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Adequate acclimatization time to enable adjustment to hypoxic conditions is one of the most important aspects for mountaineers ascending to high altitude. Accordingly, most reviews emphasize mechanisms that cope with reduced oxygen supply. Howev[...]texto impreso
Ostergaard, Louise ; Rudiger, Alain ; Wellmann, Sven ; Gammella, Elena ; Beck-Schimmer, Beatrice ; Struck, Joachim ; Maggiorini, Marco ; Gassmann, Max | Dove Medical Press | 2020-06-10T18:11:29ZBACKGROUND: A reduced oxygen supply puts patients at risk of tissue hypoxia, organ damage, and even death. In response, several changes are activated that allow for at least partial adaptation, thereby increasing the chances of survival. We aime[...]texto impreso
Díaz, Victor ; Peinado, Ana B. ; Barba-Moreno, Laura ; Altamura, Sandro ; Butragueno, Javier ; González-Gross, Marcela ; Alteheld, Birgit ; Stehle, Peter ; Zapico, Augusto G. ; Muckenthaler, Martina U. ; Gassmann, Max | Wiley Open Access | 2019-02-06T14:53:08ZIron deficiency among endurance athletes is of major concern for coaches, physicians, and nutritionists. Recently, it has been observed that hepcidin, the master regulator of iron metabolism, was upregulated after exercise and was found to be r[...]texto impreso
Gammella, Elena ; Díaz, Victor ; Recalcati, Stefania ; Buratti, Paolo ; Samaja, Michele ; Dey, Soumyadeep ; Noguchi, Constance Tom ; Gassmann, Max ; Cairo, Gaetano | American Physiological Society | 2019-02-06T14:52:12ZUnder conditions of accelerated erythropoiesis, elevated erythropoietin (Epo) levels are associated with inhibition of hepcidin synthesis, a response that ultimately increases iron availability to meet the enhanced iron needs of erythropoietic c[...]texto impreso
Gammella, Elena ; Díaz, Victor ; Recalcati, Stefania ; Buratti, Paolo ; Samaja, Michele ; Dey, Soumyadeep ; Noguchi, Constance Tom ; Gassmann, Max ; Cairo, Gaetano | American Physiological Society | 2020-06-10T18:11:33ZUnder conditions of accelerated erythropoiesis, elevated erythropoietin (Epo) levels are associated with inhibition of hepcidin synthesis, a response that ultimately increases iron availability to meet the enhanced iron needs of erythropoietic c[...]texto impreso
Singh, Rashim Pal ; Grinenko, Tatyana ; Ramasz, Beáta ; Franke, Kristin ; Lesche, Mathias ; Dahl, Andreas ; Gassmann, Max ; Chavakis, Triantafyllos ; Henry, Ian ; Wielockx, Ben | Elsevier | 2018-11-30T17:17:12ZThe hematopoietic stem cell (HSC) compartment consists of a small pool of cells capable of replenishing all blood cells. Although it is established that the hematopoietic system is assembled as a hierarchical organization under steady-state cond[...]texto impreso
Koester-Hegmann, Christina ; Bengoetxea, Harkaitz ; Kosenkov, Dmitry ; Thiersch, Markus ; Haider, Thomas ; Gassmann, Max ; Schneider Gasser, Edith M. | Frontiers Media | 2019-07-04T17:00:15ZExposure to hypobaric hypoxia at high altitude (above 2500 m asl) causes cognitive impairment, mostly attributed to changes in brain perfusion and consequently neuronal death. Enriched environment and voluntary exercise has been shown to improve[...]texto impreso
Laouafa, Sofien ; Elliot-Portal, Elizabeth ; Revollo, Susana ; Schneider-Gasser, Edith-M. ; Joseph, Vincent ; Voituron, Nicolas ; Gassmann, Max ; Soliz, Jorge | American Physiological Society | 2019-02-06T14:45:36ZThe impact of cerebral erythropoietin (Epo) in the regulation of the hypercapnic ventilatory response (HcVR) is controversial. While we reported that cerebral Epo does not affect the central chemosensitivity in C57Bl6 mice receiving an intracis[...]texto impreso
