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Autor Leon-Velarde, Fabiola |
Documentos disponibles escritos por este autor (26)
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Brito, Julio ; Siques, Patricia ; Arribas, Silvia M. ; Lopez de Pablo, Angel L. ; Gonzalez, M. Carmen ; Naveas, Nelson ; Arriaza, Karem ; Flores, Karen ; Leon-Velarde, Fabiola ; Pulido, Ruth ; Ordenes, Stefany ; Lopez, M. Rosario | Hindawi Publishing Corporation | 2019-02-06T14:52:14ZLong-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and[...]![]()
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Brutsaert, Tom D. ; Kiyamu, Melisa ; Elias Revollendo, Gianpietro ; Isherwood, Jenna L. ; Lee, Frank S. ; Rivera-Ch, Maria ; Leon-Velarde, Fabiola ; Ghosh, Sudipta ; Bigham, Abigail W. | National Academy of Sciences | 2019-12-06T21:02:54ZHighland native Andeans have resided at altitude for millennia. They display high aerobic capacity (VO2max) at altitude, which may be a reflection of genetic adaptation to hypoxia. Previous genomewide (GW) scans for natural selection have nomin[...]![]()
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Siques, Patricia ; Brito, Julio ; Schwedhelm, Edzard ; Pena, Eduardo ; Leon-Velarde, Fabiola ; De La Cruz, Juan Jose ; Boeger, Rainer H. ; Hannemann, Juliane | Frontiers Media | 2019-07-04T16:59:21ZBackground: Prolonged exposure to altitude-associated chronic hypoxia (CH) may cause high-altitude pulmonary hypertension (HAPH). Chronic intermittent hypobaric hypoxia (CIH) occurs in individuals who commute between sea level and high altitude.[...]![]()
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Miranda, J. Jaime ; Bernabé-Ortiz, Antonio ; Diez-Canseco, Francisco ; Malaga, German ; Cárdenas, María K. ; Carrillo-Larco, Rodrigo M. ; Pesantes, M. Amalia ; Araya, Ricardo ; Boggio, Oscar ; Checkley, William ; García, Patricia J. ; Leon-Velarde, Fabiola ; Lescano, Andres G. ; Montori, Victor ; Pan, William ; Rivera-Chira, Maria ; Sacksteder, Katherine ; Smeeth, Liam ; Garcia, Hector H. ; Gilman, Robert H. | Elsevier | 2019-02-06T14:59:06ZThe CRONICAS Centre of Excellence in Chronic Diseases, based at Universidad Peruana Cayetano Heredia, was created in 2009 with support from the U.S. National Heart, Lung, and Blood Institute (NHLBI). The vision of CRONICAS is to build a globally[...]![]()
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Healy, Katherine ; Labrique, Alain B. ; Miranda, J. Jaime ; Gilman, Robert H. ; Danz, David ; Davila-Roman, Victor G. ; Huicho, Luis ; Leon-Velarde, Fabiola ; Checkley, William | Mary Ann Liebert | 2019-02-06T14:45:35ZHealy, Katherine, Alain B. Labrique, J. Jaime Miranda, Robert H. Gilman, David Danz, Victor G. Davila-Roman, Luis Huicho, Fabiola Leon-Velarde, and William Checkley. Dark adaptation at high altitude: an unexpected pupillary response to chronic h[...]![]()
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Villafuerte, Francisco C. ; Macarlupu, Jose Luis ; Anza-Ramirez, Cecilia ; Corrales-Melgar, Daniela ; Vizcardo-Galindo, Gustavo ; Corante, Noemi ; Leon-Velarde, Fabiola | American Physiological Society | 2020-06-10T18:11:31ZExcessive erythrocytosis (EE) is the hallmark of chronic mountain sickness (CMS), a prevalent syndrome in high-altitude Andean populations. Although hypoxemia represents its underlying stimulus, why some individuals develop EE despite having alt[...]![]()
