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Título:
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Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies
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Autores:
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Codd, Ellen E. ;
Ng, Hanna H. ;
McFarlane, Claire ;
Riccio, Edward S. ;
Doppalapudi, Rupa ;
Mirsalis, Jon C. ;
Horton, R. John ;
Gonzalez, Armando E. ;
Garcia, H. Hugo ;
Gilman, Robert H.
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Tipo de documento:
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texto impreso
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Editorial:
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Sage publications, 2019-02-06T14:52:38Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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A 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thymus. Female rats had greater oxfendazole exposure and exhibited toxicities at lower doses than did males. Decreased white blood cell levels, a class effect of benzimidazole anthelmintics, returned to normal during the recovery period. The no observed adverse effect level was determined to be >5 but
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En línea:
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http://doi.org/10.1177/1091581815569582
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