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Adaui, Vanessa ; Lye, Lon-Fye ; Akopyants, Natalia S. ; Zimic, Mirko ; Llanos-Cuentas, Alejandro ; Garcia, Lineth ; Maes, Ilse ; De Doncker, Simonne ; Dobson, Deborah E. ; Arevalo, Jorge ; Dujardin, Jean-Claude ; Beverley, Stephen M. | Oxford University Press | 2019-02-06T14:57:40ZCutaneous and mucosal leishmaniasis, caused in South America by Leishmania braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [Sb(V)]). Treatment failure does not correlate well with resistance in vitro, and th[...]texto impreso
Correa, Malena ; Zimic, Mirko ; Barrientos, Franklin ; Barrientos, Ronald ; Roman-Gonzalez, Avid ; Pajuelo, Monica J. ; Anticona, Cynthia ; Mayta, Holger ; Alva, Alicia ; Solis-Vasquez, Leonardo ; Figueroa, Dante Anibal ; Chavez, Miguel A. ; Lavarello, Roberto ; Castañeda, Benjamin ; Paz-Soldan, Valerie A. ; Checkley, William ; Gilman, Robert H. ; Oberhelman, Richard | Public Library of Science | 2019-03-05T15:23:30ZPneumonia is one of the major causes of child mortality, yet with a timely diagnosis, it is usually curable with antibiotic therapy. In many developing regions, diagnosing pneumonia remains a challenge, due to shortages of medical resources. Lun[...]texto impreso
Lopez-Garnier, Santiago ; Sheen, Patricia ; Zimic, Mirko | Public Library of Science | 2019-07-04T16:59:21ZTuberculosis is an infectious disease that causes ill health and death in millions of people each year worldwide. Timely diagnosis and treatment is key to full patient recovery. The Microscopic Observed Drug Susceptibility (MODS) is a test to d[...]texto impreso
Lopez, Juan M. ; Antiparra, Ricardo ; Lippens, Guy ; Zimic, Mirko ; Sheen, Patricia ; Maruenda, Helena | Springer | 2018-11-30T02:09:30ZChagas disease is a trypanosomiasis disease inflicted by Trypanosoma cruzi parasite. In Latin America, at least 10 million people are infected and annually, 10,000 casualties are deplored. Macrophage infectivity potentiator protein is one of the[...]texto impreso
León-Janampa, Nancy ; Liendo, Ruddy ; Gilman, Robert H. ; Padilla, Carlos ; Garcia, Hector H. ; Gonzales, Armando ; Sheen, Patricia ; Pajuelo, Monica J. ; Zimic, Mirko ; Cysticercosis Working Group in Peru | Elsevier | 2019-07-04T16:59:24ZPorcine cysticercosis is an endemic parasitic disease caused by infection with Taenia solium that is found predominantly in developing countries. In order to aid in the development of simple diagnostic approaches, identification and characteriza[...]texto impreso
Tohma, Kentaro ; Saito, Mayuko ; Mayta, Holger ; Zimic, Mirko ; Lepore, Cara J. ; Ford-Siltz, Lauren A. ; Gilman, Robert H. ; Parra, Gabriel I. | American Society of Microbiology | 2018-11-30T02:09:31ZNorovirus, a leading cause of acute gastroenteritis in humans, is a highly diverse virus. Here, we report the complete genome sequence of a nontypeable genogroup II (GII) norovirus that was detected in a symptomatic Peruvian child in 2008. This [...]texto impreso
Grandjean, Louis ; Gilman, Robert H. ; Iwamoto, Tomatada ; Koser, Claudio U. ; Coronel, Jorge ; Zimic, Mirko ; Torok, M. Estee ; Ayabina, Diepreye ; Kendall, Michelle ; Fraser, Christophe ; Harris, Simon ; Parkhill, Julian ; Peacock, Sharon J. ; Moore, David A. J. ; Colijn, Caroline | Public Library of Science | 2019-01-25T15:02:21ZBACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic and preventive strat[...]texto impreso
Lee, Gwenyth O. ; Comina, Germán ; Hernández-Córdova, Gustavo ; Naik, Nehal ; Gayoso, Oscar ; Ticona, Eduardo ; Coronel, Jorge ; Evans, Carlton A. ; Zimic, Mirko ; Paz-Soldan, Valerie A. ; Gilman, Robert H. ; Oberhelman, Richard | Public Library of Science | 2020-07-14T00:02:31ZCough is a characteristic symptom of tuberculosis, is the main cause of transmission, and is used to assess treatment response. We aimed to identify the best measure of cough severity and characterize changes during initial tuberculosis therapy.[...]texto impreso