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Kiyamu, Melisa ; Leon-Velarde, Fabiola ; Rivera-Chira, Maria ; Elias, Gianpietro ; Brutsaert, Tom D. | Mary Ann Liebert | 2019-02-06T14:52:35ZKiyamu, Melisa, Fabiola Leon-Velarde, Maria Rivera-Chira, Gianpietro Elias, and Tom D. Brutsaert. Developmental effects determine submaximal arterial oxygen saturation in Peruvian Quechua. High Alt Med Biol 16, 138-146, 2015.--Andean high altitu[...]![]()
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Corante, Noemi ; Anza-Ramirez, Cecilia ; Figueroa-Mujíca, Rómulo ; Macarlupu, Jose Luis ; Vizcardo-Galindo, Gustavo ; Bilo, Grzegorz ; Parati, Gianfranco ; Gamboa, Jorge L. ; Leon-Velarde, Fabiola ; Villafuerte, Francisco C. | Mary Ann Liebert | 2018-11-30T03:10:46ZCorante, Noemí, Cecilia Anza-Ramírez, Rómulo Figueroa-Mujíca, José Luis Macarlupú, Gustavo Vizcardo-Galindo, Grzegorz Bilo, Gianfranco Parati, Jorge L. Gamboa, Fabiola León-Velarde, and Francisco C. Villafuerte. Excessive erythrocytosis and card[...]![]()
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Ghosh, Sudipta ; Kiyamu, Melisa ; Contreras, Paloma ; Leon-Velarde, Fabiola ; Bigham, Abigail ; Brutsaert, Tom D. | Wiley | 2019-12-06T20:57:51ZOBJECTIVES: Andean and Tibetan high-altitude natives exhibit a high concentration of nitric oxide (NO) in the lungs, suggesting that NO plays an adaptive role in offsetting hypobaric hypoxia. We examined the exhaled NO concentration as well as p[...]![]()
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Miele, Catherine H. ; Schwartz, Alan R. ; Gilman, Robert H. ; Pham, Luu ; Wise, Robert A. ; Davila-Roman, Victor G. ; Jun, Jonathan C. ; Polotsky, Vsevolod Y. ; Miranda, J. Jaime ; Leon-Velarde, Fabiola ; Checkley, William | Mary Ann Liebert | 2019-02-06T14:45:56ZMiele, Catherine H., Alan R. Schwartz, Robert H. Gilman, Luu Pham, Robert A. Wise, Victor G. Davila-Roman, Jonathan C. Jun, Vsevolod Y. Polotsky, J. Jaime Miranda, Fabiola Leon-Velarde, and William Checkley. Increased cardiometabolic risk and wo[...]![]()
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Childebayeva, Ainash ; Jones, Tamara R. ; Goodrich, Jaclyn M. ; Leon-Velarde, Fabiola ; Rivera-Chira, Maria ; Kiyamu, Melisa ; Brutsaert, Tom D. ; Dolinoy, Dana C. ; Bigham, Abigail W. | Taylor & Francis | 2019-07-04T17:00:18ZRecent discoveries indicate a genetic basis for high-altitude adaptation among human groups who have resided at high altitude for millennia, including Andeans, Tibetans, and Ethiopians. Yet, genetics alone does not explain the extent of variati[...]![]()
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Lueneburg, Nicole ; Siques, Patricia ; Brito, Julio ; Arriaza, Karem ; Pena, Eduardo ; Klose, Hans ; Leon-Velarde, Fabiola ; Boeger, Rainer H. | Hindawi Publishing Corporation | 2019-02-22T14:54:33ZChronic intermittent hypoxia (CIH) and chronic hypoxia (CH) are associated with high-altitude pulmonary hypertension (HAPH). Asymmetric dimethylarginine (ADMA), a NO synthase (NOS) inhibitor, may contribute to HAPH. This study assessed changes i[...]![]()
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Siques, Patricia ; Brito, Julio ; Flores, Karen ; Ordenes, Stefany ; Arriaza, Karem ; Pena, Eduardo ; Leon-Velarde, Fabiola ; Lopez de Pablo, Angel L. ; Gonzalez, M. C. ; Arribas, Silvia | Frontiers Media | 2018-12-01T00:04:14ZBackground: In chronic hypoxia (CH) and short-term chronic intermittent hypoxia (CIH) exposure, glycemia and insulin levels decrease and insulin sensitivity increases, which can be explained by changes in glucose transport at skeletal muscles in[...]![]()
