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Autor Zimic, Mirko |
Documentos disponibles escritos por este autor (38)
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Alcántara, Roberto ; Fuentes, Patricia ; Antiparra, Ricardo ; Santos, Marco ; Gilman, Robert H. ; Kirwan, Daniela E. ; Zimic, Mirko ; Sheen, Patricia | American Society for Microbiology | 2018-11-30T17:17:15ZAlthough pyrazinamide (PZA) is a key component of first and second line tuberculosis treatment regimens, there is no gold standard to determine PZA resistance. Approximately 50% of multidrug-resistant tuberculosis (MDR-TB) and over 90% of extens[...]![]()
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Ramirez-Salinas, Gema L. ; García-Machorro, J. ; Quiliano, Miguel ; Zimic, Mirko ; Briz, Veronica ; Rojas-Hernandez, Saul ; Correa-Basurto, J. | Springer | 2019-02-06T14:52:40ZThe goal of this study was to identify neuraminidase (NA) residue mutants from human influenza AH1N1 using sequences from 1918 to 2012. Multiple alignment studies of complete NA sequences (5732) were performed. Subsequently, the crystallographic[...]![]()
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Sheen, Patricia ; Requena, David ; Gushiken, Eduardo ; Gilman, Robert H. ; Antiparra, Ricardo ; Lucero, Bryan ; Lizárraga, Pilar ; Cieza, Basilio ; Roncal, Elisa ; Grandjean, Louis ; Pain, Arnab ; McNerney, Ruth ; Clark, Taane G. ; Moore, David ; Zimic, Mirko | BMC | 2019-01-25T15:02:14ZBACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment regimes. However, its comple[...]![]()
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Saito, Mayuko ; Goel-Apaza, Sonia ; Espetia, Susan ; Velasquez, Daniel ; Cabrera, Lilia ; Loli, Sebastian ; Crabtree, Jean E. ; Black, Robert E. ; Kosek, Margaret ; Checkley, William ; Zimic, Mirko ; Bern, Caryn ; Cama, Vitaliano ; Gilman, Robert H. | Oxford University Press | 2020-06-10T18:11:32ZBACKGROUND: Human noroviruses are among the most common enteropathogens globally, and are a leading cause of infant diarrhea in developing countries. However, data measuring the impact of norovirus at the community level are sparse. METHODS: We [...]![]()
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Ponce, Reynaldo ; León-Janampa, Nancy ; Gilman, Robert H. ; Liendo, Ruddy ; Roncal, Elisa ; Luis, Sueline ; Quiñones-García, Stefany ; Silverstein, Zach ; Garcia, Hector H. ; Gonzales, Armando ; Sheen, Patricia ; Zimic, Mirko ; Pajuelo, Monica J. ; Cysticercosis Working Group in Peru | Elsevier | 2018-11-30T02:09:28ZCysticercosis is a worldwide parasitic disease of humans and pigs principally caused by infection with the larvae of the pork tapeworm Taenia solium. Through the use of the recently-made-available T. solium genome, we identified a gene within a [...]![]()
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Rueda, Daniel ; Furukawa, Roberto ; Fuentes, Patricia ; Comina, Germán ; Rey De Castro, Nicolás G. ; Requena, David ; Gilman, Robert H. ; Sheen, Patricia ; Zimic, Mirko | Medknow Publications | 2018-11-30T02:09:28ZIntroduction: Tuberculosis (TB) is a significant cause of morbidity and mortality worldwide. The patient compliance with the long treatment regimens is essential for successful eradication. Pyrazinamide (PZA) shortens these regimens from 9 to 6 [...]![]()
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Castro, Juan C. ; Maddox, J. Dylan ; Cobos, Marianela ; Requena, David ; Zimic, Mirko ; Bombarely, Aureliano ; Iman, Sixto A. ; Cerdeira, Luis A. ; Medina, Andersson E. | BMC | 2019-02-06T14:52:14ZBackground. Myrciaria dubia is an Amazonian fruit shrub that produces numerous bioactive phytochemicals, but is best known by its high L-ascorbic acid (AsA) content in fruits. Pronounced variation in AsA content has been observed both within and[...]![]()
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Proaño, Alvaro ; Bravard, Marjory A. ; Tracey, Brian H. ; López, José W. ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Lee, Gwenyth O'Neil ; Caviedes, Luz ; Cabrera, Jose Luis ; Salas, Antonio ; Ticona, Eduardo ; Kirwan, Daniela E. ; Friedland, Jon S. ; Evans, Carlton A. ; Moore, David A. ; Gilman, Robert H. | BMJ Publishing Group | 2019-02-06T14:51:43ZINTRODUCTION: Cough is a key symptom of tuberculosis (TB) as well as the main cause of transmission. However, a recent literature review found that cough frequency (number of coughs per hour) in patients with TB has only been studied once, in 19[...]![]()
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Meinzen, Christopher ; Proaño, Alvaro ; Gilman, Robert H. ; Caviedes, Luz ; Coronel, Jorge ; Zimic, Mirko ; Sheen, Patricia | Elsevier | 2019-02-06T14:45:55ZBACKGROUND: Pyrazinamide (PZA) is the most important drug against the latent stage of tuberculosis (TB) and is used in both first and second line treatment regimens. The continued increase in multi-drug resistant TB and the prevalence of PZA res[...]![]()
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Gonzalez, Armando E. ; Bustos, Javier A. ; Garcia, Hector H. ; Rodriguez, Silvia ; Zimic, Mirko ; Castillo, Yesenia ; Praet, Nicolas ; Gabriel, Sarah ; Gilman, Robert H. ; Dorny, Pierre | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:38ZTaenia solium cysticercosis is a common parasitic infection of humans and pigs. We evaluated the posttreatment evolution of circulating parasite-specific antigen titers in 693 consecutive blood samples from 50 naturally infected cysticercotic p[...]![]()
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León-Janampa, Nancy ; Zimic, Mirko ; Shinkaruk, Svitlana ; Quispe-Marcatoma, J. ; Gutarra, Abel ; Le Bourdon, Gwénaëlle ; Gayot, Marion ; Changanaqui, Katherina ; Gilman, Robert H. ; Fouquet, Eric ; Sheen, Patricia ; Szlosek, Magali | IOP Publishing | 2020-07-14T00:02:31ZMycobacterium tuberculosis is the cause of one of the diseases with the highest mortality and morbidity rate in the Americas and in the world. In developing countries, the diagnosis of tuberculosis (TB) is based on baciloscopy and bacteriologica[...]![]()
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Grandjean, Louis ; Iwamoto, Tomotada ; Lithgow, Anna ; Gilman, Robert H. ; Arikawa, Kentaro ; Nakanishi, Noriko ; Martin, Laura ; Castillo, Edith ; Alarcon, Valentina ; Coronel, Jorge ; Solano, Walter ; Aminian, Minoo ; Guezala, Claudia ; Rastogi, Nalin ; Couvin, David ; Sheen, Patricia ; Zimic, Mirko ; Moore, David A. J. | Public Library of Science | 2019-02-06T14:53:10ZBACKGROUND: The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the sprea[...]![]()
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Knight, Gwenan M. ; Zimic, Mirko ; Funk, Sebastian ; Gilman, Robert H. ; Friedland, Jon S. ; Grandjean, Louis | The Royal Society | 2018-11-30T23:41:30ZThe relative fitness of drug-resistant versus susceptible bacteria in an environment dictates resistance prevalence. Estimates for the relative fitness of resistant Mycobacterium tuberculosis (Mtb) strains are highly heterogeneous and mostly der[...]