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Arroyo, Gianfranco ; Bustos, Javier A. ; Lescano, Andres G. ; Gonzales, Isidro ; Saavedra, Herbert ; Rodriguez, Silvia ; Pretell, E. Javier ; Bonato, Pierina S. ; Lanchote, Vera L. ; Takayanagui, Osvaldo M. ; Horton, John ; Gonzalez, Armando E. ; Gilman, Robert H. ; Garcia, Hector H. | Oxford University Press | 2019-07-04T16:59:18ZBackground: Albendazole is the drug of choice for the treatment of parenchymal neurocysticercosis, although its efficacy is suboptimal. Plasma levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable amon[...]texto impreso
Arroyo, Gianfranco ; Bustos, Javier A. ; Lescano, Andres G. ; Gonzales, Isidro ; Saavedra, Herbert ; Rodriguez, Silvia ; Pretell, E. Javier ; Bonato, Pierina S. ; Lanchote, Vera L. ; Takayanagui, Osvaldo M. ; Horton, John ; Gonzalez, Armando E. ; Gilman, Robert H. ; Garcia, Hector H. | Oxford University Press | 2019-12-06T21:02:55ZBACKGROUND: The efficacy of albendazole therapy in patients with parenchymal neurocysticercosis (NCC) is suboptimal. Plasma levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable among patients. We hypo[...]texto impreso
Arroyo, Gianfranco ; Rodriguez, Silvia ; Lescano, Andres G. ; Alroy, Karen A. ; Bustos, Javier A. ; Santivañez, Saul ; Gonzales, Isidro ; Saavedra, Herbert ; Pretell, E. Javier ; Gonzalez, Armando E. ; Gilman, Robert H. ; Tsang, Victor C. W. ; Garcia, Hector H. ; Cysticercosis Working Group in Peru | Oxford University Press | 2018-11-30T02:09:29ZBackground: The enzyme-linked immunoelectrotransfer blot (EITB) assay is the reference serological test for neurocysticercosis (NCC). A positive result on EITB does not always correlate with the presence of active infections in the central nervo[...]texto impreso
Alroy, Karen A. ; Arroyo, Gianfranco ; Gilman, Robert H. ; Gonzales-Gustavson, Eloy ; Gallegos, Linda ; Gavidia, Cesar M. ; Verastegui, Manuela ; Rodriguez, Silvia ; López, Teresa ; Gomez-Puerta, Luis A. ; Alroy, Joseph ; Garcia, Hector H. ; Gonzalez, Armando E. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2018-11-30T02:09:30ZNeurocysticercosis (NCC), the infection of the human central nervous system (CNS) with larval cysts of Taenia solium causes widespread neurological morbidity. Animal models are crucial for studying the pathophysiology and treatment of NCC. Some [...]texto impreso
Bustos, Javier A. ; Arroyo, Gianfranco ; Gilman, Robert H. ; Soto-Becerra, Percy ; Gonzales, Isidro ; Saavedra, Herbert ; Pretell, E. Javier ; Nash, Theodore E. ; O'Neal, Seth E. ; Del Brutto, Oscar H. ; Gonzalez, Armando E. ; Garcia, Hector H. ; Cysticercosis Working Group in Peru | Oxford University Press | 2020-07-14T00:00:59ZBACKGROUND: Neurocysticercosis (NCC) is a major cause of acquired epilepsy in most of the world. Larval cysts in the human brain eventually resolve and either disappear or leave a calcified scar that is associated with seizures. This study asses[...]texto impreso
Carrera, Jean-Paul ; Bagamian, Karoun H. ; Travassos da Rosa, Amelia P. ; Wang, Eryu ; Beltran, Davis ; Gundaker, Nathan D. ; Armien, Blas ; Arroyo, Gianfranco ; Sosa, Néstor ; Pascale, Juan Miguel ; Valderrama, Anayansi ; Tesh, Robert B. ; Vittor, Amy Y. ; Weaver, Scott C. | American Society of Tropical Medicine and Hygiene | 2018-11-30T17:17:13ZMembers of the genera Alphavirus (family Togaviridae) and Flavivirus (family Flaviridae) are important zoonotic human and equine etiologic agents of neurologic diseases in the New World. In 2010, an outbreak of Madariaga virus (MADV; formerly ea[...]texto impreso
Mahanty, Siddhartha ; Orrego, Miguel Angel ; Mayta, Holger ; Marzal, Miguel ; Cangalaya, Carla ; Paredes, Adriana ; Gonzales-Gustavson, Eloy ; Arroyo, Gianfranco ; Gonzalez, Armando E. ; Guerra-Giraldez, Cristina ; Garcia, Hector H. ; Nash, Theodore E. | Public Library of Science | 2019-02-06T14:53:10ZCysticidal treatment of neurocysticercosis, an infection of humans and pig brains with Taenia solium, results in an early inflammatory response directed to cysts causing seizures and focal neurological manifestations. Treatment-induced pericysti[...]texto impreso
Cangalaya, Carla ; Bustos, Javier A. ; Calcina, Juan ; Vargas-Calla, Ana ; Mamani, Javier ; Suarez, Diego ; Arroyo, Gianfranco ; Gonzalez, Armando E. ; Chacaltana, Juan ; Guerra-Giraldez, Cristina ; Mahanty, Siddhartha ; Nash, Theodore E. ; Garcia, Hector H. | Public Library of Science | 2019-01-25T16:03:19ZBACKGROUND: The onset of anthelmintic treatment of neurocysticercosis (NCC) provokes an acute immune response of the host, which in human cases is associated with exacerbation of neurological symptoms. This inflammation can occur at the first da[...]texto impreso
Mahanty, Siddhartha ; Orrego, Miguel A. ; Cangalaya, Carla ; Adrianzen, M. Paz ; Arroyo, Gianfranco ; Calcina, Juan ; Gonzalez, Armando E. ; Garcia, Hector H. ; Guerra-Giraldez, Cristina ; Nash, Theodore E. ; Cysticercosis Working Group in Peru | Public Library of Science | 2019-01-25T16:03:22ZBACKGROUND: Neurocysticercosis (NCC) is an infection of the brain with the larval cyst of the tapeworm, Taenia solium. Cysticidal treatment induces parasite killing resulting in a post inflammatory response and seizures, which generally requires[...]texto impreso
Nicoletti, Alessandra ; Gomez-Puerta, Luis A. ; Arroyo, Gianfranco ; Bustos, Javier ; Gonzalez, Armando E. ; Garcia, Hector H. ; Cysticercosis Working Group in Peru | American Society of Tropical Medicine and Hygiene | 2020-07-14T00:02:36ZHuman exposure to Toxocara spp. is very frequent, and its larvae can cross the blood-brain barrier and invade the central nervous system (CNS), causing neurotoxocariasis. We aimed to establish a neurotoxocariasis animal model in pigs confirmed b[...]