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Lüneburg, Nicole ; Siques, Patricia ; Brito, Julio ; De La Cruz, Juan Jose ; Leon-Velarde, Fabiola ; Hannemann, Juliane ; Ibanez, Cristian ; Boger, Rainer H. | Mary Ann Liebert | 2019-01-25T15:28:05ZHypoxia-induced dysregulation of pulmonary and cerebral circulation may be related to an impaired nitric oxide (NO) pathway. We investigated the effect of chronic intermittent hypobaric hypoxia (CIH) on metabolites of the NO pathway. We measured[...]![]()
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Brito, Julio ; Siques, Patricia ; Lopez, Rosario ; Romero, Raúl ; Leon-Velarde, Fabiola ; Flores, Karen ; Lueneburg, Nicole ; Hannemann, Juliane ; Boeger, Rainer H. | Frontiers Media | 2018-12-01T00:04:14ZBackground: Living at high altitude or with chronic hypoxia implies functional and morphological changes in the right ventricle and pulmonary vasculature with a 10% prevalence of high-altitude pulmonary hypertension (HAPH). The implications of w[...]![]()
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Siques, Patricia ; Lopez de Pablo, Angel Luis ; Brito, Julio ; Arribas, Silvia M. ; Flores, Karen ; Arriaza, Karem ; Naveas, Nelson ; Gonzalez, M. Carmen ; Hoorntje, Alexander ; Leon-Velarde, Fabiola ; Lopez, M. Rosario | Hindawi Publishing Corporation | 2020-06-10T18:11:33ZWork at high altitude in shifts exposes humans to a new form of chronic intermittent hypoxia, with still unknown health consequences. We have established a rat model resembling this situation, which develops a milder form of right ventricular hy[...]![]()
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Vyas, Kaetan J. ; Danz, David ; Gilman, Robert H. ; Wise, Robert A. ; Leon-Velarde, Fabiola ; Miranda, J. Jaime ; Checkley, William | Mary Ann Liebert | 2019-02-06T14:52:35ZVyas, Kaetan J., David Danz, Robert H. Gilman, Robert A. Wise, Fabiola Leon-Velarde, J. Jaime Miranda, and William Checkley. Noninvasive assessment of excessive erythrocytosis as a screening method for chronic mountain sickness at high altitude.[...]![]()
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Villafuerte, Francisco-C. ; Corante, Noemi ; Anza-Ramirez, Cecilia ; Figueroa-Mujíca, Rómulo ; Vizcardo-Galindo, Gustavo ; Mercado, Andy ; Macarlupu, Jose-Luis ; Leon-Velarde, Fabiola | American Physiological Society | 2019-02-06T14:48:07ZExcessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a highly prevalent syndrome in Andean highlanders. Low pulse O2 saturation (SpO2) during sleep and serum androgens have been suggested to contribute to EE in CMS [...]![]()
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de Ferrari, Aldo ; Miranda, J. Jaime ; Gilman, Robert H. ; Davila-Roman, Victor G. ; Leon-Velarde, Fabiola ; Rivera-Ch, Maria ; Huicho, Luis ; Bernabé-Ortiz, Antonio ; Wise, Robert A. ; Checkley, William | Elsevier | 2020-06-10T18:11:32ZBACKGROUND: Excessive erythrocytosis (EE) is a prevalent condition in populations living at high altitudes (> 2,500 m above sea level). Few large population-based studies have explored the association between EE and multiple subject-specific t[...]![]()
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Glass, Roger I. ; García, Patricia J. ; Belter, Christopher W. ; Livinski, Alicia A. ; Leon-Velarde, Fabiola | Elsevier | 2018-12-03T17:02:46Z![]()
