|
Título:
|
Automatic Generation of Validated Specific Epitope Sets
|
|
Autores:
|
Carrasco Pro, Sebastian ;
Sidney, John ;
Paul, Sinu ;
Lindestam Arlehamn, Cecilia ;
Weiskopf, Daniela ;
Peters, Bjoern ;
Sette, Alessandro
|
|
Tipo de documento:
|
texto impreso
|
|
Editorial:
|
Hindawi Publishing Corporation, 2019-02-06T14:52:40Z
|
|
Nota general:
|
info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
|
|
Idiomas:
|
Inglés
|
|
Palabras clave:
|
Editados por otras instituciones
,
Artículos
,
Artículos en revistas indizadas
|
|
Resumen:
|
Accurate measurement of B and T cell responses is a valuable tool to study autoimmunity, allergies, immunity to pathogens, and host-pathogen interactions and assist in the design and evaluation of T cell vaccines and immunotherapies. In this context, it is desirable to elucidate a method to select validated reference sets of epitopes to allow detection of T and B cells. However, the ever-growing information contained in the Immune Epitope Database (IEDB) and the differences in quality and subjects studied between epitope assays make this task complicated. In this study, we develop a novel method to automatically select reference epitope sets according to a categorization system employed by the IEDB. From the sets generated, three epitope sets (EBV, mycobacteria and dengue) were experimentally validated by detection of T cell reactivity ex vivo from human donors. Furthermore, a web application that will potentially be implemented in the IEDB was created to allow users the capacity to generate customized epitope sets.
|
|
En línea:
|
http://doi.org/10.1155/2015/763461
|
