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Proaño, Alvaro ; Bui, David P. ; López, José W. ; Vu, Nancy M. ; Bravard, Marjory A. ; Lee, Gwenyth O. ; Tracey, Brian H. ; Xu, Ziyue ; Comina, Germán ; Ticona, Eduardo ; Mollura, Daniel J. ; Friedland, Jon S. ; Moore, David A. J. ; Evans, Carlton A. ; Caligiuri, Philip ; Gilman, Robert H. | Elsevier | 2018-11-30T03:10:43ZBACKGROUND: Cough frequency, and its duration, is a biomarker that can be used in low-resource settings without the need of laboratory culture and has been associated with transmission and treatment response. Radiologic characteristics associate[...]texto impreso
Dudley, Matthew Z. ; Sheen, Patricia ; Gilman, Robert H. ; Ticona, Eduardo ; Friedland, Jon S. ; Kirwan, Daniela E. ; Caviedes, Luz ; Rodriguez, Richard ; Cabrera, Lilia Z. ; Coronel, Jorge ; Grandjean, Louis ; Moore, David A. J. ; Evans, Carlton A. ; Huaroto, Luz ; Chavez-Perez, Victor ; Zimic, Mirko | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:45:12ZHospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB. Pyrazinamide (PZA[...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; López, José W. ; Lee, Gwenyth O. ; Bui, David ; Datta, Sumona ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Caviedes, Luz ; Cabrera, Jose L. ; Salas, Antonio ; Ticona, Eduardo ; Vu, Nancy M. ; Kirwan, Daniela E. ; Loader, Maria-Cristina I. ; Friedland, Jon S. ; Moore, David A. J. ; Evans, Carlton A. ; Tracey, Brian H. ; Gilman, Robert H. | Oxford University Press | 2019-01-25T16:59:37ZBackground: Cough is the major determinant of tuberculosis transmission. Despite this, there is a paucity of information regarding characteristics of cough frequency throughout the day and in response to tuberculosis therapy. Here we evaluate th[...]texto impreso
López, José W. ; Loader, Maria-Cristina I. ; Smith, Daniel ; Pastorius, Daniel ; Bravard, Marjory ; Caviedes, Luz ; Romero, Karina M. ; Clark, Taryn ; Checkley, William ; Ticona, Eduardo ; Friedland, Jon S. ; Gilman, Robert H. | American Society of Tropical Medicine and Hygiene | 2018-11-30T03:10:46ZTo reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an eas[...]texto impreso
Martin, Laura ; Coronel, Jorge ; Faulx, Dunia ; Valdez, Melissa ; Metzler, Mutsumi ; Crudder, Chris ; Castillo, Edith ; Caviedes, Luz ; Grandjean, Louis ; Rodriguez, Mitzi ; Friedland, Jon S. ; Gilman, Robert H. ; Moore, David A. J. | Public Library of Science | 2020-06-10T18:12:20ZBACKGROUND: Even though the WHO-endorsed, non-commercial MODS assay offers rapid, reliable TB liquid culture and phenotypic drug susceptibility testing (DST) at lower cost than any other diagnostic, uptake has been patchy. In part this reflects [...]texto impreso
Aldridge, Robert W. ; Nellums, Laura B. ; Bartlett, Sean ; Barr, Anna Louise ; Patel, Parth ; Burns, Rachel ; Hargreaves, Sally ; Miranda, J. Jaime ; Tollman, Stephen ; Friedland, Jon S. ; Abubakar, Ibrahim | Elsevier | 2019-03-05T15:23:28ZBackground: 258 million people reside outside their country of birth; however, to date no global systematic reviews or meta-analyses of mortality data for these international migrants have been done. We aimed to review and synthesise available m[...]texto impreso
Kirwan, Daniela E. ; Ugarte-Gil, Cesar ; Gilman, Robert H. ; Hasan Rizvi, Syed M. ; Cerrillo, Gustavo ; Cok, Jaime ; Ticona, Eduardo ; Cabrera, Jose Luis ; Matos, Eduardo D. ; Evans, Carlton A. ; Moore, David A. J. ; Friedland, Jon S. ; Lymph Node Tuberculosis Working Group | American Society of Tropical Medicine and Hygiene | 2019-01-25T15:18:36ZThe differential diagnosis for lymphadenopathy is wide and clinical presentations overlap, making obtaining an accurate diagnosis challenging. We sought to characterize the clinical and radiological characteristics, histological findings, and di[...]texto impreso