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Hsieh, Matthew-M. ; Callacondo, David ; Rojas-Camayo, Jose ; Quesada-Olarte, Jose ; Wang, Xunde ; Uchida, Naoya ; Maric, Irina ; Remaley, Alan-T. ; Leon-Velarde, Fabiola ; Villafuerte, Francisco-C. ; Tisdale, John-F. | Elsevier | 2019-02-06T14:45:35ZChronic mountain sickness (CMS) results from chronic hypoxia. It is unclear why certain highlanders develop CMS. We hypothesized that modest increases in fetal hemoglobin (HbF) are associated with lower CMS severity. In this cross-sectional stu[...]![]()
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Belter, Christopher W. ; García, Patricia J. ; Livinski, Alicia A. ; Leon-Velarde, Fabiola ; Weymouth, Kristen H. ; Glass, Roger I. | Public Library of Science | 2019-12-06T21:02:56ZOBJECTIVE: In Peru, the past three decades have witnessed impressive growth in biomedical research catalyzed from a single research university and its investigators who secured international partnerships and funding. We conducted a bibliometric[...]![]()
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Belter, Christopher W. ; García, Patricia J. ; Livinski, Alicia A. ; Leon-Velarde, Fabiola ; Weymouth, Kristen H. ; Glass, Roger I. | Public Library of Science | 2019-08-08T15:23:47ZOBJECTIVE: In Peru, the past three decades have witnessed impressive growth in biomedical research catalyzed from a single research university and its investigators who secured international partnerships and funding. We conducted a bibliometric[...]![]()
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Gazal, Steven ; Espinoza, Jose R. ; Austerlitz, Frederic ; Marchant, Dominique ; Macarlupu, Jose Luis ; Rodriguez, Jorge ; Ju-Preciado, Hugo ; Rivera-Chira, Maria ; Hermine, Olivier ; Leon-Velarde, Fabiola ; Villafuerte, Francisco C. ; Richalet, Jean-Paul ; Gouya, Laurent | Frontiers Media | 2019-12-06T20:57:51ZChronic mountain sickness (CMS) is a pathological condition resulting from chronic exposure to high-altitude hypoxia. While its prevalence is high in native Andeans (> 10%), little is known about the genetic architecture of this disease. Here, w[...]![]()
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Miranda, J. Jaime ; Bernabé-Ortiz, Antonio ; Diez-Canseco, Francisco ; Malaga, German ; Cárdenas, María K. ; Carrillo-Larco, Rodrigo M. ; Lazo-Porras, Maria ; Moscoso-Porras, Miguel ; Pesantes, M. Amalia ; Ponce, Vilarmina ; Araya, Ricardo ; Beran, David ; Busse, Peter ; Boggio, Oscar ; Checkley, William ; García, Patricia J. ; Huicho, Luis ; Leon-Velarde, Fabiola ; Lescano, Andres G. ; Mohr, David-C. ; Pan, William ; Peiris, David ; Perel, Pablo ; Rabadan-Diehl, Cristina ; Rivera-Chira, Maria ; Sacksteder, Katherine ; Smeeth, Liam ; Trujillo, Antonio J. ; Wells, Jonathan C. K. ; Yan, Lijing-L. ; Garcia, Hector H. ; Gilman, Robert H. | BMC | 2019-02-06T14:51:22ZHuman capital requires opportunities to develop and capacity to overcome challenges, together with an enabling environment that fosters critical and disruptive innovation. Exploring such features is necessary to establish the foundation of solid[...]![]()
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Espinoza, Jose R. ; Alvarez, Giancarlo ; Leon-Velarde, Fabiola ; Preciado, Hugo F. Ju ; Macarlupu, Jose-Luis ; Rivera-Ch, Maria ; Rodriguez, Jorge ; Favier, Judith ; Gimenez-Roqueplo, Anne-Paule ; Richalet, Jean-Paul | Mary Ann Liebert | 2020-06-10T18:11:38ZA study of chronic mountain sickness (CMS) with a candidate gene--vascular endothelial growth factor A (VEGFA)--was carried out in a Peruvian population living at high altitude in Cerro de Pasco (4380 m). The study was performed by genotyping of[...]