Rauner, Martina ; Franke, Kristin ; Murray, Marta ; Singh, Rashim-Pal ; Hiram-Bab, Sahar ; Platzbecker, Uwe ; Gassmann, Max ; Socolovsky, Merav ; Neumann, Drorit ; Gabet, Yankel ; Chavakis, Triantafyllos ; Hofbauer, Lorenz-C. ; Wielockx, Ben | American Society for Bone and Mineral Research | 2019-02-06T14:45:58ZThe main oxygen sensor hypoxia inducible factor (HIF) prolyl hydroxylase 2 (PHD2) is a critical regulator of tissue homeostasis during erythropoiesis, hematopoietic stem cell maintenance, and wound healing. Recent studies point toward a role for[...]texto impreso
Monge Naldi, Arianne ; Belfrage, Celina ; Jain, Neha ; Wei, Eric T. ; Canto Martorell, Belen ; Gassmann, Max ; Vogel, Johannes | Elsevier | 2019-02-06T14:53:07ZSo far, typical causes of presbycusis such as degeneration of hair cells and/or primary auditory (spiral ganglion) neurons cannot be treated. Because erythropoietin's (Epo) neuroprotective potential has been shown previously, we determined heari[...]texto impreso
Gassmann, Norina-N. ; van-Elteren, Hugo-A. ; Goos, Tom-G. ; Morales, Claudia-R. ; Rivera-Ch, Maria ; Martin, Daniel-S. ; Cabala-Peralta, Patricia ; Passano-Del-Carpio, Agustin ; Aranibar-Machaca, Saul ; Huicho, Luis ; Reiss, Irwin-K. M. ; Gassmann, Max ; de-Jonge, Rogier-C. J. | American Physiological Society | 2019-02-06T14:45:34ZThe developing human fetus is able to cope with the physiological reduction in oxygen supply occurring in utero. However, it is not known if microvascularization of the fetus is augmented when pregnancy occurs at high altitude. Fifty-three healt[...]texto impreso
Vavricka, Stephan ; Ruiz, Pedro A. ; Scharl, Sylvie ; Biedermann, Luc ; Scharl, Michael ; de Valliere, Cheryl ; Lundby, Carsten ; Wenger, Roland H. ; Held, Leonhard ; Merz, Tobias M. ; Gassmann, Max ; Lutz, Thomas ; Kunz, Andres ; Bron, Denis ; Fontana, Adriano ; Strauss, Laura ; Weber, Achim ; Fried, Michael ; Rogler, Gerhard ; Zeitz, Jonas | BMJ Publishing Group | 2019-01-25T17:00:27ZINTRODUCTION: Inflammatory bowel disease (IBD) is a chronic intestinal disorder, often leading to an impaired quality of life in affected patients. The importance of environmental factors in the pathogenesis of IBD, including their disease-modif[...]texto impreso
Dey, Soumyadeep ; Cui, Zhenzhong ; Gavrilova, Oksana ; Zhang, Xiaojie ; Gassmann, Max ; Noguchi, Constance T. | American Society for Clinical Investigation | 2020-07-14T00:01:08ZThe blood hormone erythropoietin (EPO), upon binding to its receptor (EpoR), modulates high-fat diet-induced (HFO-induced) obesity in mice, improves glucose tolerance, and prevents white adipose tissue inflammation. Transgenic mice with constitu[...]texto impreso
Gassmann, Max ; Mairbaurl, Heimo ; Livshits, Leonid ; Seide, Svenja ; Hackbusch, Matthes ; Malczyk, Monika ; Kraut, Simone ; Gassmann, Norina N. ; Weissmann, Norbert ; Muckenthaler, Martina U. | Wiley | 2019-12-06T21:02:58ZDecreased oxygen availability at high altitude requires physiological adjustments allowing for adequate tissue oxygenation. One such mechanism is a slow increase in the hemoglobin concentration ([Hb]) resulting in elevated [Hb] in high-altitude [...]texto impreso
Gassmann, Max ; Mairbaurl, Heimo ; Livshits, Leonid ; Seide, Svenja ; Hackbusch, Matthes ; Malczyk, Monika ; Kraut, Simone ; Gassmann, Norina N. ; Weissmann, Norbert ; Muckenthaler, Martina U. | Wiley | 2019-08-08T15:23:44ZDecreased oxygen availability at high altitude requires physiological adjustments allowing for adequate tissue oxygenation. One such mechanism is a slow increase in the hemoglobin concentration ([Hb]) resulting in elevated [Hb] in high-altitude [...]