Valdivia-Olarte, Hugo ; Requena, David ; Ramírez, Manuel ; Saravia, Luis E. ; Izquierdo, Ray ; Falconi-Agapito, Francesca ; Zavaleta, Milagros ; Best, Ivan ; Fernandez-Diaz, Manolo ; Zimic, Mirko | Biomedical Informatics Publishing Group | 2019-02-06T14:52:14ZFowl adenoviruses (FAdVs) are the ethiologic agents of multiple pathologies in chicken. There are five different species of FAdVs grouped as FAdV-A, FAdV-B, FAdV-C, FAdV-D, and FAdV-E. It is of interest to develop immunodiagnostics and vaccine c[...]texto impreso
Dudley, Matthew Z. ; Sheen, Patricia ; Gilman, Robert H. ; Ticona, Eduardo ; Friedland, Jon S. ; Kirwan, Daniela E. ; Caviedes, Luz ; Rodriguez, Richard ; Cabrera, Lilia Z. ; Coronel, Jorge ; Grandjean, Louis ; Moore, David A. J. ; Evans, Carlton A. ; Huaroto, Luz ; Chavez-Perez, Victor ; Zimic, Mirko | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:12ZHospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA[...]texto impreso
Vargas-Cuentas, Natalia I. ; Roman-Gonzalez, Avid ; Gilman, Robert H. ; Barrientos, Franklin ; Ting, James ; Hidalgo, Daniela ; Jensen, Kelly ; Zimic, Mirko | Public Library of Science | 2019-01-25T15:18:33ZBACKGROUND: Autism spectrum disorder (ASD) currently affects nearly 1 in 160 children worldwide. In over two-thirds of evaluations, no validated diagnostics are used and gold standard diagnostic tools are used in less than 5% of evaluations. Cur[...]texto impreso
Alcántara, Roberto ; Fuentes, Patricia ; Marin, Lisette ; Kirwan, Daniela E. ; Gilman, Robert H. ; Zimic, Mirko ; Sheen, Patricia | American Society for Microbiology | 2020-07-14T00:00:54ZPyrazinamide (PZA) is considered the pivot drug in all tuberculosis treatment regimens, due to its particular action on the persistent forms of Mycobacterium tuberculosis. However, no drug susceptibility test (DST) is considered sufficiently rel[...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; López, José W. ; Lee, Gwenyth O. ; Bui, David ; Datta, Sumona ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Caviedes, Luz ; Cabrera, Jose L. ; Salas, Antonio ; Ticona, Eduardo ; Vu, Nancy M. ; Kirwan, Daniela E. ; Loader, Maria-Cristina I. ; Friedland, Jon S. ; Moore, David A. J. ; Evans, Carlton A. ; Tracey, Brian H. ; Gilman, Robert H. | Oxford University Press | 2019-01-25T16:59:37ZBackground: Cough is the major determinant of tuberculosis transmission. Despite this, there is a paucity of information regarding characteristics of cough frequency throughout the day and in response to tuberculosis therapy. Here we evaluate th[...]texto impreso
Garcia, Hector H. ; Gonzales, Isidro ; Lescano, Andres G. ; Bustos, Javier A. ; Zimic, Mirko ; Escalante, Diego ; Saavedra, Herbert ; Gavidia, Martin ; Rodriguez, Lourdes ; Najar, Enrique ; Umeres, Hugo ; Pretell, E. Javier | Elsevier | 2020-06-10T18:12:14ZBACKGROUND: Neurocysticercosis causes a substantial burden of seizure disorders worldwide. Treatment with either praziquantel or albendazole has suboptimum efficacy. We aimed to establish whether combination of these drugs would increase cystici[...]texto impreso
Rueda, Daniel ; Bernard, Christine ; Gandy, Lucas ; Capton, Estelle ; Boudjelloul, Rachid ; Brossier, Florence ; Veziris, Nicolas ; Zimic, Mirko ; Sougakoff, Wladimir | Medknow Publications | 2018-11-30T03:10:46ZBackground: The main mechanism of resistance to PZA in Mycobacterium tuberculosis relies on mutations on its pyrazinamidase/nicotinamidase. Recently, a rapid colorimetric test relying on the PCR-based in vitro-synthesized-PZase assay has been re[...]
