisa ; Grandjean, Louis ; Pain, Arnab ; McNerney, Ruth ; Clark, Taane G. ; Moore, David ; Zimic, Mirko | BMC | 2019-01-25T15:02:14ZBACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes. However, its comple[...]texto impreso
Saito, Mayuko ; Goel-Apaza, Sonia ; Espetia, Susan ; Velasquez, Daniel ; Cabrera, Lilia ; Loli, Sebastian ; Crabtree, Jean E. ; Black, Robert E. ; Kosek, Margaret ; Checkley, William ; Zimic, Mirko ; Bern, Caryn ; Cama, Vitaliano ; Gilman, Robert H. | Oxford University Press | 2020-06-10T18:11:32ZBACKGROUND: Human noroviruses are among the most common enteropathogens globally, and are a leading cause of infant diarrhea in developing countries. However, data measuring the impact of norovirus at the community level are sparse. METHODS: We [...]texto impreso
Ponce, Reynaldo ; León-Janampa, Nancy ; Gilman, Robert H. ; Liendo, Ruddy ; Roncal, Elisa ; Luis, Sueline ; Quiñones-García, Stefany ; Silverstein, Zach ; Garcia, Hector H. ; Gonzales, Armando ; Sheen, Patricia ; Zimic, Mirko ; Pajuelo, Monica J. ; Cysticercosis Working Group in Peru | Elsevier | 2018-11-30T02:09:28ZCysticercosis is a worldwide parasitic disease of humans and pigs principally caused by infection with the larvae of the pork tapeworm Taenia solium. Through the use of the recently-made-available T. solium genome, we identified a gene within a [...]texto impreso
Rueda, Daniel ; Furukawa, Roberto ; Fuentes, Patricia ; Comina, Germán ; Rey De Castro, Nicolás G. ; Requena, David ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Medknow Publications | 2018-11-30T02:09:28ZIntroduction: Tuberculosis (TB) is a significant cause of morbidity and mortality worldwide. The patient compliance with the long treatment regimens is essential for successful eradication. Pyrazinamide (PZA) shortens these regimens from 9 to 6 [...]texto impreso
Castro, Juan C. ; Maddox, J. Dylan ; Cobos, Marianela ; Requena, David ; Zimic, Mirko ; Bombarely, Aureliano ; Iman, Sixto A. ; Cerdeira, Luis A. ; Medina, Andersson E. | BMC | 2019-02-06T14:52:14ZBackground. Myrciaria dubia is an Amazonian fruit shrub that produces numerous bioactive phytochemicals, but is best known by its high L-ascorbic acid (AsA) content in fruits. Pronounced variation in AsA content has been observed both within and[...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; Tracey, Brian H. ; López, José W. ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Lee, Gwenyth O'Neil ; Caviedes, Luz ; Cabrera, Jose Luis ; Salas, Antonio ; Ticona, Eduardo ; Kirwan, Daniela E. ; Friedland, Jon S. ; Evans, Carlton A. ; Moore, David A. ; Gilman, Robert H. | BMJ Publishing Group | 2019-02-06T14:51:43ZINTRODUCTION: Cough is a key symptom of tuberculosis (TB) as well as the main cause of transmission. However, a recent literature review found that cough frequency (number of coughs per hour) in patients with TB has only been studied once, in 19[...]texto impreso
Meinzen, Christopher ; Proaño, Alvaro ; Gilman, Robert H. ; Caviedes, Luz ; Coronel, Jorge ; Zimic, Mirko ; Sheen, Patricia | Elsevier | 2019-02-06T14:45:55ZBACKGROUND: Pyrazinamide (PZA) is the most important drug against the latent stage of tuberculosis (TB) and is used in both first and second line treatment regimens. The continued increase in multi-drug resistant TB and the prevalence of PZA res[...]texto impreso
Gonzalez, Armando E. ; Bustos, Javier A. ; Garcia, Hector H. ; Rodriguez, Silvia ; Zimic, Mirko ; Castillo, Yesenia ; Praet, Nicolas ; Gabriel, Sarah ; Gilman, Robert H. ; Dorny, Pierre | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:38ZTaenia solium cysticercosis is a common parasitic infection of humans and pigs. We evaluated the posttreatment evolution of circulating parasite-specific antigen titers in 693 consecutive blood samples from 50 naturally infected cysticercotic p[...]texto impreso
León-Janampa, Nancy ; Zimic, Mirko ; Shinkaruk, Svitlana ; Quispe-Marcatoma, J. ; Gutarra, Abel ; Le Bourdon, Gwénaëlle ; Gayot, Marion ; Changanaqui, Katherina ; Gilman, Robert H. ; Fouquet, Eric ; Sheen, Patricia ; Szlosek, Magali | IOP Publishing | 2020-07-14T00:02:31ZMycobacterium tuberculosis is the cause of one of the diseases with the highest mortality and morbidity rate in the Americas and in the world. In developing countries, the diagnosis of tuberculosis (TB) is based on baciloscopy and bacteriologica[...]texto impreso
Grandjean, Louis ; Iwamoto, Tomotada ; Lithgow, Anna ; Gilman, Robert H. ; Arikawa, Kentaro ; Nakanishi, Noriko ; Martin, Laura ; Castillo, Edith ; Alarcon, Valentina ; Coronel, Jorge ; Solano, Walter ; Aminian, Minoo ; Guezala, Claudia ; Rastogi, Nalin ; Couvin, David ; Sheen, Patricia ; Zimic, Mirko ; Moore, David A. J. | Public Library of Science | 2019-02-06T14:53:10ZBACKGROUND: The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the sprea[...]texto impreso
Knight, Gwenan M. ; Zimic, Mirko ; Funk, Sebastian ; Gilman, Robert H. ; Friedland, Jon S. ; Grandjean, Louis | The Royal Society | 2018-11-30T23:41:30ZThe relative fitness of drug-resistant versus susceptible bacteria in an environment dictates resistance prevalence. Estimates for the relative fitness of resistant Mycobacterium tuberculosis (Mtb) strains are highly heterogeneous and mostly der[...]