Ugarte-Gil, Cesar ; Elkington, Paul T. ; Gotuzzo, Eduardo ; Friedland, Jon S. ; Moore, David A. J. | American Society of Tropical Medicine and Hygiene | 2020-06-10T18:11:32ZImproved tuberculosis (TB) diagnostics are required. Induced sputum sampling is superior to spontaneous sputum analysis for diagnosis of pulmonary TB. Therefore, we examined the applicability of induced sputum in primary health centers of the P[...]texto impreso
Ugarte-Gil, Cesar ; Elkington, Paul T. ; Gotuzzo, Eduardo ; Friedland, Jon S. ; Moore, David A. J. | American Society of Tropical Medicine and Hygiene | 2019-02-06T14:57:39ZImproved tuberculosis (TB) diagnostics are required. Induced sputum sampling is superior to spontaneous sputum analysis for diagnosis of pulmonary TB. Therefore, we examined the applicability of induced sputum in primary health centers of the P[...]texto impreso
Kirwan, Daniela E. ; Ugarte-Gil, Cesar ; Gilman, Robert H. ; Caviedes, Luz ; Rizvi, Hasan ; Ticona, Eduardo ; Chavez, Gonzalo ; Cabrera, Jose Luis ; Matos, Eduardo D. ; Evans, Carlton A. ; Moore, David A. J. ; Friedland, Jon S. ; Lymph Node TB Working Group | American Society for Microbiology | 2019-02-06T14:52:38ZIn this study, 132 patients with lymphadenopathy were investigated. Fifty-two (39.4%) were diagnosed with tuberculosis (TB). The microscopic observation drug susceptibility (MODS) assay provided rapid (13 days), accurate diagnosis (sensitivity, [...]texto impreso
Ong, Catherine W. M. ; Elkington, Paul T. ; Brilha, Sara ; Ugarte-Gil, Cesar ; Tome-Esteban, Maite T. ; Tezera, Liku B. ; Pabisiak, Przemyslaw J. ; Moores, Rachel C. ; Sathyamoorthy, Tarangini ; Patel, Vimal ; Gilman, Robert H. ; Porter, Joanna C. ; Friedland, Jon S. | Public Library of Science | 2019-02-06T14:53:12ZPulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined. Neutrophils are e[...]texto impreso
Fox, Katharine A. ; Kirwan, Daniela E. ; Whittington, Ashley M. ; Krishnan, Nitya ; Robertson, Brian D. ; Gilman, Robert H. ; López, José W. ; Singh, Shivani ; Porter, Joanna C. ; Friedland, Jon S. | American Thoracic Society | 2018-11-30T22:50:35ZRATIONALE: Platelets may interact with the immune system in tuberculosis (TB) to regulate human inflammatory responses that lead to morbidity and spread of infection. OBJECTIVES: To identify a functional role of platelets in the innate inflammat[...]texto impreso
Proaño, Alvaro ; Bravard, Marjory A. ; Tracey, Brian H. ; López, José W. ; Comina, Germán ; Zimic, Mirko ; Coronel, Jorge ; Lee, Gwenyth O'Neil ; Caviedes, Luz ; Cabrera, Jose Luis ; Salas, Antonio ; Ticona, Eduardo ; Kirwan, Daniela E. ; Friedland, Jon S. ; Evans, Carlton A. ; Moore, David A. ; Gilman, Robert H. | BMJ Publishing Group | 2019-02-06T14:51:43ZINTRODUCTION: Cough is a key symptom of tuberculosis (TB) as well as the main cause of transmission. However, a recent literature review found that cough frequency (number of coughs per hour) in patients with TB has only been studied once, in 19[...]texto impreso
Martin, Laura J. ; Roper, Martha H. ; Grandjean, Louis ; Gilman, Robert H. ; Coronel, Jorge ; Caviedes, Luz ; Friedland, Jon S. ; Moore, David A. J. | BMC | 2019-02-06T14:45:55ZBACKGROUND: Early identification of patients with drug-resistant tuberculosis (DR-TB) increases the likelihood of treatment success and interrupts transmission. Resource-constrained settings use risk profiling to ration the use of drug suscepti[...]texto impreso
Saunders, Matthew J. ; Wingfield, Tom ; Tovar, Marco A. ; Baldwin, Matthew R. ; Datta, Sumona ; Zevallos, Karine ; Montoya, Rosario ; Valencia, Teresa R. ; Friedland, Jon S. ; Moulton, Larry H. ; Gilman, Robert H. ; Evans, Carlton A. | Elsevier | 2019-01-25T15:02:14ZBACKGROUND: Contacts of tuberculosis index cases are at increased risk of developing tuberculosis. Screening, preventive therapy, and surveillance for tuberculosis are underused interventions in contacts, particularly adults. We developed a scor[...]
